{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:51:35Z","timestamp":1753876295628,"version":"3.41.2"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Initially conceptualized as a bridge to heart transplantation, the left ventricular assist device (LVAD) has become an important option for improving survival in patients with severe heart failure and poor prognosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We report the case of a patient suffering from severe chronic heart failure, complicated by ST-elevation myocardial infarction due to left main coronary artery stenosis (NYHA IV, INTERMACS profile 1). Despite support with veno-arterial extracorporeal membrane oxygenation, inotropes, and catecholamine therapy, the patient\u2019s cardiac function did not recover sufficiently. Consequently, the decision was made to proceed with LVAD implantation as destination therapy. The initial LVAD implantation was uneventful, and the patient received anticoagulant therapy according to standard operating procedure. However, pump thrombosis occurred on the first post-operative day, necessitating an LVAD exchange. Following an extended stay in the cardiac surgery intensive care unit, the patient was eventually discharged. Approximately 15 months later, the patient developed a driveline infection, involving most of the intrapericardial components of the LVAD. A second LVAD exchange was required, and the patient received a third LVAD. To mitigate the risk of recurrent infection, suppressive antibiotic therapy with ampicillin\/sulbactam was initiated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This is the first reported case of a patient surviving three LVAD implantations and highlights an instance of off-label use of lifelong antibiotic therapy following a driveline infection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae618","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T10:57:25Z","timestamp":1731754645000},"source":"Crossref","is-referenced-by-count":0,"title":["Survival of a patient following initial left ventricular assist device implantation and two successive left ventricular assist device exchanges: case report"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5673-8424","authenticated-orcid":false,"given":"Luca","family":"Scarsella","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Center for Clinical and Translational Research, Helios University Hospital Wuppertal , Heusnerstra\u00dfe 40, 42283 Wuppertal ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Bentley","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Center for Clinical and Translational Research, Helios University Hospital Wuppertal , Heusnerstra\u00dfe 40, 42283 Wuppertal ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Ishaq","family":"Amer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Helios University Hospital Wuppertal , Arrenberger Str.20, 42117 Wuppertal ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge C","family":"Thal","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Center for Clinical and Translational Research, Helios University Hospital Wuppertal , Heusnerstra\u00dfe 40, 42283 Wuppertal ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"2024122016534271600_ytae618-B1","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3390\/jcm11072022","article-title":"The history of durable left ventricular assist devices and comparison of outcomes: HeartWare, HeartMate II, HeartMate 3, and the future of mechanical circulatory support","volume":"11","author":"Berardi","year":"2022","journal-title":"J Clin Med"},{"key":"2024122016534271600_ytae618-B2","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa012175","article-title":"Long-term use of a left ventricular assist device for end-stage heart failure","volume":"345","author":"Rose","year":"2001","journal-title":"N Engl J Med"},{"key":"2024122016534271600_ytae618-B3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1527-5299.2005.04540.x","article-title":"Long-term destination therapy with the HeartMate XVE left ventricular assist device: improved outcomes since the REMATCH study","volume":"11","author":"Long","year":"2005","journal-title":"Congest Heart Fail"},{"key":"2024122016534271600_ytae618-B4","doi-asserted-by":"crossref","first-page":"S1692","DOI":"10.21037\/jtd.2018.01.26","article-title":"Less invasive HeartMate 3 left ventricular assist device implantation","volume":"10","author":"Schmitto","year":"2018","journal-title":"J Thorac Dis"},{"key":"2024122016534271600_ytae618-B5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/aor.13387","article-title":"Bilateral mini-thoracotomy approach for minimally invasive implantation of HeartMate 3","volume":"43","author":"Carrozzini","year":"2019","journal-title":"Artif Organs"},{"key":"2024122016534271600_ytae618-B6","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.jacc.2022.01.017","article-title":"Trends and outcomes of left ventricular assist device therapy: JACC focus seminar","volume":"79","author":"Varshney","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2024122016534271600_ytae618-B7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.athoracsur.2018.11.011","article-title":"The society of thoracic surgeons Intermacs database annual report: evolving indications, outcomes, and scientific partnerships","volume":"107","author":"Kormos","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"2024122016534271600_ytae618-B8","first-page":"1065","article-title":"Left ventricular assist device as a destination therapy: current situation and the importance of patient selection","volume":"13","author":"Melendo-Viu","year":"2023","journal-title":"Life (Basel)"},{"author":"HeartMate III","key":"2024122016534271600_ytae618-B9"},{"key":"2024122016534271600_ytae618-B10","first-page":"e238154","article-title":"Pearls in anticoagulation management for patients with left ventricular assist devices","volume":"50","author":"Yin","year":"2023","journal-title":"Tex Heart Inst J"},{"key":"2024122016534271600_ytae618-B11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1313385","article-title":"Unexpected abrupt increase in left ventricular assist device thrombosis","volume":"370","author":"Starling","year":"2014","journal-title":"N Engl J Med"},{"key":"2024122016534271600_ytae618-B12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.12659\/MSMBR.894840","article-title":"Continuous-flow left ventricular assist device thrombosis: a danger foreseen is a danger avoided","volume":"21","author":"Fatullayev","year":"2015","journal-title":"Med Sci Monit Basic Res"},{"key":"2024122016534271600_ytae618-B13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3390\/jcm10030453","article-title":"Ventricular assist device-specific infections","volume":"10","author":"Qu","year":"2021","journal-title":"J Clin Med"},{"key":"2024122016534271600_ytae618-B14","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1161\/01.CIR.95.4.814","article-title":"Left ventricular assist device infection is associated with increased mortality but is not a contraindication to transplantation","volume":"95","author":"Herrmann","year":"1997","journal-title":"Circulation"},{"key":"2024122016534271600_ytae618-B15","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1093\/eurheartj\/ehaa639","article-title":"Two-year outcome after implantation of a full magnetically levitated left ventricular assist device: results from the ELEVATE Registry","volume":"41","author":"Zimpfer","year":"2020","journal-title":"Eur Heart J"},{"key":"2024122016534271600_ytae618-B16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/QCO.0000000000000999","article-title":"Left ventricular assist device-associated driveline infections as a specific form of complicated skin and soft tissue infection\/acute bacterial skin and skin structure infection\u2014issues and therapeutic options","volume":"37","author":"Eckmann","year":"2024","journal-title":"Curr Opin Infect Dis"},{"key":"2024122016534271600_ytae618-B17","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.12659\/AJCR.916404","article-title":"Long-term left ventricular assist device (LVAD): a rare case of 10 years\u2019 support and follow-up","volume":"20","author":"Zhigalov","year":"2019","journal-title":"Am J Case Rep"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytae618\/60693183\/ytae618.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/8\/12\/ytae618\/61086017\/ytae618.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/8\/12\/ytae618\/61086017\/ytae618.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T16:54:08Z","timestamp":1734713648000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytae618\/7901697"}},"subtitle":[],"editor":[{"given":"Edoardo","family":"Zancanaro","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Jamol","family":"Uzokov","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,11,16]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,11,28]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytae618","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2024,12]]},"published":{"date-parts":[[2024,11,16]]},"article-number":"ytae618"}}