{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:49:58Z","timestamp":1753876198906,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A small left ventricular cavity is one of the major limitations of HeartMate 3 implantation. Therefore, innovations in implantation techniques are required to expand the use of HeartMate 3, the only durable ventricular assist device approved by the US Food and Drug Administration for use in adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 65-year-old male was diagnosed with multiple myeloma (MM) and cardiac amyloidosis. Guideline-directed medical therapy was used to treat heart failure secondary to restrictive cardiomyopathy with a small left ventricle (LV). However, after three chemotherapy courses for MM, the patient developed refractory acute decompensated heart failure. He underwent urgent HeartMate 3 implantation as a bridge to chemotherapy. We adopted the left atrium-to-aorta configuration for HeartMate 3 implantation and performed trans-septal left atrial cannulation using a modified Intergard Woven vascular graft. After discharge, the patient resumed chemotherapy on post-operative day 172 and achieved complete response on post-operative day 259. At the time of writing this report, he has been supported with HeartMate 3 for 36 months, and no major adverse events have been recorded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>In most reports of trans-septal left atrial cannulation for durable ventricular assist device implantation, a 20-mm ringed Gore-Tex graft was used as the interposition conduit. Some technical difficulties with this graft have been described. Thus, we decided to modify the Intergard Woven graft as the interposition conduit. The favourable outcome in our patient could suggest the potential of extended support with the left atrium-to-aorta configuration of HeartMate 3 for patients with a small LV.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf225","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T08:35:51Z","timestamp":1746520551000},"source":"Crossref","is-referenced-by-count":0,"title":["Extended support of HeartMate 3 with transseptal left atrial cannulation using a modified wire-reinforced graft: a case report"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-5088","authenticated-orcid":false,"given":"Hsun-Yi","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, National Taiwan University Hospital , No. 7, Zhongshan S. Rd., Zhongzheng Dist., Taipei City 100225 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-5560","authenticated-orcid":false,"given":"Weng-Kin","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Center, Cathay General Hospital , No. 280, Sec. 4, Ren'ai Rd., Da'an Dist., Taipei City 106438 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0589-0757","authenticated-orcid":false,"given":"Heng-Wen","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, National Taiwan University Hospital , No. 7, Zhongshan S. Rd., Zhongzheng Dist., Taipei City 100225 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3846-8162","authenticated-orcid":false,"given":"Yih-Sharng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, National Taiwan University Hospital , No. 7, Zhongshan S. Rd., Zhongzheng Dist., Taipei City 100225 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"2025052601113755500_ytaf225-B1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.cardfail.2017.09.011","article-title":"Outcomes of restrictive and hypertrophic cardiomyopathies after LVAD: an INTERMACS analysis","volume":"23","author":"Patel","year":"2017","journal-title":"J Card Fail"},{"key":"2025052601113755500_ytaf225-B2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/MAT.0000000000001238","article-title":"Left ventricular assist device implantation in hypertrophic and restrictive cardiomyopathy: a systematic review","volume":"67","author":"Sreenivasan","year":"2021","journal-title":"ASAIO J"},{"key":"2025052601113755500_ytaf225-B3","doi-asserted-by":"crossref","first-page":"e007931","DOI":"10.1161\/CIRCHEARTFAILURE.120.007931","article-title":"Durable mechanical circulatory support in patients with amyloid cardiomyopathy: insights from INTERMACS","volume":"13","author":"Michelis","year":"2020","journal-title":"Circ Heart Fail"},{"key":"2025052601113755500_ytaf225-B4","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1016\/j.jaccas.2020.10.006","article-title":"Left ventricular assist device with a left atrial inflow cannula for hypertrophic cardiomyopathy","volume":"2","author":"Kiamanesh","year":"2020","journal-title":"JACC Case Rep"},{"key":"2025052601113755500_ytaf225-B5","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.jacc.2016.06.053","article-title":"AL (Light-chain) cardiac amyloidosis: a review of diagnosis and therapy","volume":"68","author":"Falk","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2025052601113755500_ytaf225-B6","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jaccao.2021.07.007","article-title":"ATTR cardiomyopathy meets multiple myeloma: the importance of cardiac biopsy","volume":"3","author":"Kanelidis","year":"2021","journal-title":"JACC CardioOncol"},{"key":"2025052601113755500_ytaf225-B7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCHEARTFAILURE.110.959288","article-title":"Left ventricular assist device therapy in patients with restrictive and hypertrophic cardiomyopathy","volume":"4","author":"Topilsky","year":"2011","journal-title":"Circ Heart Fail"},{"key":"2025052601113755500_ytaf225-B8","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/ejcts\/ezu233","article-title":"Biventricular assist device use in non-dilated hypertrophic cardiomyopathy","volume":"47","author":"Singh","year":"2015","journal-title":"Eur J Cardio Thorac Surg"},{"key":"2025052601113755500_ytaf225-B9","doi-asserted-by":"crossref","first-page":"S479","DOI":"10.1016\/j.healun.2019.01.1218","article-title":"Novel trans-septal left atrial VAD cannulation technique for hypertrophic\/restrictive cardiomyopathy","volume":"38","author":"Maeda","year":"2019","journal-title":"J Heart Lung Transplant"},{"key":"2025052601113755500_ytaf225-B10","doi-asserted-by":"crossref","first-page":"e231","DOI":"10.1016\/j.athoracsur.2018.04.065","article-title":"An alternative approach by HeartWare ventricular assist device in hypertrophic cardiomyopathy","volume":"106","author":"Maeda","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"2025052601113755500_ytaf225-B11","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1002\/ehf2.14039","article-title":"Two-year outcome of ventricular assist device via a modified left atrium to aorta approach in cardiac amyloidosis","volume":"9","author":"Lim","year":"2022","journal-title":"ESC Heart Fail"},{"key":"2025052601113755500_ytaf225-B12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.atssr.2022.10.015","article-title":"HeartMate 3 implantation through left atrial e-PTFE conduit for restrictive cardiomyopathy","volume":"1","author":"Guo","year":"2022","journal-title":"Ann Thorac Surg Short Rep"},{"key":"2025052601113755500_ytaf225-B13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.healun.2022.10.013","article-title":"An alternative approach of heartmate 3 implantation in restrictive cardiomyopathy","volume":"42","author":"MacIver","year":"2023","journal-title":"J Heart Lung Transplant"},{"key":"2025052601113755500_ytaf225-B14","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.healun.2022.12.004","article-title":"The 2023 international society for heart and lung transplantation guidelines for mechanical circulatory support: a 10- year update","volume":"42","author":"Saeed","year":"2023","journal-title":"J Heart Lung Transplant"}],"container-title":["European Heart Journal - 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