{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:51:22Z","timestamp":1753876282266,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Guidelines recommend optimal medical therapy before cardiac resynchronization therapy (CRT) implantation. Herein, we report the potential effect of sodium-glucose cotransporter-2 inhibitors (SGLT2is) in improving the QRS duration and volume reduction in a patient with complete left bundle branch block (CLBBB) and reduced cardiac function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 68-year-old man with a history of ischaemic cardiomyopathy and decreased cardiac function had exacerbation of heart failure (HF) at an outpatient clinic. His QRS duration increased remarkably with a CLBBB of 143\u2005ms on an electrocardiogram, and left ventricular desynchrony was assessed by echocardiography, suggesting an indication of CRT implantation. Administration of an SGLT2i and multimodal treatment for HF stabilized his HF condition and improved the QRS duration and volume reduction thereafter. The CLBBB recovered to incomplete LBBB with a QRS duration of 112\u2005ms on electrocardiography after 6 months. The patient has been stably followed up with continuous medications, including SGLT2i, without requiring CRT implantation or worsening of HF for 12 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This case presents a unique scenario wherein electrical and mechanical reverse remodelling occurred in a patient with systolic HF and CLBBB, highlighting the potential benefits of SGLT2i in HF management. It may be important to carefully consider CRT indications when seeking other options to treat HF conditions and recognize an unusual phenomenon of reverse LBBB in clinical cases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae512","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T17:17:45Z","timestamp":1726334265000},"source":"Crossref","is-referenced-by-count":1,"title":["Reversible complete left bundle branch block and a wide QRS complex following administration of sodium-glucose cotransporter-2 inhibitor and volume reduction in a patient with systolic heart failure: a case report"],"prefix":"10.1093","volume":"8","author":[{"given":"Masaki","family":"Takenaka","sequence":"first","affiliation":[{"name":"Department of Cardiology, Takabari Heart Clinic , 1-1525 Takabari, Meito-ku, Nagoya, Aichi 465-0061 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0658-5498","authenticated-orcid":false,"given":"Satoshi","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nagoya University Graduate School of Medicine , 65 Tsurumai, Showa, Nagoya, Aichi 466-8550 ,","place":["Japan"]},{"name":"Department of Advanced Cardiovascular Therapeutics, Nagoya University Graduate School of Medicine , 65 Tsurumai, Showa, Nagoya, Aichi 466-8550 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital , 2-9 Myoken-cho, Showa, Nagoya, Aichi 466-8650 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuya","family":"Inden","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nagoya University Graduate School of Medicine , 65 Tsurumai, Showa, Nagoya, Aichi 466-8550 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoaki","family":"Murohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nagoya University Graduate School of Medicine , 65 Tsurumai, Showa, Nagoya, Aichi 466-8550 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"key":"2024092813161587500_ytae512-B1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yjmcc.2021.05.012","article-title":"Molecular remodeling of Cx43, but not structural remodeling, promotes arrhythmias in an arrhythmogenic canine model of nonischemic heart failure","volume":"158","author":"Yan","year":"2021","journal-title":"J Mol Cell Cardiol"},{"key":"2024092813161587500_ytae512-B2","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/eurheartj\/ehab364","article-title":"2021 ESC guidelines on cardiac pacing and cardiac resynchronization therapy","volume":"42","author":"Glikson","year":"2021","journal-title":"Eur Heart J"},{"key":"2024092813161587500_ytae512-B3","first-page":"164","article-title":"Delayed spontaneous reversibility of left bundle branch block in non-ischemic cardiomyopathy: a case report","volume":"17","author":"Carvalho","year":"2020","journal-title":"J Geriatr Cardiol"},{"key":"2024092813161587500_ytae512-B4","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.jelectrocard.2016.07.008","article-title":"Spontaneous resolution of left bundle branch block and biventricular stimulation lead to reverse remodeling in dyssynchronopathy","volume":"49","author":"Kloosterman","year":"2016","journal-title":"J Electrocardiol"},{"key":"2024092813161587500_ytae512-B5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.eupc.2004.12.009","article-title":"The impact of changing oedematous states on the QRS duration: implications for cardiac resynchronization therapy and implantable cardioverter\/defibrillator implantation","volume":"7","author":"Madias","year":"2005","journal-title":"Europace"},{"key":"2024092813161587500_ytae512-B6","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.81.4.1161","article-title":"Ventricular remodeling after myocardial infarction. 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