{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:32:01Z","timestamp":1754159521675,"version":"3.41.2"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hypercoagulable states may lead to vascular complications in both the systemic and pulmonary systems, and these conditions may even co-occur. Thrombosis of the native aortic valve, unlike thrombotic events on prosthetic valves, is a very rare condition that may result from thrombophilia and can mimic other valvular disorders. Most significantly, it can serve as a source of further embolic events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 48-year-old man, a smoker, diagnosed in the emergency department with a small acute pulmonary embolism, was referred to the cardiology department for further treatment. After a transthoracic echocardiogram showed regional contractility dysfunction of the left ventricle, the patient underwent coronary angiography. Following the detection of acute occlusion of the posterior descending branch of the right coronary artery, an effective balloon coronary angioplasty was performed. Due to the suspicion of embolic aetiology of the myocardial infarction, the diagnostic workup was expanded to include a transoesophageal echocardiogram, which revealed a pathological structure on the aortic valve. Ultimately, thrombosis of a normally structured native aortic valve, coexisting with a slight pulmonary embolism, was diagnosed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>The low incidence of native aortic valve thrombosis as a manifestation of thrombophilia, along with its transient nature, may lead to the underestimation of this clinical issue and presents challenges in diagnostic and treatment workflows, especially in case of co-occurring pulmonary embolism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf332","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T13:22:47Z","timestamp":1752326567000},"source":"Crossref","is-referenced-by-count":0,"title":["The co-occurrence of pulmonary embolism and aortic valve thrombosis complicated by myocardial infarction as a clinical manifestation of antithrombin III deficiency: a case report"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1209-7571","authenticated-orcid":false,"given":"Wojciech","family":"Kula","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital of the Ministry of the Interior and Administration , ul. Grenadier\u00f3w 3, Lublin 20-331 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Sus","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital of the Ministry of the Interior and Administration , ul. Grenadier\u00f3w 3, Lublin 20-331 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Wo\u0142yniak","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital of the Ministry of the Interior and Administration , ul. Grenadier\u00f3w 3, Lublin 20-331 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Ci\u0119\u017ckowska","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital of the Ministry of the Interior and Administration , ul. Grenadier\u00f3w 3, Lublin 20-331 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Drozd","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital of the Ministry of the Interior and Administration , ul. Grenadier\u00f3w 3, Lublin 20-331 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"2025072509311553300_ytaf332-B1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jacc.2014.04.063","article-title":"Paradoxical embolism","volume":"64","author":"Windecker","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2025072509311553300_ytaf332-B2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1177\/1358863X18755927","article-title":"Hypercoagulable states in arterial and venous thrombosis: when, how, and who to test?","volume":"23","author":"Carroll","year":"2018","journal-title":"Vascular Medicine"},{"key":"2025072509311553300_ytaf332-B3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2015.09.011","article-title":"Guidelines for the use of echocardiography in the evaluation of a cardiac source of embolism","volume":"29","author":"Saric","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"2025072509311553300_ytaf332-B4","doi-asserted-by":"publisher","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad625","article-title":"2023 ESC guidelines for the management of endocarditis","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur Heart J"},{"key":"2025072509311553300_ytaf332-B5","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jacc.2021.06.023","article-title":"The characteristics and outcomes of native aortic valve thrombosis: a systematic review","volume":"78","author":"Alajaji","year":"2021","journal-title":"JACC"},{"key":"2025072509311553300_ytaf332-B6","doi-asserted-by":"crossref","first-page":"1169.e3","DOI":"10.1016\/j.ajem.2008.12.006","article-title":"Simultaneous thromboses of double coronary arteries in a young male with antithrombin III deficiency","volume":"27","author":"Tu","year":"2009","journal-title":"Am J Emerg Med"},{"key":"2025072509311553300_ytaf332-B7","first-page":"868","article-title":"Antithrombin deficiency as a still underdiagnosed type of thrombophilia: a primer for internists","volume":"130","author":"Bravo-P\u00e9rez","year":"2020","journal-title":"Pol Arch Intern Med"},{"key":"2025072509311553300_ytaf332-B8","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1160\/TH08-09-0583","article-title":"Antithrombin Cambridge II (A384S) supports a role for antithrombin deficiency in arterial thrombosis","volume":"101","author":"Rold\u00e1n","year":"2009","journal-title":"Thromb Haemost"},{"key":"2025072509311553300_ytaf332-B9","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1182\/blood.2023021638","article-title":"How I treat the co-occurrence of venous and arterial thromboembolism: anticoagulation, antiplatelet therapy, or both?","volume":"143","author":"May","year":"2024","journal-title":"Blood"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytaf332\/63734763\/ytaf332.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/9\/7\/ytaf332\/63734763\/ytaf332.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/9\/7\/ytaf332\/63734763\/ytaf332.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T13:31:25Z","timestamp":1753450285000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytaf332\/8197970"}},"subtitle":[],"editor":[{"given":"Nidhi","family":"Madan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Muhammad Usman","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Jan","family":"Henzel","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Nicolo","family":"Sisti","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytaf332","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,7,1]]},"article-number":"ytaf332"}}