{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:04:39Z","timestamp":1785150279273,"version":"3.55.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fulminant eosinophilic myocarditis (EM) has a poor prognosis. Acute severe mitral regurgitation (MR) is a life-threatening complication of EM: however, no established treatment thereof exists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>Herein, we report a case of a 70-year-old woman diagnosed with fulminant EM. She was in cardiogenic shock and treatment was initiated with an implanted intra-aortic balloon pump in addition to steroids and inotropes. Functional MR gradually worsened, and cardiogenic shock did not improve. Our cardiology team discussed the treatment plan and performed transcatheter mitral valve repair (TMVr). Immediately after the procedure, MR was well-controlled, and the patient\u2019s hemodynamics improved dramatically. After discharge, there was no recurrence of heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We identified two important clinical issues: first, acute functional MR requiring invasive treatment can be associated with fulminant EM; and second, TMVr is useful as an invasive treatment strategy for such MR. Although MR caused by EM improves with pharmacological therapies in many cases, invasive treatment strategies may be required in some case, as seen in this case. Compared with surgeries, TMVr is less invasive and carries a lower risk of postoperative low cardiac output syndrome compared with surgical procedures when MR is well-controlled. If the response to pharmacological therapies is poor, early TMVr should be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf353","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T11:47:23Z","timestamp":1753357643000},"source":"Crossref","is-referenced-by-count":1,"title":["Successful transcatheter mitral valve repair for mitral regurgitation complicating fulminant eosinophilic myocarditis: a case report"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5450-1329","authenticated-orcid":false,"given":"Yudai","family":"Shiwaku","sequence":"first","affiliation":[{"name":"Division of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University , 2-1-1-1, Midorigaoka-higashi, Asahikawa 0788510 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Aonuma","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University , 2-1-1-1, Midorigaoka-higashi, Asahikawa 0788510 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Kitani","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University , 2-1-1-1, Midorigaoka-higashi, Asahikawa 0788510 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University , 2-1-1-1, Midorigaoka-higashi, Asahikawa 0788510 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University , 2-1-1-1, Midorigaoka-higashi, Asahikawa 0788510 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"2025112200420143000_ytaf353-B1","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.jacc.2017.09.023","article-title":"Eosinophilic myocarditis: characteristics, treatment, and outcomes","volume":"70","author":"Brambatti","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2025112200420143000_ytaf353-B2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.hfc.2005.06.013","article-title":"Eosinophilic myocarditis","volume":"1","author":"Ginsberg","year":"2005","journal-title":"Heart Fail Clin"},{"key":"2025112200420143000_ytaf353-B3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.icvts.2004.02.018","article-title":"Severe mitral regurgitation in acute eosinophilic endomyocarditis: repair or replacement?","volume":"3","author":"Tang","year":"2004","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"2025112200420143000_ytaf353-B4","doi-asserted-by":"crossref","first-page":"e228951","DOI":"10.1136\/bcr-2018-228951","article-title":"Mitral and tricuspid valve repair in hypereosinophilic syndrome","volume":"12","author":"Al-Kaisey","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2025112200420143000_ytaf353-B5","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/hrt.45.6.729","article-title":"Surgical treatment of L\u00f6ffler's eosinophilic endocarditis","volume":"45","author":"Ik\u00e4heimo","year":"1981","journal-title":"Br Heart J"},{"key":"2025112200420143000_ytaf353-B6","first-page":"95","article-title":"Complete resolution of severe secondary mitral regurgitation accompanying eosinophilic myocarditis due to immunosuppressive treatment","volume":"25","author":"Takahara","year":"2021","journal-title":"J Cardiol Cases"},{"key":"2025112200420143000_ytaf353-B7","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/ehf2.13881","article-title":"A case of vaccine-associated myocarditis following pneumococcal immunization leading to acute mitral regurgitation","volume":"9","author":"Yamamoto","year":"2022","journal-title":"ESC Heart Fail"},{"key":"2025112200420143000_ytaf353-B8","first-page":"108","article-title":"Severe mitral regurgitation caused by eosinophilic endocarditis","volume":"10","author":"Van Dongen","year":"2014","journal-title":"J Cardiol Cases"},{"key":"2025112200420143000_ytaf353-B9","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/01.CIR.67.3.572","article-title":"Two-dimensional echocardiographic assessment of the idiopathic hypereosinophilic syndrome. 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