{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T13:09:47Z","timestamp":1779455387004,"version":"3.53.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac involvement is the main determinant of prognosis in immunoglobulin light-chain (AL) amyloidosis, but may be under-recognized in patients with multiple myeloma (MM), particularly when classic electrocardiographic or cardiac magnetic resonance features are absent. Early recognition therefore relies on integration of cardiac biomarkers and multimodality imaging when tissue biopsy or scintigraphic subtyping is impractical.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A 74-year-old man with immunoglobulin A lambda MM and immune thrombocytopenic purpura developed progressive heart failure with preserved ejection fraction (HFpEF), increased left ventricular (LV) wall thickness, and markedly elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP; 7164\u2005pg\/mL). Serial electrocardiograms did not demonstrate classic low voltage. Cardiac magnetic resonance revealed diffuse non-ischaemic late gadolinium enhancement consistent with an infiltrative cardiomyopathy. Bone-avid scintigraphy was non-contributory in the context of MM. A working diagnosis of highly likely AL cardiac amyloidosis was established. Clone-directed therapy (two cycles of bortezomib-cyclophosphamide-dexamethasone followed by three ongoing cycles of carfilzomib-lenalidomide-dexamethasone), together with volume-guided heart failure management, resulted in biochemical improvement (NT-proBNP 3431\u2005pg\/mL), although structural cardiac abnormalities persisted on follow-up imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights real-world diagnostic and management challenges of AL cardiac amyloidosis in MM, particularly when electrocardiography and scintigraphy are equivocal, underscoring the importance of early suspicion, multimodality imaging, and close cardio-haematologic collaboration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case illustrates real-world diagnostic challenges of AL cardiac amyloidosis (AL-CA) in MM when electrocardiography (ECG) and scintigraphy are equivocal. Clinicians should suspect AL-CA when HFpEF coexists with LV thickening and abnormal LA burden. Management emphasizes euvolaemia, cautious afterload reduction, and early haematology\u2013cardiology co-management<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag288","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:03:11Z","timestamp":1778144591000},"source":"Crossref","is-referenced-by-count":0,"title":["Immunoglobulin A lambda multiple myeloma\u2013 related light-chain cardiac amyloidosis presenting with progressive heart failure with preserved ejection fraction: a multimodality imaging case report"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3391-8366","authenticated-orcid":false,"given":"Jie","family":"He","sequence":"first","affiliation":[{"name":"Cardiovascular Medicine Department, Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital , Nanchong, 637000, Sichuan 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