{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:49:38Z","timestamp":1753876178135,"version":"3.41.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Tricuspid regurgitation (TR) is a common valvular complication following heart transplantation. Transcatheter tricuspid valve replacement exists as a novel treatment option. However, as with any procedure, important complications can occur and warrant discussion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 46-year-old woman, status post-orthotopic heart transplant (HT), developed symptomatic severe TR. She underwent transcatheter tricuspid valve replacement (TTVR; EVOQUE system, Edwards Lifesciences) and was subsequently presented to the hospital following a syncopal event. She was found to be in cardiogenic shock with complete heart block on an electrocardiogram that degenerated into sudden cardiac death. Although the valve was well-seated, autopsy revealed areas of focal necrosis where the bioprosthetic valve was seated in the region of the atrioventricular node and His bundle.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This is the first case report of a complication of transcatheter tricuspid valve replacement in a heart transplant patient resulting in complete heart block and sudden cardiac death. While TTVR may be a good treatment option for select patients in this high-risk group, conduction system damage is a potential complication given the anatomy of the region and requires very close monitoring. This case further highlights the unique physiology of HT patients and illustrates the fact that bradyarrhythmias are often poorly tolerated and potentially lethal.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae599","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T11:50:48Z","timestamp":1731498648000},"source":"Crossref","is-referenced-by-count":1,"title":["Complete heart block and subsequent sudden cardiac death following transcatheter tricuspid valve replacement in a heart transplant patient: a case report"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9438-4652","authenticated-orcid":false,"given":"Andy","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Medicine, Western University , London, ON N6A 5W9 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Davey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Western University , London, ON N6A 5W9 ,","place":["Canada"]},{"name":"Division of Cardiology, Department of Medicine, Western University , 339 Windermere Rd, London, ON N6A 5A5 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J","family":"Tweedie","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Western University , London, ON N6A 5C1 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9236-196X","authenticated-orcid":false,"given":"Stuart J","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, Western University , London, ON N6A 5W9 ,","place":["Canada"]},{"name":"Division of Cardiology, Department of Medicine, Western University , 339 Windermere Rd, London, ON N6A 5A5 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"2024122016494119700_ytae599-B1","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1016\/j.transproceed.2022.09.009","article-title":"Prevalence of tricuspid regurgitation after orthotopic heart transplantation and its evolution in the follow-up period: a long-term study","volume":"54","author":"Lopez-Vilella","year":"2022","journal-title":"Transplant Proc"},{"key":"2024122016494119700_ytae599-B2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.healun.2007.12.011","article-title":"Tricuspid regurgitation after cardiac transplantation: an old problem revisited","volume":"27","author":"Wong","year":"2008","journal-title":"J Heart Lung Transplant"},{"key":"2024122016494119700_ytae599-B3","doi-asserted-by":"crossref","first-page":"10197","DOI":"10.3389\/ti.2022.10197","article-title":"Epidemiological study of tricuspid regurgitation after cardiac transplantation. Does it influence survival?","volume":"35","author":"L\u00f3pez-Vilella","year":"2022","journal-title":"Transpl Int"},{"key":"2024122016494119700_ytae599-B4","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1053-2498(01)00258-3","article-title":"Severe tricuspid regurgitation after heart transplantation","volume":"20","author":"Chan","year":"2001","journal-title":"J Heart Lung Transplant"},{"key":"2024122016494119700_ytae599-B5","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S1053-2498(02)00433-3","article-title":"Clinical significance of tricuspid valve dysfunction after orthotopic heart transplantation","volume":"21","author":"Aziz","year":"2002","journal-title":"J Heart Lung Transplant"},{"key":"2024122016494119700_ytae599-B6","first-page":"662","article-title":"Understanding tricuspid regurgitation post cardiac transplantation; why \u201canatomical\u201d and \u201cfunctional\u201d won\u2019t cut it","volume":"108","author":"Bart","year":"2024","journal-title":"Transplantation"},{"key":"2024122016494119700_ytae599-B7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1159\/000507179","article-title":"In-hospital outcomes and trends of tricuspid valve surgery in heart transplant patients","volume":"5","author":"Mohammed","year":"2020","journal-title":"Biomed Hub"},{"key":"2024122016494119700_ytae599-B8","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tcm.2023.10.003","article-title":"Transcatheter valvular interventions after heart transplantation: a systematic review","volume":"34","author":"Cuko","year":"2024","journal-title":"Trends Cardiovasc Med"},{"key":"2024122016494119700_ytae599-B9","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1093\/eurheartj\/ehad667","article-title":"Transfemoral tricuspid valve replacement and one-year outcomes: the TRISCEND study","volume":"44","author":"Kodali","year":"2023","journal-title":"Euro Heart J"},{"key":"2024122016494119700_ytae599-B10","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jacc.2020.12.062","article-title":"Ambulatory electrocardiogram monitoring in patients undergoing transcatheter aortic valve replacement: JACC state-of-the-art review","volume":"77","author":"Muntan\u00e9-Carol","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2024122016494119700_ytae599-B11","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cjco.2020.04.006","article-title":"Remote ambulatory cardiac monitoring before and after transcatheter aortic valve replacement","volume":"2","author":"Winter","year":"2020","journal-title":"CJC Open"},{"key":"2024122016494119700_ytae599-B12","doi-asserted-by":"crossref","first-page":"e004070","DOI":"10.1161\/JAHA.116.004070","article-title":"Early denervation and later reinnervation of the heart following cardiac transplantation: a review","volume":"5","author":"Awad","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"2024122016494119700_ytae599-B13","first-page":"164","article-title":"Function of the transplanted heart: unique physiology and therapeutic implications","volume":"314","author":"Cotts","year":"1997","journal-title":"Am J Med Sci"},{"key":"2024122016494119700_ytae599-B14","doi-asserted-by":"crossref","first-page":"e14081","DOI":"10.1111\/ctr.14081","article-title":"Beta-blocker therapy in heart transplant recipients: a review","volume":"34","author":"Masarone","year":"2020","journal-title":"Clin Transplant"},{"key":"2024122016494119700_ytae599-B15","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/eurheartj\/ehab364","article-title":"2021 ESC guidelines on cardiac pacing and cardiac resynchronization therapy","volume":"42","author":"Glikson","year":"2021","journal-title":"Euro Heart J"}],"container-title":["European Heart Journal - 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