{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:39Z","timestamp":1753876239641,"version":"3.41.2"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Central venous catheter-related thrombosis (CRT) is a recognized complication, particularly in patients with underlying hypercoagulable states. This condition can precipitate several complications, including secondary infections, necessitating immediate and effective diagnosis and management.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>In this report, we present a case of a 13-day-old neonate admitted to the neonatal intensive care unit with severe respiratory distress, necessitating the insertion of a central venous catheter for optimal nutrition and treatment. Persistent fever and worsening general condition prompted further investigations, including echocardiography, which revealed a sizeable right atrial mass. Surgical removal of the mass was performed, and subsequent analysis identified thrombosis complicated by Aspergillus colonization. Postoperative management included anticoagulation and antifungal therapy, which were continued for 3 weeks until the patient\u2019s condition improved, leading to discharge.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This case highlights the importance of accurate differential diagnosis of cardiac masses, early recognition and management of CRT in neonates, and the need for timely treatment of opportunistic infections like invasive Aspergillosis for optimal outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf049","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T08:26:16Z","timestamp":1738571176000},"source":"Crossref","is-referenced-by-count":0,"title":["Right atrial thrombus in a neonate with Aspergillus colonization secondary to central venous catheter: a case report"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0411-4833","authenticated-orcid":false,"given":"Hassan","family":"El-Shirbiny","sequence":"first","affiliation":[{"name":"Cardiology Department, Kafrelsheikh University Hospital , El-Geish Street, Kafrelsheikh 33516 ,","place":["Egypt"]},{"name":"Cardiology Department, Kafrelsheikh University Faculty of Medicine , Kafrelsheikh 33516 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2735-6695","authenticated-orcid":false,"given":"Mohamed","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Cardiology Department, Kafrelsheikh University Hospital , El-Geish Street, Kafrelsheikh 33516 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6300-9988","authenticated-orcid":false,"given":"Mahmoud","family":"Gomaa","sequence":"additional","affiliation":[{"name":"Cardiology Department, Kafrelsheikh University Hospital , El-Geish Street, Kafrelsheikh 33516 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"2025021110555541000_ytaf049-B1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/1751143715618683","article-title":"Catheter-related thrombosis: a practical approach","volume":"17","author":"Wall","year":"2016","journal-title":"J Intensive Care Soc"},{"key":"2025021110555541000_ytaf049-B2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/annonc\/mdm350","article-title":"Thrombotic and infectious complications of central venous catheters in patients with hematological malignancies","volume":"19","author":"Boersma","year":"2008","journal-title":"Ann Oncol"},{"key":"2025021110555541000_ytaf049-B3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1086\/321887","article-title":"Detection of Aspergillus species in blood and bronchoalveolar lavage samples from immunocompromised patients by means of 2-step polymerase chain reaction: clinical results","volume":"33","author":"Buchheidt","year":"2001","journal-title":"Clin Infect Dis"},{"key":"2025021110555541000_ytaf049-B4","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020873","article-title":"Jugular venous catheter-associated thrombosis and fatal pulmonary embolism: a case report","volume":"99","author":"Wang","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"2025021110555541000_ytaf049-B5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1024\/0301-1526\/a000217","article-title":"Risk factors, management and primary prevention of thrombotic complications related to the use of central venous catheters","volume":"41","author":"Linnemann","year":"2012","journal-title":"Vasa"},{"key":"2025021110555541000_ytaf049-B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2024.109658","article-title":"From skin to syndrome: the progression of primary cutaneous aspergillosis to extremity compartment syndrome in a premature infant. Case report and review of the literature","volume":"119","author":"Ramos-Irizarry","year":"2024","journal-title":"Int J Surg Case Rep"},{"key":"2025021110555541000_ytaf049-B7","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41390-021-01842-7","article-title":"Invasive fungal infections in neonates: a review","volume":"91","author":"Weimer","year":"2022","journal-title":"Pediatr Res"},{"key":"2025021110555541000_ytaf049-B8","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10121088","article-title":"Cardiac masses: the role of cardiovascular imaging in the differential diagnosis","volume":"10","author":"Aggeli","year":"2020","journal-title":"Diagnostics (Basel, Switzerland)"},{"key":"2025021110555541000_ytaf049-B9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2214\/AJR.08.1694","article-title":"Atrial myxomas and thrombi: comparison of imaging features on CT","volume":"192","author":"Scheffel","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"2025021110555541000_ytaf049-B10","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1182\/blood-2003-06-2186","article-title":"Interactions of Aspergillus fumigatus with endothelial cells: internalization, injury, and stimulation of tissue factor activity","volume":"103","author":"Lopes Bezerra","year":"2004","journal-title":"Blood"},{"key":"2025021110555541000_ytaf049-B11","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13040764","article-title":"Intracardiac thrombi in preterm infants-a case study and review of the literature","volume":"13","author":"Gover","year":"2023","journal-title":"Diagnostics (Basel, Switzerland)"},{"key":"2025021110555541000_ytaf049-B12","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1016\/S0735-1097(03)00479-0","article-title":"Right heart thrombi in pulmonary embolism: results from the International Cooperative Pulmonary Embolism Registry","volume":"41","author":"Torbicki","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2025021110555541000_ytaf049-B13","doi-asserted-by":"publisher","DOI":"10.1186\/s43044-020-00112-x","article-title":"Management of a huge right atrial thrombus in a patient with multiple comorbidities","volume":"72","author":"Selwanos","year":"2020","journal-title":"Egypt Heart J"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytaf049\/61738566\/ytaf049.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/9\/2\/ytaf049\/61738566\/ytaf049.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/9\/2\/ytaf049\/61738566\/ytaf049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T10:56:24Z","timestamp":1739271384000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytaf049\/7997053"}},"subtitle":[],"editor":[{"given":"Rita","family":"Pavasini","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Dzan","family":"Horozic","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Federico","family":"Marchini","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Emmanouil","family":"Mantzouranis","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,2,1]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytaf049","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2025,2,1]]},"article-number":"ytaf049"}}