{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:24:58Z","timestamp":1780068298488,"version":"3.54.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The long-term vascular response to paclitaxel-eluting stents (PESs) in infrapopliteal (IP) lesions remains histologically uncharacterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A 78-year-old woman with chronic limb-threatening ischaemia underwent implantation of two overlapping paclitaxel-eluting stents from the tibioperoneal trunk to the peroneal artery for an ischaemic ulcer. Multimodality follow-up imaging was obtained at both 3 and 5 years, including optical frequency domain imaging (OFDI) and angioscopy performed immediately before amputation. At 3 years, OFDI and angioscopy demonstrated uncovered struts with adherent thrombus. At 5 years, OFDI and angioscopy showed mature neointima over the proximal and distal segments but persistent fibrin-coated, uncovered struts within the 40-mm overlap. Progressive ischaemia culminated in below-the-knee amputation, permitting stent explantation. Histopathology confirmed proteoglycan-rich neointima at the non-overlapped segments and delayed healing with fibrin deposition and uncovered struts confined to the overlap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 5-year histological evaluation of the PES revealed paclitaxel-related impaired endothelialization in IP lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag061","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T10:16:53Z","timestamp":1769422613000},"source":"Crossref","is-referenced-by-count":1,"title":["Five-year histological evaluation of paclitaxel-eluting stent for an infrapopliteal lesion: a case report"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-3502","authenticated-orcid":false,"given":"Yosuke","family":"Hata","sequence":"first","affiliation":[{"name":"Cardiovascular Center, Kansai Rosai Hospital , Hyogo, 660-8511 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Iida","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Osaka Keisatsu Hospital , Osaka, 543-0042 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Torii","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokai University School of Medicine , Kanagawa, 259-1193 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Shiozaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokai University School of Medicine , Kanagawa, 259-1193 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