{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:59:21Z","timestamp":1768622361692,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sports participation in patients with inherited cardiac conditions remains a major challenge, particularly when balancing arrhythmic risk against quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A case of a 38-year-old recreational athlete diagnosed with hypertrophic cardiomyopathy (HCM) is described. A comprehensive assessment was performed, including electrocardiogram, echocardiography, exercise stress testing, Holter monitoring, and cardiac magnetic resonance, which revealed asymmetric non-obstructive HCM with extensive late gadolinium enhancement. Genetic testing identified two missense variants in MYBPC3, one of which was reclassified as likely pathogenic. Risk stratification using European Society of Cardiology (ESC) and American Heart Association\/American College of Cardiology (AHA\/ACC) calculators demonstrated a 5.73% 5-year risk of sudden cardiac death (SCD). A subcutaneous implantable cardioverter-defibrillator was implanted after a shared decision-making process, allowing the patient to continue recreational sport while avoiding competitive athletics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case highlights the value of multimodal imaging, genetic testing, and guideline-based SCD risk stratification in guiding individualized management of athletes with HCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaf671","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T12:54:19Z","timestamp":1766235259000},"source":"Crossref","is-referenced-by-count":0,"title":["A case report in hypertrophic cardiomyopathy in a recreational athlete: multimodality risk assessment, genetic insights, and shared decision-making"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-7028","authenticated-orcid":false,"given":"Luis Enrique","family":"Gomez","sequence":"first","affiliation":[{"name":"Hospital de Agudos Juan A. Fern\u00e1ndez , Av. Cervi\u00f1o 3356, CP: 1425AGP, Ciudad Autonoma de Buenos Aires ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana","family":"Aversa","sequence":"additional","affiliation":[{"name":"Hospital de Agudos Juan A. Fern\u00e1ndez , Av. Cervi\u00f1o 3356, CP: 1425AGP, Ciudad Autonoma de Buenos Aires ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0626-7657","authenticated-orcid":false,"given":"Maria Mercedes","family":"Saenz Tejeira","sequence":"additional","affiliation":[{"name":"Hospital de Agudos Juan A. Fern\u00e1ndez , Av. Cervi\u00f1o 3356, CP: 1425AGP, Ciudad Autonoma de Buenos Aires ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-4790","authenticated-orcid":false,"given":"Paula","family":"Buonfiglio","sequence":"additional","affiliation":[{"name":"Hospital de Agudos Juan A. Fern\u00e1ndez , Av. Cervi\u00f1o 3356, CP: 1425AGP, Ciudad Autonoma de Buenos Aires ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6177-7894","authenticated-orcid":false,"given":"Nicolas","family":"Atama\u00f1uk","sequence":"additional","affiliation":[{"name":"Hospital de Agudos Juan A. Fern\u00e1ndez , Av. Cervi\u00f1o 3356, CP: 1425AGP, Ciudad Autonoma de Buenos Aires ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"2026011611370776900_ytaf671-B1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.echo.2022.03.012","article-title":"Recommendations for multimodality cardiovascular imaging of patients with hypertrophic cardiomyopathy: an update from the American Society Of Echocardiography, in collaboration with the American Society of Nuclear Cardiology, the society for cardiovascular magnetic resonance, and the society of cardiovascular computed tomography","volume":"35","author":"Nagueh","year":"2022","journal-title":"J Am Soc Echocardiogr"},{"key":"2026011611370776900_ytaf671-B2","first-page":"e558","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"142","author":"Ommen","year":"2020","journal-title":"Circulation"},{"key":"2026011611370776900_ytaf671-B3","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jacc.2015.01.019","article-title":"New perspectives on the prevalence of hypertrophic cardiomyopathy","volume":"65","author":"Semsarian","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2026011611370776900_ytaf671-B4","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1161\/CIRCRESAHA.121.318346","article-title":"Molecular genetic basis of hypertrophic cardiomyopathy","volume":"128","author":"Marian","year":"2021","journal-title":"Circ Res"},{"key":"2026011611370776900_ytaf671-B5","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1093\/eurheartj\/eht439","article-title":"A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM risk-SCD)","volume":"35","author":"Omahony","year":"2014","journal-title":"Eur Heart J"},{"key":"2026011611370776900_ytaf671-B6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jacc.2021.11.021","article-title":"Management of hypertrophic cardiomyopathy: JACC state-of-the-art review","volume":"79","author":"Maron","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2026011611370776900_ytaf671-B7","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1080\/17461391.2019.1587522","article-title":"Indirect clinical markers for the detection of anabolic steroid abuse beyond the conventional doping control in athletes","volume":"19","author":"Christou","year":"2019","journal-title":"Eur J Sport Sci"},{"key":"2026011611370776900_ytaf671-B8","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1161\/CIRCGEN.120.002929","article-title":"Spatial and functional distribution of MYBPC3 pathogenic variants and clinical outcomes in patients with hypertrophic cardiomyopathy","volume":"13","author":"Helms","year":"2020","journal-title":"Circ Genom Precis Med"},{"key":"2026011611370776900_ytaf671-B9","author":"Bennett"},{"key":"2026011611370776900_ytaf671-B10","doi-asserted-by":"crossref","article-title":"The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction.","author":"Kim","DOI":"10.1056\/NEJM200011163432003"},{"key":"2026011611370776900_ytaf671-B11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jacc.2018.05.060","article-title":"Late gadolinium enhancement in patients with hypertrophic cardiomyopathy and preserved systolic function","volume":"72","author":"Mentias","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2026011611370776900_ytaf671-B12","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.accreview.2003.10.024","article-title":"Non-sustained ventricular tachycardia in hypertrophic cardiomyopathy: an independent marker of sudden death risk in young patients","volume":"13","author":"Monserrat","year":"2004","journal-title":"ACC Curr J Rev"},{"key":"2026011611370776900_ytaf671-B13","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC guidelines for the management of cardiomyopathies","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"key":"2026011611370776900_ytaf671-B14","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jacc.2022.07.013","article-title":"Athletic activity for patients with hypertrophic cardiomyopathy and other inherited cardiovascular diseases: JACC focus seminar 3\/4","volume":"80","author":"Mph","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2026011611370776900_ytaf671-B15","doi-asserted-by":"crossref","first-page":"e001666","DOI":"10.1161\/CIRCGENETICS.116.001666","article-title":"Multiple gene variants in hypertrophic cardiomyopathy in the era of next-generation sequencing","volume":"10","author":"Burns","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"key":"2026011611370776900_ytaf671-B16","doi-asserted-by":"crossref","first-page":"e001685","DOI":"10.1161\/CIRCGENETICS.116.001685","article-title":"Prevalence and clinical implication of double mutations in hypertrophic cardiomyopathy: revisiting the gene-dose effect: revisiting the gene-dose effect","volume":"10","author":"Fourey","year":"2017","journal-title":"Circ Cardiovasc Genet"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytaf671\/66114050\/ytaf671.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/1\/ytaf671\/66114050\/ytaf671.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/1\/ytaf671\/66114050\/ytaf671.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T16:37:12Z","timestamp":1768581432000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytaf671\/8402352"}},"subtitle":[],"editor":[{"given":"Danny","family":"van de Sande","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Georgios A","family":"Christou","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Andreea Sorina","family":"Afana","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Mohammed Majid","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Deepti","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytaf671","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,12,23]]},"article-number":"ytaf671"}}