{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:20:27Z","timestamp":1793146827853,"version":"4.5.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hypertrophic cardiomyopathy (HCM) is an inherited condition characterized by left ventricular (LV) hypertrophy unexplained by increased afterload, often with concomitant outflow tract obstruction. Verapamil is commonly used to treat symptomatic patients. However, its potential for adverse effects should be recognized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>This report provides a case of cardiogenic shock in HCM, where a patient presented with chief complaint of fatigue and shortness of breath with an acute decline in LV systolic function on echocardiogram. His symptoms were attributed to verapamil toxicity following a recent increase in dosage. He achieved rapid symptom relief after holding his home medications, in addition to conservative management.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This case report aims to elucidate the potential for multiple adverse effects involved with verapamil use in patients with obstructive HCM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae596","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T15:15:02Z","timestamp":1732115702000},"source":"Crossref","is-referenced-by-count":3,"title":["A case report of verapamil toxicity leading to haemodynamic compromise in obstructive hypertrophic cardiomyopathy"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2297-4618","authenticated-orcid":false,"given":"Jonathan W","family":"Gau","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of California, Irvine , 101 City Dr S, Orange, CA 92868, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Rader","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute , 127 S San Vicente Blvd Pavilion Suite A3600, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behram","family":"Mody","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, University of California, Irvine, 333 City Blvd W, Orange, CA 92868, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy Y","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, University of California, Irvine, 333 City Blvd W, Orange, CA 92868, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"2024122016503435900_ytae596-B1","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1016\/j.jacc.2020.08.045","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy","volume":"76","author":"Ommen","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2024122016503435900_ytae596-B2","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1161\/CIRCULATIONAHA.106.644682","article-title":"Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction","volume":"114","author":"Maron","year":"2006","journal-title":"Circulation"},{"key":"2024122016503435900_ytae596-B3","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1161\/01.CIR.92.7.1680","article-title":"Hypertrophic cardiomyopathy","volume":"92","author":"Wigle","year":"1995","journal-title":"Circulation"},{"key":"2024122016503435900_ytae596-B4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0002-8703(82)90192-2","article-title":"Prolongation of verapamil elimination kinetics during chronic oral administration","volume":"104","author":"Schwartz","year":"1982","journal-title":"Am Heart J"},{"key":"2024122016503435900_ytae596-B5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0002-9343(85)90169-X","article-title":"Use of calcium channel blockers in hypertrophic cardiomyopathy","volume":"78","author":"Lorell","year":"1985","journal-title":"Am J Med"},{"key":"2024122016503435900_ytae596-B6","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1161\/01.CIR.60.6.1201","article-title":"Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy. 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