{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T10:55:44Z","timestamp":1776682544182,"version":"3.51.2"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Light-chain amyloidosis (AL) is a rare plasma cell disorder characterized by extracellular deposition of misfolded light chains in multiple organs, typically manifesting with non-specific symptoms that result in delayed diagnosis. Cardiac involvement is a major adverse prognostic factor. The incidence peaks around the age of 65, and occurrence in younger individuals is exceptionally rare, further complicating timely recognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>We report a 41-year-old female patient who exhibited a 1-year course of progressive heart failure, ultimately diagnosed as AL amyloidosis. The \u2018red flags\u2019 were either overlooked or misattributed to other causes of left ventricular hypertrophy, including hypertrophic cardiomyopathy and Fabry disease, partly due to the patient\u2019s atypically young age and family history. The initial suspicion of cardiac amyloidosis was based on advanced cardiac magnetic resonance imaging, which was not immediately available at the time. The initial tissue biopsy result was negative, necessitating an expert re-evaluation with a polarized light microscopy. Laboratory workup for AL amyloidosis revealed non-IgM monoclonal gammopathy of undetermined significance as a preceded plasma cell disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The diagnosis of AL amyloidosis requires evidence of plasma cell dyscrasia through serum\/urine immunochemistry, in addition to the detection and typing of amyloid in tissues. Given the rapid progression of the disease and the poor outcomes observed in the absence of timely targeted therapy, broader laboratory screening for AL amyloidosis should be considered in patients with unexplained hypertrophic phenotype or heart failure, irrespective of age. The improved access to expert multidisciplinary teams through dedicated cardiomyopathy centres is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag231","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:49:02Z","timestamp":1773838142000},"source":"Crossref","is-referenced-by-count":0,"title":["Rare case of young cardiac amyloidosis: difficult diagnostic pathway in routine clinical care"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2373-1183","authenticated-orcid":false,"given":"Olga S","family":"Chumakova","sequence":"first","affiliation":[{"name":"Department of Cardiology, Moscow Municipal Clinical Hospital #17 , Volynskaya street, 7, Moscow 119620 ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-1490","authenticated-orcid":false,"given":"Elena N","family":"Dankovtseva","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Moscow Municipal Clinical Hospital #29 Named After N. E. Bauman , Hospital squire, 2, Moscow 111020 ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4363-8266","authenticated-orcid":false,"given":"Maria A","family":"Sannikova","sequence":"additional","affiliation":[{"name":"Department of Hematology, Botkin Hospital , 2nd Botkinsky Proezd, 5, Moscow 125284 ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1266-4926","authenticated-orcid":false,"given":"Elena A","family":"Mershina","sequence":"additional","affiliation":[{"name":"Medical Research and Education Center, Moscow State University Named After M.V. Lomonsov , Lomonosovsky Prospect, 2, Moscow 119991 ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7795-9709","authenticated-orcid":false,"given":"Svetlana A","family":"Alexandrova","sequence":"additional","affiliation":[{"name":"Radiology Department, Bakulev National Medical Research Center for Cardiovascular Surgery , Rublevskoe highway 135, Moscow 121552 ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7760-5858","authenticated-orcid":false,"given":"Elena A","family":"Stepanova","sequence":"additional","affiliation":[{"name":"Department of Pathology, Russian Medical Academy of Continuous Professional Education , Barrikadnaya street, 2\/1, Moscow 125993 ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-4310","authenticated-orcid":false,"given":"Mariya Y","family":"Suvorina","sequence":"additional","affiliation":[{"name":"Russian Academy of Sciences, Institute of Protein Research , Institutskaya street, 4, Pushchino, Moscow region 142290 ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7065-2045","authenticated-orcid":false,"given":"Dmitry A","family":"Zateyshchikov","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Moscow Municipal Clinical Hospital #29 Named After N. 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