{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:51:30Z","timestamp":1753876290099,"version":"3.41.2"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Endocarditis is an infectious disease, with an incidence of \u223c15 cases per 100 000 people, affecting the tricuspid valve in 10% of cases. Infective endocarditis with negative blood cultures (BCNIE) accounts for more than 20% of cases of infective endocarditis. Perivalvular extension of the infection represents the most detrimental complications of BCNIE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 25-year-old South Asian male was admitted due to fever for 15 days and new onset chest pain. The blood tests showed an increase in inflammatory indices. A chest X-ray showed enlargement of the cardiac shadow. On cardiac examination, a holosystolic murmur at the left sternal edge border was heard. The transthoracic echocardiogram showed a filamentous formation on the tricuspid valve and communication between the aorta and right atrium with left\u2013right shunt. A transoesophageal echocardiogram (TEE) was performed to confirm the diagnosis of IE. Three sets of blood cultures were performed, with negative results, empirical therapy was managed and a decision for TEE-guided cardiac surgery was made.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Fistula is a rare complication of IE representing the most insidious consequence of uncontrolled infection like BCNIE, a condition that has restricted the therapeutic possibilities to empirical therapy only and to early surgery. The TEE was instrumental in diagnosing right-sided infective endocarditis and allowing us to focus on the perivalvular spread of the infection in our case.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae570","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T17:12:55Z","timestamp":1729617175000},"source":"Crossref","is-referenced-by-count":0,"title":["A rare complication of blood culture-negative infective endocarditis on tricuspid valve: case report"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2360-8865","authenticated-orcid":false,"given":"Giovanni","family":"Bellina","sequence":"first","affiliation":[{"name":"Azienda Ospedaliera Universitaria Policlinico \u2018G. Rodolico-San Marco\u2019 , Via S. Sofia 78, 95100 Catania ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Scandura","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria Policlinico \u2018G. Rodolico-San Marco\u2019 , Via S. Sofia 78, 95100 Catania ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5340-2589","authenticated-orcid":false,"given":"Salvatore","family":"Lentini","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria Policlinico \u2018G. Rodolico-San Marco\u2019 , Via S. Sofia 78, 95100 Catania ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-7723","authenticated-orcid":false,"given":"Davide","family":"Capodanno","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria Policlinico \u2018G. Rodolico-San Marco\u2019 , Via S. Sofia 78, 95100 Catania ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4940-9742","authenticated-orcid":false,"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria Policlinico \u2018G. Rodolico-San Marco\u2019 , Via S. Sofia 78, 95100 Catania ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"2024112719261813700_ytae570-B1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/CRD.0000000000000095","article-title":"Right-sided infective endocarditis and pulmonary infiltrates: an update","volume":"24","author":"Chahoud","year":"2016","journal-title":"Cardiol Rev"},{"key":"2024112719261813700_ytae570-B2","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ejim.2013.01.010","article-title":"Native valve right sided infective endocarditis","volume":"24","author":"Akinosoglou","year":"2013","journal-title":"Eur J Intern Med"},{"key":"2024112719261813700_ytae570-B3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2147\/IJGM.S393329","article-title":"Blood culture negative endocarditis: a review of laboratory diagnostic approaches","volume":"16","author":"Lin","year":"2023","journal-title":"Int J Gen Med"},{"key":"2024112719261813700_ytae570-B4","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad193","article-title":"2023 ESC guidelines for the management of endocarditis","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur Heart J"},{"key":"2024112719261813700_ytae570-B5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/eurheartj\/ehi076","article-title":"Aorto-cavitary fistulae in infective endocarditis: understanding a rare complication through collaboration","volume":"26","author":"Jenkins","year":"2005","journal-title":"Eur Heart J"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytae570\/59968402\/ytae570.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/8\/11\/ytae570\/60665872\/ytae570.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/8\/11\/ytae570\/60665872\/ytae570.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T19:27:04Z","timestamp":1732735624000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytae570\/7831348"}},"subtitle":[],"editor":[{"given":"Amir","family":"Khalifa","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Saadia","family":"Aslam","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Melissa Yen","family":"Moey","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Karelas","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":5,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytae570","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,10,22]]},"article-number":"ytae570"}}