{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:04:58Z","timestamp":1764871498513,"version":"3.46.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pericardial masses are rare disease requiring incremental diagnostic workout to differentiate benignant from malignant lesions. No solid evidence exists regarding their management, and their treatment requires a case-by-case evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A 54-year-old man was diagnosed with a pericardial mass. After performing cardiac magnetic resonance and computed tomography, a high suspicion of malignancy was raised. Positron emission tomography and pericardial biopsy confirmed the presence of a primary histiocytic sarcoma. After multidisciplinary evaluation, the mass was considered not suitable for surgical removal, and a neoadjuvant chemotherapy strategy was started. The first chemotherapy regimen\u2014consisting of cyclophosphamide, doxorubicin, etoposide, vincristine, and methylprednisolone\u2014was not effective. Therefore, a second, more aggressive, regimen consisting of cladribine, cytarabine, granulocyte-colony stimulating factor, and mitoxantrone was started. Following the first cycle, the patient developed bone marrow aplasia and septic shock leading to the exitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Histiocytic sarcomas primarily involving the heart are extremely rare. Surgical excision represents the first therapeutic choice when feasible. When not pursuable, a neoadjuvant therapy is preferred, although no consensus exists regarding the chemotherapy regimen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf594","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T12:38:08Z","timestamp":1764592688000},"source":"Crossref","is-referenced-by-count":0,"title":["A case report of histiocytic sarcoma mimicking acute pericarditis"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4583-280X","authenticated-orcid":false,"given":"Mattia","family":"Corian\u00f2","sequence":"first","affiliation":[{"name":"Cardiology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua , Via N. Giustiniani 2, 35128 Padua ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niccol\u00f2","family":"Siviero","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua , Via N. Giustiniani 2, 35128 Padua ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Gasparetto","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Ospedale Ca\u2019 Foncello , Viale Vittorio Veneto 10, 31100 Treviso ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"2025120413010401300_ytaf594-B1","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","article-title":"2022 ESC guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur Heart J"},{"key":"2025120413010401300_ytaf594-B2","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1136\/heartjnl-2014-306364","article-title":"Cardiac masses and tumours","volume":"102","author":"Basso","year":"2016","journal-title":"Heart"},{"key":"2025120413010401300_ytaf594-B3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.athoracsur.2016.10.054","article-title":"Improved outcomes with the evolution of a neoadjuvant chemotherapy approach to right heart sarcoma","volume":"104","author":"Abu Saleh","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"2025120413010401300_ytaf594-B4","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jaccao.2024.09.006","article-title":"Multimodality imaging in the diagnostic work-up of patients with cardiac masses","volume":"6","author":"Angeli","year":"2024","journal-title":"JACC CardioOncol"},{"key":"2025120413010401300_ytaf594-B5","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1016\/j.jcmg.2020.03.021","article-title":"Diagnostic accuracy of cardiac computed tomography and 18-F fluorodeoxyglucose positron emission tomography in cardiac masses","volume":"13","author":"D\u2019Angelo","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"2025120413010401300_ytaf594-B6","author":"ESMO"},{"key":"2025120413010401300_ytaf594-B7","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1182\/blood-2016-01-690636","article-title":"Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages","volume":"127","author":"Emile","year":"2016","journal-title":"Blood"},{"key":"2025120413010401300_ytaf594-B8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1182\/blood-2017-10-812495","article-title":"Histiocytic sarcoma: a population-based analysis of incidence, demographic disparities, and long-term outcomes","volume":"131","author":"Kommalapati","year":"2018","journal-title":"Blood"},{"key":"2025120413010401300_ytaf594-B9","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/RLU.0000000000001041","article-title":"Enhanced CT and FDG PET\/CT in histiocytic sarcoma of the pericardium","volume":"41","author":"Dong","year":"2016","journal-title":"Clin Nucl Med"},{"key":"2025120413010401300_ytaf594-B10","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1076-7460.2007.05207.x","article-title":"Histiocytic sarcoma presenting as left ventricular mass demonstrated by two-dimensional echocardiography","volume":"16","author":"Thattassery","year":"2007","journal-title":"Am J Geriatr Cardiol"},{"key":"2025120413010401300_ytaf594-B11","first-page":"e25814","article-title":"Histiocytic sarcoma: clinical features and outcomes of patients treated at a tertiary cancer care center","volume":"14","author":"Susan Joy Philip","year":"2022","journal-title":"Cureus"},{"key":"2025120413010401300_ytaf594-B12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jons.2017.05.007","article-title":"An extremely rare neoplasm, histiocytic sarcoma: a report of two cases with an aggressive clinical course","volume":"3","author":"Kayikcioglu","year":"2017","journal-title":"J Oncol Sci"},{"key":"2025120413010401300_ytaf594-B13","first-page":"728260","article-title":"Successful treatment of multifocal histiocytic sarcoma occurring after renal transplantation with cladribine, high-dose cytarabine, G-CSF, and mitoxantrone (CLAG-M) followed by allogeneic hematopoietic stem cell transplantation","volume":"2015","author":"Tomlin","year":"2015","journal-title":"Case Rep Hematol"}],"container-title":["European Heart Journal - 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