{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:20:49Z","timestamp":1768620049870,"version":"3.49.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infective endocarditis (IE) is an uncommon but potentially fatal disease, with an incidence of 13.8 per 100 000 and persistent high mortality (15\u201330%). In 10\u201320% of cases, cultures remain negative and additional serological testing for infectious and non-bacterial endocarditis is required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>We report a case of a 25-year-old North African man with a history of lupus nephritis presenting with progressive dyspnoea, retrosternal pain, and fever. Transthoracic echocardiography showed extensive calcifications on the aortic valve with severe aortic regurgitation. Prior echocardiograms had already documented a large aortic valve calcification, which was not considered suspicious for IE on previous FDG-positron emission tomography scan. However, a transoesophageal echocardiogram at admission revealed a functional bicuspid aortic valve with a large vegetation and severe left ventricular dysfunction. The patient rapidly deteriorated into beginning cardiogenic shock, necessitating emergency mechanical aortic valve replacement. Blood cultures remained negative, but serology testing revealed elevated Bartonella henselae IgG (\u22651:1280) with positive polymerase chain reaction for Bartonella species on the resected valve. B. henselae, known as the causative pathogen of \u2018cat-scratch disease\u2019, was identified as the aetiological pathogen of blood culture\u2013negative IE (BCNIE). The patient was successfully treated with doxycycline and gentamicin, in combination with guideline-directed medical therapy for heart failure and cardiac resynchronization therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case illustrates the diagnostic challenges of BCNIE. Serologic and molecular testing should be pursued when cultures remain negative. Multi-disciplinary management, early surgical intervention, appropriate antibiotic treatment, and optimized heart failure therapy in IE presenting with acute heart failure can improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf643","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:13:21Z","timestamp":1765372401000},"source":"Crossref","is-referenced-by-count":0,"title":["Scratches of danger: from\n                    <i>Bartonella<\/i>\n                    to heart failure in a young patient\u2014a case report"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3021-9798","authenticated-orcid":false,"given":"Laura","family":"Braeckeveldt","sequence":"first","affiliation":[{"name":"ZAS Middelheim , Lindendreef 1, Antwerpen 2020 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the task force on the management of endocarditis of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and the European Ass","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur Heart J"},{"key":"2026011610420673100_ytaf643-B2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/archinternmed.2008.603","article-title":"Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the international collaboration on endocarditis\u2013prospective cohort study","volume":"169","author":"Murdoch","year":"2009","journal-title":"Arch Intern Med"},{"key":"2026011610420673100_ytaf643-B3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/cid\/ciad271","article-title":"The 2023 Duke-international society for cardiovascular infectious diseases criteria for infective endocarditis: updating the modified Duke 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