{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:49:42Z","timestamp":1753876182054,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Haemochromatosis is a pathological condition characterized by the accumulation of iron in parenchymal organs, leading to toxic damage and dysfunction. Cardiac haemochromatosis represents one of the rare causes of severe heart failure (HF) that can be potentially prevented with targeted treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case Summary<\/jats:title>\n                  <jats:p>We present the case of a 41-year-old female who was hospitalized for decompensated HF. Echocardiography revealed severe systolic dysfunction with a phenotype of dilated cardiomyopathy, accompanied by secondary moderate mitral regurgitation and severe tricuspid regurgitation (TR). To differentiate potential causes of HF, coronary angiography, cardiac magnetic resonance imaging (MRI), and endomyocardial biopsy were performed. Based on clinical findings, laboratory results, cardiac MRI, and endomyocardial biopsy data, a diagnosis of haemochromatosis was confirmed, and mutations in the TFR2 gene, responsible for haemochromatosis Type 3, were identified. The patient was treated in accordance with the latest European Society of Cardiology HF guidelines, and specific treatment for haemochromatosis, including therapeutic phlebotomy and iron chelation therapy, was initiated, resulting in a significant positive outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Investigating the aetiology of HF is essential, as even rare causes can be identified, and specific treatments are available that significantly improve prognosis and survival.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae637","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T12:49:46Z","timestamp":1732884586000},"source":"Crossref","is-referenced-by-count":2,"title":["Heart failure of very rare aetiology\u2014haemochromatosis Type 3: a case report"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8628-913X","authenticated-orcid":false,"given":"Aist\u0117","family":"Montvilait\u0117-Laurinavi\u010dien\u0117","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Lithuanian University of Health Sciences , A. Mickevi\u010diaus Str. 9, 44307 Kaunas ,","place":["Lithuania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-2265","authenticated-orcid":false,"given":"R\u016bta","family":"Dirsien\u0117","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lithuanian University of Health Sciences , A. Mickevi\u010diaus Str. 9, 44307 Kaunas ,","place":["Lithuania"]},{"name":"Department of Cardiology, Lithuanian University of Health Sciences , Eiveni\u0173 Str. 2, 50161 Kaunas ,","place":["Lithuania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gintar\u0117","family":"Neverauskait\u0117-Piliponien\u0117","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lithuanian University of Health Sciences , A. Mickevi\u010diaus Str. 9, 44307 Kaunas ,","place":["Lithuania"]},{"name":"Department of Cardiology, Lithuanian University of Health Sciences , Eiveni\u0173 Str. 2, 50161 Kaunas ,","place":["Lithuania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4695-485X","authenticated-orcid":false,"given":"Audra","family":"Bani\u0161auskait\u0117","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lithuanian University of Health Sciences , A. Mickevi\u010diaus Str. 9, 44307 Kaunas ,","place":["Lithuania"]},{"name":"Department of Radiology, Lithuanian University of Health Sciences , Eiveni\u0173 Str. 2, 50161 Kaunas ,","place":["Lithuania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-0223","authenticated-orcid":false,"given":"Marius","family":"\u0160ukys","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lithuanian University of Health Sciences , A. Mickevi\u010diaus Str. 9, 44307 Kaunas ,","place":["Lithuania"]},{"name":"Department of Genetics and Laboratory Medicine, Lithuanian University of Health Sciences , Eiveni\u0173 Str. 2, 50161 Kaunas ,","place":["Lithuania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gintar\u0117","family":"\u0160akalyt\u0117","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lithuanian University of Health Sciences , A. Mickevi\u010diaus Str. 9, 44307 Kaunas ,","place":["Lithuania"]},{"name":"Department of Cardiology, Lithuanian University of Health Sciences , Eiveni\u0173 Str. 2, 50161 Kaunas ,","place":["Lithuania"]},{"name":"Institute of Cardiology, Lithuanian University of Health Sciences , Sukil\u0117li\u0173 Av. 15, 50161 Kaunas ,","place":["Lithuania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8332-788X","authenticated-orcid":false,"given":"Egl\u0117","family":"Ereminien\u0117","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lithuanian University of Health Sciences , A. Mickevi\u010diaus Str. 9, 44307 Kaunas ,","place":["Lithuania"]},{"name":"Department of Cardiology, Lithuanian University of Health Sciences , Eiveni\u0173 Str. 2, 50161 Kaunas ,","place":["Lithuania"]},{"name":"Institute of Cardiology, Lithuanian University of Health Sciences , Sukil\u0117li\u0173 Av. 15, 50161 Kaunas ,","place":["Lithuania"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"2024121612173526000_ytae637-B1","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC Guidelines for the management of cardiomyopathies: developed by the task force on the management of cardiomyopathies of the European Society of Cardiology (ESC)","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"key":"2024121612173526000_ytae637-B2","doi-asserted-by":"crossref","first-page":"7722","DOI":"10.3390\/ijms22147722","article-title":"Cardiomyopathies: an overview","volume":"22","author":"Ciarambino","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024121612173526000_ytae637-B3","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jacc.2010.03.083","article-title":"Iron overload cardiomyopathy: better understanding of an increasing disorder","volume":"56","author":"Gujja","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2024121612173526000_ytae637-B4","doi-asserted-by":"crossref","first-page":"560","DOI":"10.5114\/aoms.2017.68729","article-title":"Management of cardiac hemochromatosis","volume":"14","author":"Aronow","year":"2018","journal-title":"Arch Med Sci"},{"key":"2024121612173526000_ytae637-B5"},{"key":"2024121612173526000_ytae637-B6","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"2024121612173526000_ytae637-B7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11886-018-1030-7","article-title":"Genetics of dilated cardiomyopathy: clinical implications","volume":"20","author":"Paldino","year":"2018","journal-title":"Curr Cardiol Rep"},{"key":"2024121612173526000_ytae637-B8","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/joim.12944","article-title":"Dilated cardiomyopathy: from epidemiologic to genetic phenotypes: a translational review of current literature","volume":"286","author":"Reichart","year":"2019","journal-title":"J Intern Med"},{"key":"2024121612173526000_ytae637-B9","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/jmri.27023","article-title":"Cardiac T2* mapping: techniques and clinical applications","volume":"52","author":"Triadyaksa","year":"2020","journal-title":"J Magn Reson Imaging"},{"key":"2024121612173526000_ytae637-B10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1517\/14740330903535845","article-title":"Safety issues of iron chelation therapy in patients with normal range iron stores including thalassemia, neurodegenerative, renal and infectious diseases","volume":"9","author":"Kontoghiorghes","year":"2010","journal-title":"Expert Opin Drug Saf"}],"container-title":["European Heart Journal - 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