{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:35:58Z","timestamp":1784266558661,"version":"3.55.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Post-infarction ventricular septal defect (VSD) is a rare but life-threatening complication of myocardial infarction, in severe cases needing heart transplantation. The Aeson Total Artificial Heart (TAH), a bioprosthetic device designed to replace both ventricles, offers an alternative for patients unsuitable for conventional therapies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 69-year-old male presented in cardiogenic shock following an inferior wall ST-elevation myocardial infarction complicated by a large VSD. Initial support included extracorporeal life system. Surgical repair was unfeasible due to the defect\u2019s size and proximity to the atrioventricular valve, leaving insufficient rim for septal reconstruction. Total artificial heart implantation was the only viable option, used as bridge-to-decision therapy given the patient\u2019s advanced age. Post-operative recovery was prolonged, but the patient was successfully transferred to an inpatient rehabilitation facility, where structured physiotherapy, endurance, resistance, and mobility training led to significant functional improvement. Close collaboration with a mechanical circulatory support perfusionist resolved recurring TAH alarms related to intraventricular pressure and communication issues adapting the diuretic and antihypertensive medication. The patient was discharged home in stable condition, achieving substantial physical recovery and independence in managing the device.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>The Aeson TAH proved to be a safe and effective therapy, in particular, as bridge-to-decision therapy in this complex case of post-infarction VSD. Inpatient cardiac rehabilitation played a pivotal role in optimizing physical recovery, managing device-related challenges, and preparing the early transition to an independent living. This case highlights the potential of advanced bioprosthetic solutions and the benefits of a structured rehabilitation system in managing severe cardiac conditions. Further research is needed to evaluate the long-term outcomes and broader applicability of the Aeson TAH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf478","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T02:03:47Z","timestamp":1758333827000},"source":"Crossref","is-referenced-by-count":1,"title":["Inpatient cardiac rehabilitation after implantation of a total artificial heart (Aeson device CARMAT) in case of ventricular septal defect after infarction"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6872-1736","authenticated-orcid":false,"given":"Raluca","family":"Fiebiger","sequence":"first","affiliation":[{"name":"Clinic for Cardiology, Median Rehabilitation Center Schmannewitz , Waldstr. 4, 04774 Schmannewitz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Dashkevich","sequence":"additional","affiliation":[{"name":"Clinic for Cardiac Surgery, Heart Center Leipzig , Str\u00fcmpellstr. 39, 04289 Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Nozdrzykowski","sequence":"additional","affiliation":[{"name":"Clinic for Cardiac Surgery, Heart Center Leipzig , Str\u00fcmpellstr. 39, 04289 Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Jozwiak-Nozdrzykowska","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology, Heart Center Leipzig , Str\u00fcmpellstr. 39, 04289 Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erind","family":"Gjermeni","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology, Median Rehabilitation Center Schmannewitz , Waldstr. 4, 04774 Schmannewitz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"2025100401573844900_ytaf478-B1","first-page":"e9725","article-title":"A rare complication of myocardial infarction: ventricular septal defect","volume":"12","author":"Elkattawy","year":"2020","journal-title":"Cureus"},{"key":"2025100401573844900_ytaf478-B2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/01.CIR.101.1.27","article-title":"Risk factors, angiographic patterns, and outcomes in patients with ventricular septal defect complicating acute myocardial infarction. GUSTO-I (Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries) trial investigators","volume":"101","author":"Crenshaw","year":"2000","journal-title":"Circulation"},{"key":"2025100401573844900_ytaf478-B3","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.athoracsur.2012.04.020","article-title":"Surgical repair of ventricular septal defect after myocardial infarction: outcomes from the Society of Thoracic Surgeons National Database","volume":"94","author":"Arnaoutakis","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"2025100401573844900_ytaf478-B4","first-page":"59","article-title":"Transcatheter closure of post-myocardial infarction ventricular septal rupture","volume":"6","author":"Assenza","year":"2013","journal-title":"Circulation"},{"key":"2025100401573844900_ytaf478-B5","doi-asserted-by":"crossref","first-page":"1211365","DOI":"10.3389\/fcvm.2023.1211365","article-title":"Case report-CARMAT: the first experience with the Aeson bioprosthetic total artificial heart as a bridge to transplantation in a case of post-infarction ventricular septal rupture","volume":"10","author":"Huenges","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"2025100401573844900_ytaf478-B6"},{"key":"2025100401573844900_ytaf478-B7","author":"CARMAT SA"},{"key":"2025100401573844900_ytaf478-B8","doi-asserted-by":"crossref","first-page":"e02914","DOI":"10.1016\/j.heliyon.2019.e02914","article-title":"Hemocompatibility and safety of the Carmat Total Artifical Heart hybrid membrane","volume":"5","author":"Richez","year":"2019","journal-title":"Heliyon"},{"key":"2025100401573844900_ytaf478-B9"},{"key":"2025100401573844900_ytaf478-B10","first-page":"77","author":"Abreu","year":"2019"},{"key":"2025100401573844900_ytaf478-B11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/HCR.0000000000000842","article-title":"Prehabilitation using a cardiac rehabilitation program for a patient with a total artificial heart prior to heart transplantation","volume":"44","author":"Racodon","year":"2024","journal-title":"J Cardiopulm Rehabil Prev"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytaf478\/64322170\/ytaf478.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/9\/10\/ytaf478\/64322170\/ytaf478.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/9\/10\/ytaf478\/64322170\/ytaf478.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:57:42Z","timestamp":1759557462000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytaf478\/8258189"}},"subtitle":[],"editor":[{"given":"Jan","family":"Henzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Mohammed Shahbaaz","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Rafael","family":"Vidal-Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Franca","family":"Morselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytaf478","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,19]]},"article-number":"ytaf478"}}