{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T18:19:38Z","timestamp":1763489978403,"version":"3.45.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alternating cycles of hypertension, sustained hypotension, and heart rate (HR) variability, manifesting as an inverted pattern of Takotsubo cardiomyopathy (ITC) and pulmonary embolism (PE) due to an underlying previously undiagnosed pheochromocytoma (Pheo), is a rare and complex clinical presentation. To date, only two previous reports have described this triad. Despite the absence of established guidelines for managing blood pressure (BP) and HR fluctuations in patients with Pheo, understanding the interplay between these conditions is crucial for improving patient outcomes and optimizing treatment strategies. This case report highlights the diagnostic challenges and the need for further investigation into effective management approaches in such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>We present a case of a 68-year-old man hospitalized for acute chest pain and BP and HR fluctuations. The clinical work-up revealed the coexistence of ITC, PE, and Pheo. The patient was successfully treated with continuous volume expansion and selective \u03b11-adrenergic blockade, avoiding vasodilators and renin-angiotensin-aldosterone inhibitors. Perioperative administration of oral doxazosin and bisoprolol allowed a successful laparoscopic right adrenalectomy after 3-month anticoagulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Despite the lack of established recommendations for managing BP and HR fluctuations in patients with Pheo, the coexistence of PE further complicates the clinical management of this condition, suddenly modifying the haemodynamic status and increasing the risk of major bleeding events from the neoplastic mass. Patients presenting with ITC, PE, and Pheo require a multidisciplinary approach involving a cardiologist, hypertension specialist, and surgeon to resolve this intriguing clinical condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf574","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:12:17Z","timestamp":1761829937000},"source":"Crossref","is-referenced-by-count":0,"title":["A case report of blood pressure fluctuation, inverted Takotsubo cardiomyopathy, and pulmonary embolism: searching for a link"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2358-7759","authenticated-orcid":false,"given":"Alberto","family":"Mazza","sequence":"first","affiliation":[{"name":"Internal Medicine and ESH Excellence Hypertension Center, Santa Maria degli Angeli General Hospital , Piazzale degli Etruschi, 6, Adria (Rovigo) 45011 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