{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:19:14Z","timestamp":1782775154497,"version":"3.54.5"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health with \u2018Current Research funds\u2019.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sodium\u2013glucose cotransporter 2 inhibitors (SGLT-2i) have proven benefits in patients with biventricular heart failure; however, their role in patients with univentricular physiology and failing Fontan circulation (FC) remains largely unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Presentation<\/jats:title>\n                    <jats:p>A 21-year-old male with failing FC, preserved ejection fraction, and protein-loosing enteropathy (PLE) presented to our Adult Congenital Heart Disease Unit for evaluation. Born with a L-transposition of the great vessels with an interventricular septal defect and antero-superior rudimentary chamber, he underwent a Fontan completion at age 5. Since he was 16 years old, he had multiple admissions for FC failure complicated by PLE and ascites, which did not respond to conventional treatments including diuretics, corticosteroids, albumin, and immunoglobulin infusions. Despite the stenosis of the extracardiac conduit, treated by the placement of a covered stent and a further conduit balloon dilation and stenting in a stent procedure performed after 3 years, the patient continued to experience ascites and hypoalbuminemia. To better understand the extent of his lymphatic dysfunction, magnetic resonance lymphoscintigraphy was performed. The study showed significant lymphatic congestion, with leakage into the duodenal lumen and prominent stasis in the thoracic duct. Based on these findings, therapy with SGLT-2i was initiated. Over the following 18 months, there was marked clinical improvement with a reduction in ascites and stabilization of serum protein and albumin levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case highlights the potential benefit of SGLT-2i in managing Fontan failure complicated by PLE. Multicenter studies are needed to further investigate the efficacy, safety, and mechanism of action of SGLT-2i in this unique patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag117","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:19:10Z","timestamp":1771244350000},"source":"Crossref","is-referenced-by-count":1,"title":["Clinical improvement of protein-losing enteropathy after SGLT2 inhibitor therapy in an adult with failing Fontan circulation: a case report"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6257-5913","authenticated-orcid":false,"given":"Emanuela C","family":"D\u2019Angelo","sequence":"first","affiliation":[{"name":"Adult Congenital Heart Disease Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS , Piazza di Sant'Onofrio, 4, 00165 Roma RM ,","place":["Italy"]},{"name":"Guy's and St Thomas' NHS Foundation Trust , Westminster Bridge Road, London SE1 7EH ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Bordonaro","sequence":"additional","affiliation":[{"name":"Advanced Cardiothoracovascular and Fetal Imaging Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS , Piazza di Sant'Onofrio, 4, 00165 Roma RM ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalinda","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS , Piazza di Sant'Onofrio, 4, 00165 Roma RM ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micol","family":"Rebonato","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS , Piazza di Sant'Onofrio, 4, 00165 Roma RM 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