{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:51:01Z","timestamp":1753876261759,"version":"3.41.2"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pulmonary hypertension caused by extrinsic pulmonary vascular compression secondary to mediastinal neuroendocrine tumours is a very rare condition, posing a diagnostic challenge. There is no clear consensus regarding the best treatment strategy due to the lack of clinical data, leading to poor prognoses for these patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We present the case of a 38-year-old man hospitalized with signs of pulmonary hypertension and acute heart failure. He had experienced progressive dyspnoea over the 12 months prior to admission. Studies performed at our institution revealed dilation of the right heart chambers with right ventricular systolic dysfunction and pulmonary hypertension. Cardiac tomography showed extrinsic vascular compression, leading to emergency endovascular treatment for superior vena cava syndrome, followed by stent implantation in the pulmonary arteries and innominate vein. Further studies identified a mediastinal neuroendocrine tumour, for which chemotherapy was initiated, without clinical response. During outpatient follow-up, cardiac function worsened, and the patient died 48 months after symptoms onset due to a lung infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Pulmonary hypertension secondary to extrinsic vascular compression by mediastinal tumour is a rare condition that presents a diagnostic challenge. This case highlights the importance of considering oncological aetiology in patients with progressive dyspnoea and pulmonary vascular extrinsic compression. Despite early treatment, the prognosis for these patients remains poor.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae678","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T15:51:16Z","timestamp":1735660276000},"source":"Crossref","is-referenced-by-count":0,"title":["When the heart and tumours intertwine: pulmonary hypertension associated with a neuroendocrine tumour\u2014a case report"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0934-702X","authenticated-orcid":false,"given":"Maicol","family":"Cortez","sequence":"first","affiliation":[{"name":"Department of Cardiology, National Hospital Edgardo Rebagliati Martins , Avenida Edgardo Rebagliati 490, Jes\u00fas Mar\u00eda, 15072 Lima ,","place":["Per\u00fa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4822-4575","authenticated-orcid":false,"given":"Bryam","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Hospital Edgardo Rebagliati Martins , Avenida Edgardo Rebagliati 490, Jes\u00fas Mar\u00eda, 15072 Lima ,","place":["Per\u00fa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Mamani","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hospital Nacional Edgardo Rebagliati Martins, EsSalud , 490, Jes\u00fas Mar\u00eda, 15072 Lima ,","place":["Per\u00fa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8697-5673","authenticated-orcid":false,"given":"Flor","family":"de Mar\u00eda Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Hospital Nacional Edgardo Rebagliati Martins, EsSalud , 490, Jes\u00fas Mar\u00eda, 15072 Lima ,","place":["Per\u00fa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Hospital Nacional Edgardo Rebagliati Martins, EsSalud , 490, Jes\u00fas Mar\u00eda, 15072 Lima ,","place":["Per\u00fa"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"2025012113125875000_ytae678-B1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jacasi.2021.11.016","article-title":"Pulmonary hypertension caused by fibrosing mediastinitis","volume":"2","author":"Wang","year":"2022","journal-title":"JACC Asia"},{"key":"2025012113125875000_ytae678-B2","first-page":"101671","article-title":"A case of severe cancer-related pulmonary hypertension; an unexpected resolution","volume":"38","author":"Albaba","year":"2022","journal-title":"Respir Med Case Rep"},{"key":"2025012113125875000_ytae678-B3","doi-asserted-by":"crossref","first-page":"2200879","DOI":"10.1183\/13993003.00879-2022","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"61","author":"Humbert","year":"2023","journal-title":"Eur Respir J"},{"key":"2025012113125875000_ytae678-B4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1183\/13993003.01913-2018","article-title":"Haemodynamic definitions and updated clinical classification of pulmonary hypertension","volume":"53","author":"Simonneau","year":"2019","journal-title":"Eur Respir J"},{"key":"2025012113125875000_ytae678-B5","first-page":"325","article-title":"Atypical carcinoid: a rare finding of a man with mediastinal mass: a case report","volume":"12","author":"Xuan","year":"2020","journal-title":"Mol Clin Onc"},{"key":"2025012113125875000_ytae678-B6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.ecl.2018.04.011","article-title":"Lung and thymic carcinoids","volume":"47","author":"Hann","year":"2018","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2025012113125875000_ytae678-B7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1470-2045(04)01385-3","article-title":"Uncommon primary mediastinal tumours","volume":"5","author":"Macchiarini","year":"2004","journal-title":"Lancet Oncol"},{"key":"2025012113125875000_ytae678-B8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/14737140.2022.2052278","article-title":"Therapeutic options in thymomas and thymic carcinomas","volume":"22","author":"Muto","year":"2022","journal-title":"Expert Rev Anticancer Ther"},{"key":"2025012113125875000_ytae678-B9","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/MPA.0b013e3181ec124e","article-title":"The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems","volume":"39","author":"Klimstra","year":"2010","journal-title":"Pancreas"},{"key":"2025012113125875000_ytae678-B10","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jtho.2021.10.010","article-title":"The 2021 WHO classification of tumors of the thymus and mediastinum: what is new in thymic epithelial, germ cell, and mesenchymal tumors?","volume":"17","author":"Marx","year":"2022","journal-title":"J Thorac Oncol"},{"key":"2025012113125875000_ytae678-B11","first-page":"e12853","article-title":"Primary mediastinal neuroendocrine tumor: a case of atypical carcinoid","volume":"13","author":"Kosmas","year":"2021","journal-title":"Cureus"},{"key":"2025012113125875000_ytae678-B12","first-page":"285","article-title":"Evaluation of 342 cases of mediastinal\/thymic carcinoids collected from literature: a comparative study between typical carcinoids and atypical varieties","volume":"5","author":"Soga","year":"1999","journal-title":"Ann Thorac Cardiovasc Surg"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytae678\/61301398\/ytae678.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/9\/1\/ytae678\/61301398\/ytae678.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/9\/1\/ytae678\/61301398\/ytae678.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T13:13:19Z","timestamp":1737465199000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytae678\/7935370"}},"subtitle":[],"editor":[{"given":"Amir","family":"Khalifa","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Raheel","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Jan","family":"Henzel","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Benzoni","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,12,24]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12,24]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytae678","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2024,12,24]]},"article-number":"ytae678"}}