{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T04:43:28Z","timestamp":1758343408916,"version":"3.44.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cardiac laminopathies, associated with mutations in the LMNA gene, are a rare inherited disorder characterized by a broad range of clinical manifestations. There are currently no data on the association between supraventricular re-entrant tachycardias and LMNA-related cardiomyopathy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 26-year-old male presented with either wide-QRS tachycardia with a left bundle branch block (LBBB) pattern or narrow QRS tachycardia, as well as a history of palpitations since age 15. Echocardiography showed no overt structural heart disease. Electrophysiological studies confirmed the diagnosis of orthodromic atrioventricular re-entrant tachycardia mediated by a concealed left posterolateral accessory pathway (AP), with transient LBBB and dual AV-node physiology, characterized by single echo beats. A short-run, asymptomatic episode of atrial fibrillation was induced. Cardiac magnetic resonance (CMR) imaging demonstrated myocardial hyperaemia, subepicardial late gadolinium enhancement, and a small pericardial effusion, initially interpreted as myocarditis according to the modified Lake Louise criteria. A family history of pacemaker implantation and cardiac death at age 65 of the patient\u2019s grandfather, a history of re-entrant arrhythmia recurrence following ablation, and further CMR deteriorations led to genetic counselling. Genetic testing identified a heterozygous pathogenic variant in the LMNA gene (NM_170707.3.456_457insTCTC, NP_733821.1.Glu154GlnfsX2), classified as likely pathogenic and associated with laminopathy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This case raises the question of whether the combination of re-entrant arrhythmias is coincidental or an early indicator of LMNA-related cardiomyopathy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf417","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T03:50:58Z","timestamp":1756439458000},"source":"Crossref","is-referenced-by-count":0,"title":["Reciprocated tachycardias in cardiac laminopathy: a clinical case report"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1865-8102","authenticated-orcid":false,"given":"Evgeny","family":"Zhelyakov","sequence":"first","affiliation":[{"name":"Pirogov Russian National Research Medical University Department of Cardiovascular Surgery, , bldg 6 Ostrovityaniva ulitsa, Moscow 117513 ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7766-1251","authenticated-orcid":false,"given":"Natalia","family":"Sonicheva-Paterson","sequence":"additional","affiliation":[{"name":"Tenaya Therapeuticals , Oyster Point Blvd., Suite 500. South San Francisco, CA 94080 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7795-9709","authenticated-orcid":false,"given":"Svetlana","family":"Aleksandrova","sequence":"additional","affiliation":[{"name":"A. N. Bakulev National Medical Research Center for Cardiovascular Surgery, bld 135, Rublyovskoe shosse, Moscow 121552, Russia Magnetic Resonance Imaging Department,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5470-4969","authenticated-orcid":false,"given":"Viktor","family":"Tcivkovskii","sequence":"additional","affiliation":[{"name":"JSC Medicine Surgery Department, , Bld 10 2-Tverskoy-Yamskoy pereulok, Moscow 125047, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1908-9802","authenticated-orcid":false,"given":"Andrei","family":"Ardashev","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University , 303E Chicago Ave, Ward 1-003, Chicago, IL 60611 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"2025091917342745800_ytaf417-B1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1080\/19491034.2018.1489195","article-title":"Updated clinical overview on cardiac laminopathies: an electrical and mechanical disease","volume":"9","author":"Peretto","year":"2018","journal-title":"Nucleus"},{"key":"2025091917342745800_ytaf417-B2","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.jacc.2016.08.058","article-title":"Long-term arrhythmic and nonarrhythmic outcomes of lamin A\/C mutation carriers","volume":"68","author":"Kumar","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2025091917342745800_ytaf417-B3","doi-asserted-by":"crossref","first-page":"e013145","DOI":"10.1161\/CIRCEP.124.013145","article-title":"Electrophysiological phenotype\u2013genotype study of sustained monomorphic ventricular tachycardia in inherited, high arrhythmic risk, left ventricular cardiomyopathy","volume":"17","author":"Cabrera-Borrego","year":"2024","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2025091917342745800_ytaf417-B4","doi-asserted-by":"crossref","first-page":"e190010","DOI":"10.1148\/ryct.2019190010","article-title":"Comparison of original and 2018 Lake Louise criteria for diagnosis of acute myocarditis: results of a validation cohort","volume":"1","author":"Luetkens","year":"2019","journal-title":"Radiol Cardiothorac Imaging"},{"key":"2025091917342745800_ytaf417-B5","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.recesp.2024.02.014","article-title":"Diagnosis and treatment of myocarditis and inflammatory cardiomyopathy. 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