{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T19:38:21Z","timestamp":1772653101534,"version":"3.50.1"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Culture-negative infective endocarditis presents significant diagnostic and therapeutic challenges, especially in patients with systemic embolic complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A middle-aged man with a history of intravenous drug use presented with fever, new apical systolic murmur, and widespread embolic phenomena affecting the brain, spleen, kidneys, and lower limb. Transthoracic echocardiography revealed a large posterior mitral leaflet vegetation with moderate\u2013severe mitral regurgitation. Blood and tissue cultures were negative. Next-generation sequencing (NGS) of an aspirated calf muscle abscess identified Rothia dentocariosa. Despite prolonged antimicrobial therapy and multidisciplinary care, persistent vegetations and high embolic risk prompted mitral valve replacement after interval stabilization of intracranial haemorrhages. He recovered without recurrent emboli and with stable prosthetic valve function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Advanced molecular diagnostics such as NGS can be crucial for identifying pathogens in culture-negative endocarditis.<\/jats:p>\n                    <jats:p>Multidisciplinary collaboration and individualized surgical timing are important for achieving optimal outcomes in complex cases with neurological complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag097","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:31:27Z","timestamp":1770121887000},"source":"Crossref","is-referenced-by-count":0,"title":["Case report of extensive embolic complications in culture-negative mitral valve endocarditis due to\n                    <i>Rothia dentocariosa<\/i>"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8984-646X","authenticated-orcid":false,"given":"Hing Yin Wilson","family":"Lam","sequence":"first","affiliation":[{"name":"Department of Medicine, Yan Chai Hospital , 7\u201311 Yan Chai Street, Tsuen Wan, New Territories ,","place":["Hong Kong"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"2026030413312985000_ytag097-B1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2147\/IJGM.S393329","article-title":"Blood culture negative endocarditis: a review of laboratory diagnostic approaches","volume":"16","author":"Lin","year":"2023","journal-title":"Int J Gen Med"},{"key":"2026030413312985000_ytag097-B2","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad193","article-title":"ESC Guidelines for the management of endocarditis: Developed by the task force on the management of endocarditis of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM)","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur Heart J"},{"key":"2026030413312985000_ytag097-B3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/20009666.2021.1880539","article-title":"A rare report of Rothia dentocariosa endocarditis","volume":"11","author":"Elkattawy","year":"2021","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"2026030413312985000_ytag097-B4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.medmal.2020.10.021","article-title":"Rothia spp. Infective endocarditis: a systematic literature review","volume":"51","author":"Franconieri","year":"2021","journal-title":"Infect Dis Now"},{"key":"2026030413312985000_ytag097-B5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/MAJ.0000000000000539","article-title":"Rothia dentocariosa: a rare cause of left-sided endocarditis in an intravenous drug user","volume":"350","author":"Chowdhary","year":"2015","journal-title":"Am J Med Sci"},{"key":"2026030413312985000_ytag097-B6","first-page":"102283","article-title":"Percutaneous mechanical aspiration for infective endocarditis: proceedings from an inaugural multidisciplinary summit and comprehensive review","volume":"3","author":"Marinacci","year":"2024","journal-title":"J Soc Cardiovasc Angiogr Interv"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytag097\/66799459\/ytag097.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/3\/ytag097\/66799459\/ytag097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/3\/ytag097\/66799459\/ytag097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:31:38Z","timestamp":1772649098000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytag097\/8466403"}},"subtitle":[],"editor":[{"given":"Annagrazia","family":"Cecere","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Nisha","family":"Mistry","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Vasilios","family":"Giampatzis","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Deepti","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytag097","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,2,6]]},"article-number":"ytag097"}}