{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:24:50Z","timestamp":1770823490972,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peripartum cardiomyopathy (PPCM) is a rare but life-threatening form of heart failure that typically occurs in late pregnancy or early postpartum. Management of PPCM may be challenging due to hypotension and the unfavorable effect of medication on foetus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A 26-year-old woman with a twin pregnancy was referred at 10 weeks of gestation for evaluation of premature ventricular contractions. Echocardiography revealed left ventricular ejection fraction (LVEF) of 70%, and NT-proBNP level was 75\u2005pg\/mL on blood testing. She was hospitalized at 30 weeks of gestation for threatened preterm labor and diagnosed as pre-eclampsia. At that time, LVEF decreased to 40%, and NT-proBNP level increased to 4359\u2005pg\/mL, prompting an urgent cesarean section. After delivery, heart failure therapy with carvedilol, spironolactone, and furosemide was initiated, but carvedilol was discontinued due to hypotension. On postpartum day 39, she was readmitted with worsening dyspnea. Breastfeeding was ceased. Although bisoprolol and empagliflozin were initiated, LVEF further dropped to 27%. She was discharged with NYHA functional class III. Because LVEF remained impaired despite ongoing heart failure therapy, sacubitril\/valsartan was initiated on postpartum day 122. Subsequently, LVEF improved to 60%, and NT-proBNP decreased to 569\u2005pg\/mL. The patient became asymptomatic and tolerated therapy well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case highlights the complexity of PPCM management. Sacubitril\/valsartan may serve as an effective therapeutic option for PPCM patients who are intolerant to conventional therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag037","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:57:23Z","timestamp":1769086643000},"source":"Crossref","is-referenced-by-count":0,"title":["Sacubitril\/valsartan facilitates recovery of cardiac function in a patient with peripartum cardiomyopathy: a case report"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1621-0200","authenticated-orcid":false,"given":"Yoshihito","family":"Saijo","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital , 2-50-1 Kuramoto-cho, Tokushima 7708503 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotsugu","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital , 2-50-1 Kuramoto-cho, Tokushima 7708503 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusuke","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital , 2-50-1 Kuramoto-cho, Tokushima 7708503 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tokushima University Hospital , 2-50-1 Kuramoto-cho, Tokushima 7708503 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Sata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital , 2-50-1 Kuramoto-cho, Tokushima 7708503 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"2026021109570002500_ytag037-B1","volume-title":"Peripartum Cardiomyopathy, StatPearls Treasure Island (FL) with Ineligible Companies:","author":"Rodriguez Ziccardi"},{"key":"2026021109570002500_ytag037-B2","first-page":"100530","article-title":"Diagnosis and management of peripartum cardiomyopathy and recurrence risk","volume":"17","author":"Iannaccone","year":"2024","journal-title":"Int J Cardiol Congenit Heart Dis"},{"key":"2026021109570002500_ytag037-B3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jacc.2019.11.014","article-title":"Peripartum cardiomyopathy: JACC state-of-the-art review","volume":"75","author":"Davis","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2026021109570002500_ytag037-B4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1536\/ihj.18-729","article-title":"Worldwide incidence of peripartum cardiomyopathy and overall maternal mortality","volume":"60","author":"Isogai","year":"2019","journal-title":"Int Heart J"},{"key":"2026021109570002500_ytag037-B5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/HCO.0000000000001037","article-title":"Peripartum cardiomyopathy: risk factors and predictors of outcome","volume":"38","author":"Viljoen","year":"2023","journal-title":"Curr Opin Cardiol"},{"key":"2026021109570002500_ytag037-B6","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/eurjhf\/hfq120","article-title":"Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on Peripartum Cardiomyopathy","volume":"12","author":"Sliwa","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"2026021109570002500_ytag037-B7","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/ejhf.3618","article-title":"Clinical management and therapeutic optimization of patients with heart failure with reduced ejection fraction and low blood pressure. A clinical consensus statement of the Heart Failure Association (HFA) of the ESC","volume":"27","author":"Skouri","year":"2025","journal-title":"Eur J Heart Fail"},{"key":"2026021109570002500_ytag037-B8","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1093\/eurheartj\/ehad195","article-title":"2023 focused update of the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"44","author":"McDonagh","year":"2023","journal-title":"Eur Heart J"},{"key":"2026021109570002500_ytag037-B9","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N Engl J Med"},{"key":"2026021109570002500_ytag037-B10","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1093\/eurheartj\/ehaf193","article-title":"2025 ESC guidelines for the management of cardiovascular disease and pregnancy","volume":"46","author":"De Backer","year":"2025","journal-title":"Eur Heart J"},{"key":"2026021109570002500_ytag037-B11","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1002\/ehf2.13963","article-title":"Angiotensin receptor-neprilysin inhibitor in symptomatic patients with Duchenne dilated cardiomyopathy: a primetime","volume":"9","author":"Arcudi","year":"2022","journal-title":"ESC Heart Fail"},{"key":"2026021109570002500_ytag037-B12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jacbts.2022.05.010","article-title":"Neprilysin inhibitors in heart failure: the science, mechanism of action, clinical studies, and unanswered questions","volume":"8","author":"Bozkurt","year":"2023","journal-title":"JACC Basic Transl Sci"},{"key":"2026021109570002500_ytag037-B13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijgo.2008.09.017","article-title":"Recovery from severe heart failure following peripartum cardiomyopathy","volume":"104","author":"Fett","year":"2009","journal-title":"Int J Gynaecol Obstet"},{"key":"2026021109570002500_ytag037-B14","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.jacc.2015.06.1309","article-title":"Clinical outcomes for peripartum cardiomyopathy in North America: results of the IPAC study (Investigations of Pregnancy-Associated Cardiomyopathy)","volume":"66","author":"McNamara","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2026021109570002500_ytag037-B15","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1093\/eurheartj\/ehad888","article-title":"A novel score to predict left ventricular recovery in peripartum cardiomyopathy derived from the ESC EORP peripartum cardiomyopathy registry","volume":"45","author":"Jackson","year":"2024","journal-title":"Eur Heart J"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytag037\/66564243\/ytag037.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/2\/ytag037\/66564243\/ytag037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/2\/ytag037\/66564243\/ytag037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:57:09Z","timestamp":1770821829000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytag037\/8440075"}},"subtitle":[],"editor":[{"given":"Giulia Elena","family":"Mandoli","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Matteo","family":"Arzenton","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Reshma","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Deepti","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1,24]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytag037","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,1,24]]},"article-number":"ytag037"}}