{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:56:21Z","timestamp":1793314581783,"version":"4.5.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The combined therapy with venoarterial extracorporeal membrane oxygenation and Impella (ECPella) has been shown to improve survival in acute cardiogenic shock (CS) in adult patient. Only three paediatric cases have been reported in a multicentre study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We present our case, the first described to our knowledge in the UK, of a 15-year-old adolescent of Afro-Caribbean descent, weight 75\u2005kg, who received extracorporeal cardiopulmonary resuscitation (E-CPR) and ECPella implantation. The patient suffered a sudden cardiac arrest at home; his mother called for an ambulance that arrived within 10\u2005min and commenced life support with a LUCAS device. He received three doses of adrenaline and three desynchronized shocks for an underlying rhythm of ventricular fibrillation (VF) after which return of spontaneous circulation was achieved. He was then transferred to his local hospital where he had another VF arrest with successful cardioversion and was then transferred to our institution where on arrival he had another VF arrest and received E-CPR and ECPella implantation under the institutional adult shock programme within 3\u2005h of in-hospital cardiac arrest. Following weaning from ECPella, the patient underwent cardiac and brain magnetic resonance imaging and serial echocardiograms with complete recovery of ventricular function. After implantation of cardiac defibrillator, he was discharged home without neurological sequelae. He remains asymptomatic from a cardiac perspective, with a normal cardiac examination and with no neurological sequelae at 2-year follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This is the first case description of ECPella use in a child in the UK and highlighted the importance of timely institution of E-CPR on survival benefit in fatal CS. The outcome success of post-resuscitation ECPella strategy in this adolescent was through collaborative interprofessional engagement of multiple supra-specialists within acute cardiology and critical care across paediatric and adult services and alignment with the institutional adult shock programme.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae581","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T19:01:14Z","timestamp":1731006074000},"source":"Crossref","is-referenced-by-count":2,"title":["Survival after extracorporeal cardiopulmonary resuscitation for adolescent arrhythmogenic arrest: ECPella (extracorporeal membrane oxygenation with Impella\u00ae)\u2014a case report"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6781-1427","authenticated-orcid":false,"given":"Anouska","family":"Lerner","sequence":"first","affiliation":[{"name":"Department of Paediatric Cardiology, Royal Brompton Hospital , Sydney Street, London SW3 6NP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-6134","authenticated-orcid":false,"given":"Ajay","family":"Desai","sequence":"additional","affiliation":[{"name":"PICU, Level 4, Royal Brompton Hospital, Sydney Street , London SW3 6NP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Trimlett","sequence":"additional","affiliation":[{"name":"AICU, Level 5, Royal Brompton Hospital, Sydney Street , London SW3 6NP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3089-016X","authenticated-orcid":false,"given":"Janice","family":"Till","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Royal Brompton Hospital , Sydney Street, London SW3 6NP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4161-1065","authenticated-orcid":false,"given":"Amy","family":"Chan-Dominy","sequence":"additional","affiliation":[{"name":"PICU, Level 4, Royal Brompton Hospital, Sydney Street , London SW3 6NP ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"2024122016494865700_ytae581-B1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/CIRCULATIONAHA.119.042173","article-title":"Improved survival with extracorporeal cardiopulmonary resuscitation despite progressive metabolic derangement associated with prolonged resuscitation","volume":"141","author":"Bartos","year":"2020","journal-title":"Circulation"},{"key":"2024122016494865700_ytae581-B2","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/S0140-6736(20)32338-2","article-title":"Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial","volume":"396","author":"Yannopoulos","year":"2020","journal-title":"Lancet"},{"key":"2024122016494865700_ytae581-B3","doi-asserted-by":"crossref","first-page":"101988","DOI":"10.1016\/j.eclinm.2023.101988","article-title":"Intraarrest transport, extracorporeal cardiopulmonary resuscitation, and early invasive management in refractory out-of-hospital cardiac arrest: an individual patient data pooled analysis of two randomised trials","volume":"59","author":"Belohlavek","year":"2023","journal-title":"EClinicalMedicine"},{"key":"2024122016494865700_ytae581-B4","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1097\/CCM.0000000000001484","article-title":"Incidence and outcomes of cardiopulmonary resuscitation in PICUs","volume":"44","author":"Berg","year":"2016","journal-title":"Crit Care Med"},{"key":"2024122016494865700_ytae581-B5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/PCC.0000000000003368","article-title":"Survival with favorable neurologic outcome and quality of cardiopulmonary resuscitation following in-hospital cardiac arrest in children with cardiac disease compared with noncardiac disease","volume":"25","author":"Federman","year":"2024","journal-title":"Pediatr Crit Care Med"},{"key":"2024122016494865700_ytae581-B6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1164\/rccm.201710-2130CP","article-title":"The extracorporeal life support organization Maastricht treaty for nomenclature in extracorporeal life support. 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