{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:30:46Z","timestamp":1782286246960,"version":"3.54.5"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Transthyretin cardiac amyloidosis is associated with various arrhythmias, including atrioventricular block. Despite this correlation, established treatments for transthyretin cardiac amyloidosis-associated arrhythmias are lacking. Left bundle branch area pacing is a promising physiological pacing technique.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>This case series describes three instances of successful left bundle branch area pacing in patients with transthyretin cardiac amyloidosis presenting with atrioventricular block. Despite significant ventricular septal hypertrophy across all cases, left bundle branch area pacing was implemented effectively without complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Traditional pacing strategies in transthyretin cardiac amyloidosis, such as right ventricular pacing, have been associated with a reduced left ventricular ejection fraction and worsening heart failure. Although biventricular pacing has been explored, the supporting evidence remains limited and inconclusive. Recent studies have suggested that left bundle branch area pacing poses a lower risk of inducing heart failure than biventricular pacing. Our findings support the safety and efficacy of the left bundle branch area pacing in patients with transthyretin cardiac amyloidosis-related atrioventricular blocks and underscore its viability as a pacing strategy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae677","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T12:36:57Z","timestamp":1736944617000},"source":"Crossref","is-referenced-by-count":3,"title":["Left bundle branch area pacing in patients with transthyretin cardiac amyloidosis: a case series"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-7747","authenticated-orcid":false,"given":"Keisuke","family":"Miyajima","sequence":"first","affiliation":[{"name":"Department of Cardiology, Seirei Mikatahara General Hospital , 3453 Mikatahara-cho, Kita-ward, Hamamatsu, Shizuoka 433-8558 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakaba","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Seirei Mikatahara General Hospital , 3453 Mikatahara-cho, Kita-ward, Hamamatsu, Shizuoka 433-8558 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Hakamata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Seirei Mikatahara General Hospital , 3453 Mikatahara-cho, Kita-ward, Hamamatsu, Shizuoka 433-8558 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasukazu","family":"Takazawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Seirei Mikatahara General Hospital , 3453 Mikatahara-cho, Kita-ward, Hamamatsu, Shizuoka 433-8558 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Seirei Mikatahara General Hospital , 3453 Mikatahara-cho, Kita-ward, Hamamatsu, Shizuoka 433-8558 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Seirei Mikatahara General Hospital , 3453 Mikatahara-cho, Kita-ward, Hamamatsu, Shizuoka 433-8558 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine , Hamamatsu, Shizuoka 431-3192 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"2025012113064402900_ytae677-B1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/anec.12018","article-title":"The findings of electrocardiography in patients with cardiac amyloidosis","volume":"18","author":"Cheng","year":"2013","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2025012113064402900_ytae677-B2","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1093\/eurheartj\/ehx350","article-title":"Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement","volume":"38","author":"Casta\u00f1o","year":"2017","journal-title":"Eur Heart J"},{"key":"2025012113064402900_ytae677-B3","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1056\/NEJMoa1805689","article-title":"Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy","volume":"379","author":"Maurer","year":"2018","journal-title":"N Engl J Med"},{"key":"2025012113064402900_ytae677-B4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/pace.14894","article-title":"Feasibility and safety of left bundle branch area pacing in cardiac amyloidosis. 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