{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:51:21Z","timestamp":1753876281497,"version":"3.41.2"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Takotsubo syndrome is an uncommon condition in children, mainly triggered by physical stressors. However, it has never been described after a mitral valve surgery in this population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We present the case of a 14-year-old boy with a history of Loeys\u2013Dietz syndrome, who had previously undergone aortic root replacement due to an aortic aneurysm. He was admitted for elective mitral valve repair due to asymptomatic severe primary mitral regurgitation caused by bileaflet prolapse. Mitral valve repair was performed without incidences, but in the postoperative, he developed cardiogenic shock and cardiorespiratory arrest. Echocardiography showed severe left ventricular dysfunction with mid to distal diffuse hypokinesia, with better contractility in basal segments. Extracorporeal membrane oxygenation was required for 48\u2005h, after which his haemodynamic status improved, leading to a gradual reduction in supportive measures. Control echocardiogram showed partial recovery of the left ventricular function with improved contractility in apical segments. The patient could be discharged at 2 weeks. One month later, he remained asymptomatic, with a normal left ventricular ejection fraction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Takotsubo syndrome can be a life-threatening condition, with a higher prevalence of acute complications in male patients. Reports of this syndrome after cardiac surgery have mostly involved the mitral valve, which could be explained by the abrupt change in ventricular loading conditions and increase in afterload. The immediate postoperative use of epinephrine and dobutamine has been identified as a risk factor for the development of Takotsubo syndrome. Despite initially considered a benign entity, Takotsubo syndrome can be a life-threatening condition, with a mortality risk similar to patients presenting with acute coronary syndromes. Mitral valve surgery may serve as a trigger for Takotsubo syndrome and should be considered as a potential differential diagnosis in patients presenting with postoperative cardiogenic shock.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf167","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T02:38:51Z","timestamp":1744079931000},"source":"Crossref","is-referenced-by-count":1,"title":["Takotsubo syndrome following mitral valve surgery in a paediatric patient: a case report"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1162-8360","authenticated-orcid":false,"given":"Mar\u00eda Victoria","family":"Piovano","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Austral , Av. Per\u00f3n 1500, Pilar, Buenos Aires 1629 ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Cruz","family":"Ponceliz","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Hospital Universitario Austral , Av. Per\u00f3n 1500, Pilar, Buenos Aires 1629 ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Chiostri","sequence":"additional","affiliation":[{"name":"Pediatric Cardiovascular Surgery, Hospital Universitario Austral \u00a0 , Av. Per\u00f3n 1500, Pilar, Buenos Aires 1629 ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo Nuncio","family":"Vaccarino","sequence":"additional","affiliation":[{"name":"Institute of Cardiology and Cardiovascular Therapy, Hospital Universitario Austral , Av. Per\u00f3n 1500, Pilar, Buenos Aires 1629 ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kreutzer","sequence":"additional","affiliation":[{"name":"Pediatric Cardiovascular Surgery, Hospital Universitario Austral \u00a0 , Av. Per\u00f3n 1500, Pilar, Buenos Aires 1629 ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"2025042510264184100_ytaf167-B1","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/j.jacc.2018.07.072","article-title":"Stress cardiomyopathy diagnosis and treatment: JACC state-of-the-art review","volume":"72","author":"Medina de Chazal","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2025042510264184100_ytaf167-B2","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1093\/eurheartj\/ehy076","article-title":"International expert consensus document on Takotsubo syndrome (Part I): clinical characteristics, diagnostic criteria, and pathophysiology","volume":"39","author":"Ghadri","year":"2018","journal-title":"Eur Heart J"},{"key":"2025042510264184100_ytaf167-B3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ahj.2012.04.010","article-title":"In-hospital mortality among patients with Takotsubo cardiomyopathy: a study of the National Inpatient Sample 2008 to 2009","volume":"164","author":"Brinjikji","year":"2012","journal-title":"Am Heart J"},{"key":"2025042510264184100_ytaf167-B4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1053\/j.jvca.2013.09.005","article-title":"Takotsubo syndrome after mitral valve replacement: case report and brief review of the literature","volume":"29","author":"Pergolini","year":"2015","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"2025042510264184100_ytaf167-B5","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1111\/jocs.15626","article-title":"Risk factors for Takotsubo syndrome following cardiac surgery: a case-control study","volume":"36","author":"Kim","year":"2021","journal-title":"J Card Surg"},{"key":"2025042510264184100_ytaf167-B6","doi-asserted-by":"crossref","first-page":"1067444","DOI":"10.3389\/fcvm.2022.1067444","article-title":"Takotsubo cardiomyopathy after cardiac surgery: a case-series and systematic review of literature","volume":"9","author":"Laghlam","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"2025042510264184100_ytaf167-B7","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1017\/S1047951120002632","article-title":"Takotsubo cardiomyopathy in children","volume":"30","author":"Sendi","year":"2020","journal-title":"Cardiol Young"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytaf167\/62884954\/ytaf167.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/9\/4\/ytaf167\/62884954\/ytaf167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/9\/4\/ytaf167\/62884954\/ytaf167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T14:26:54Z","timestamp":1745591214000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytaf167\/8107790"}},"subtitle":[],"editor":[{"given":"Edoardo","family":"Zancanaro","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Ryaan","family":"El-Andari","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Faris","family":"Kad\u00edc","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,3,28]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytaf167","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,3,28]]},"article-number":"ytaf167"}}