{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T23:26:34Z","timestamp":1784503594241,"version":"3.55.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Netherlands Organization for Scientific Research","award":["NWO\/ZonMw 0915016181013"],"award-info":[{"award-number":["NWO\/ZonMw 0915016181013"]}]},{"DOI":"10.13039\/100016244","name":"Health Foundation Limburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016244","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In structurally normal hearts, premature ventricular complexes (PVCs) are primarily driven by enhanced automaticity or afterdepolarization-dependent triggered activity. Traditionally, re-entrant excitation has only been associated with cardiac conditions involving scar formation, such as post-myocardial infarction or cardiac sarcoidosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We present a case of an asymptomatic 28-year-old patient with a high burden of monomorphic PVCs originating near the posteromedial papillary muscle. Left ventricular (LV) dilatation with reduced systolic function (ejection fraction 45%) was diagnosed as PVC-induced cardiomyopathy, given the absence of fibrosis and coronary artery disease. During an electrophysiological study, a 2-cm2 region was identified where abnormal Purkinje potentials (P1), exhibiting markedly reduced conduction velocity (0.88\u2005mm\/ms), consistently followed the rapid conduction via the left posterior fascicle (LPF). Local activation time velocity vectors of P1 pinpointed the earliest abnormal Purkinje activation at the proximal LPF. The impulse excited the distal one-third of the interventricular septum before conducting retrogradely to the LPF. Radiofrequency ablation targeted at the Purkinje-myocardial pivot point successfully eliminated the PVCs, restoring LV systolic function at follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Even in the absence of structural heart disease, delayed anterograde Purkinje conduction can facilitate monomorphic PVCs via re-excitation. This highlights the potential for targeted ablation at the distal Purkinje network as an effective treatment strategy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf335","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T14:14:25Z","timestamp":1752502465000},"source":"Crossref","is-referenced-by-count":2,"title":["Targeted ablation of the distal Purkinje-myocardium interface for premature ventricular complex\u2013induced cardiomyopathy by delayed Purkinje conduction-induced re-excitation: a case report"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-0132","authenticated-orcid":false,"given":"Rachel M A","family":"ter Bekke","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center+ , PO Box 5800, Maastricht, 6202 AZ ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"van Rooij","sequence":"additional","affiliation":[{"name":"Biosense Webster, Johnson & Johnson MedTech , Computerweg 14, 3821 AB, Amersfoort ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2652-1598","authenticated-orcid":false,"given":"Paul G A","family":"Volders","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center+ , PO Box 5800, Maastricht, 6202 AZ ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9l\u00e8ze","family":"Hocini","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic Unit, Bordeaux University Hospital (CHU) , Pessac F-33600 ,","place":["France"]},{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Universit\u00e9 , Pessac-Bordeaux F-33600 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"2025080112530409700_ytaf335-B1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fphys.2020.00406","article-title":"Pathophysiological mechanisms of premature ventricular complexes","volume":"11","author":"Hoogendijk","year":"2020","journal-title":"Front Physiol"},{"key":"2025080112530409700_ytaf335-B2","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1111\/jce.15120","article-title":"Mechanism of premature ventricular complexes in a patient with ischemic cardiomyopathy","volume":"32","author":"Takagi","year":"2021","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2025080112530409700_ytaf335-B3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.hrthm.2024.01.035","article-title":"Successful ablation of premature ventricular contractions from \u201clate\u201d activation site in cardiac sarcoidosis: evidence suggestive of a reentrant mechanism","volume":"21","author":"Shinoda","year":"2024","journal-title":"Heart Rhythm"},{"key":"2025080112530409700_ytaf335-B4","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.hrthm.2023.07.055","article-title":"How to perform Purkinje tissue ablation for the treatment of idiopathic VF","volume":"20","author":"Duchateau","year":"2023","journal-title":"Heart Rhythm"},{"key":"2025080112530409700_ytaf335-B5","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1161\/01.RES.82.10.1063","article-title":"Purkinje-muscle reentry as a mechanism of polymorphic ventricular arrhythmias in a 3-dimensional model of the ventricles","volume":"82","author":"Berenfeld","year":"1998","journal-title":"Circ Res"},{"key":"2025080112530409700_ytaf335-B6","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.hrcr.2020.09.010","article-title":"Ventricular fibrillation after ablation of a benign arrhythmia. 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