{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:59:05Z","timestamp":1762268345040,"version":"build-2065373602"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Mexican National Council for Science and Technology","doi-asserted-by":"publisher","award":["845144"],"award-info":[{"award-number":["845144"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy; however, it is a very rare condition among twins. A mismatch between the phenotype and clinical course has been identified, even in the presence of apparently identical genotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A pair of male monozygotic-diamniotic twins of 17 years old with a mismatch in HCM clinical expression is informed. Both twins have the same pathogenic variant [c.1816G&amp;gt;A (p.Val606Met)] located in MYH7, a gene that encodes an essential component in the contraction of cardiac muscle. The twins presented obstructive basal anteroseptal vs. non-obstructive medium apical HCM and different clinical courses (non-fatal sudden cardiac death vs. asymptomatic). It is hypothesized that twin-to-twin transfusion syndrome could be implied in the different phenotypes due to prenatal history, but other genetic and epigenetic factors can be implied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Despite carrying the same pathogenic variant, the phenotypical presentation and clinical course vary widely, despite a similar risk profile, suggesting the influence of genetic\/epigenetic and environmental factors on disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf522","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:18:40Z","timestamp":1761743920000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypertrophic cardiomyopathy in identical twins: a case report with mismatch between genotype and phenotype"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7294-7330","authenticated-orcid":false,"given":"Manlio F","family":"M\u00e1rquez-Murillo","sequence":"first","affiliation":[{"name":"Department of Electrocardiology, National Institute of Cardiology Ignacio Ch\u00e1vez , Juan Badiano 1, Col. Belisario Dom\u00ednguez\u2014Secci\u00f3n XVI, Tlalpan, Mexico City 14080, Mexico"},{"name":"Arrhythmia Center, American British Cowdray Medical Center , Sur 136-116, Col. Las Am\u00e9ricas, \u00c1lvaro Obreg\u00f3n, Mexico City 01120, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2316-0723","authenticated-orcid":false,"given":"Juan P","family":"Casillas-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology, National Institute of Cardiology Ignacio Ch\u00e1vez , Juan Badiano 1, Col. Belisario Dom\u00ednguez\u2014Secci\u00f3n XVI, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4974-7802","authenticated-orcid":false,"given":"Carmen A","family":"S\u00e1nchez-Contreras","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology, National Institute of Cardiology Ignacio Ch\u00e1vez , Juan Badiano 1, Col. Belisario Dom\u00ednguez\u2014Secci\u00f3n XVI, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7032-4348","authenticated-orcid":false,"given":"Armando","family":"Totomoch-Serra","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology, National Institute of Cardiology Ignacio Ch\u00e1vez , Juan Badiano 1, Col. Belisario Dom\u00ednguez\u2014Secci\u00f3n XVI, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9903-3375","authenticated-orcid":false,"given":"Dennys A","family":"Mas-Bautista","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology, National Institute of Cardiology Ignacio Ch\u00e1vez , Juan Badiano 1, Col. Belisario Dom\u00ednguez\u2014Secci\u00f3n XVI, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1654-9669","authenticated-orcid":false,"given":"Roberto","family":"Cano-Zarate","sequence":"additional","affiliation":[{"name":"Department of Cardiac Magnetic Resonance, National Institute of Cardiology Ignacio Ch\u00e1vez , Juan Badiano 1, Col. 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