{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:18:44Z","timestamp":1778617124711,"version":"3.51.4"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"U. N. Mehta Institute of Cardiology and Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Loeffler\u2019s endocarditis is a serious manifestation of hypereosinophilia, and it is associated with endomyocardial fibrosis, thrombus formation, valvular dysfunction, and, rarely, intracardiac mass lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A 28-year-old male patient had progressive dyspnoea, facial oedema, and fatigue for 2 years. A 2D trans-thoracic echocardiogram revealed a 24 \u00d7 15\u2005mm mobile echogenic mass attached to the mitral valve, associated with severe mitral regurgitation. Blood counts showed hypereosinophilia. Cardiac MRI showed subendocardial fibrosis. Bone marrow examination showed increased hypercellularity, and molecular testing was positive for FIP1L1\u2013PDGFRA fusion, confirming a myeloid neoplasm with hypereosinophilia. The patient was treated with corticosteroids, anticoagulation, and Imatinib. Following initiation of therapy, the mass size reduced, and the patient improved symptomatically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case emphasizes the importance of a thorough diagnostic workup, including genetic testing in Loeffler\u2019s Syndrome, to guide therapy. Recognizing molecularly driven eosinophilic disorders is essential, as targeted treatment can significantly improve prognosis. The presence of the Fip1-Like1-platelet-derived growth factor receptor alpha (FIP1L1\u2013PDGFR\u03b1) fusion gene is a rare cause of hypereosinophilic syndrome requiring a distinct therapeutic approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag296","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:43:47Z","timestamp":1778154227000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypereosinophilic endocarditis presenting with intracardiac mass and severe mitral regurgitation: a case report of FIP1L1\u2013PDGFRA positive myeloid neoplasm"],"prefix":"10.1093","volume":"10","author":[{"given":"Nilay Sanjay","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Cardiology, U. N. Mehta Institute of Cardiology and Research Centre (UNMICRC), Civil Hospital Campus , Asarwa, Ahmedabad, Gujarat 380016 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhrajyoti","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, U. N. Mehta Institute of Cardiology and Research Centre (UNMICRC), Civil Hospital Campus , Asarwa, Ahmedabad, Gujarat 380016 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam S","family":"Kothari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, U. N. Mehta Institute of Cardiology and Research Centre (UNMICRC), Civil Hospital Campus , Asarwa, Ahmedabad, Gujarat 380016 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, U. N. Mehta Institute of Cardiology and Research Centre (UNMICRC), Civil Hospital Campus , Asarwa, Ahmedabad, Gujarat 380016 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8228-7740","authenticated-orcid":false,"given":"Kewal","family":"Kanabar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, U. N. Mehta Institute of Cardiology and Research Centre (UNMICRC), Civil Hospital Campus , Asarwa, Ahmedabad, Gujarat 380016 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"2026051215423032900_ytag296-B1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/heartjnl-2015-307959","article-title":"Hypereosinophilic syndrome: cardiac diagnosis and management","volume":"102","author":"Mankad","year":"2016","journal-title":"Heart"},{"key":"2026051215423032900_ytag296-B2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ajh.26352","article-title":"World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management","volume":"97","author":"Shomali","year":"2022","journal-title":"Am J Hematol"},{"key":"2026051215423032900_ytag296-B3","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/MD.0b013e3182a71eba","article-title":"The Spectrum of FIP1L1-PDGFRA-associated chronic Eosinophilic Leukaemia: new insights based on a survey of 44 cases","volume":"92","author":"Legrand","year":"2013","journal-title":"Medicine (Baltimore)"},{"key":"2026051215423032900_ytag296-B4","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/ajh.25945","article-title":"Epidemiology, clinical picture and long-term outcomes of FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia: data from 151 patients","volume":"95","author":"Rohmer","year":"2020","journal-title":"Am J Hematol"},{"key":"2026051215423032900_ytag296-B5","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1182\/blood-2003-06-1824","article-title":"The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management","volume":"103","author":"Gotlib","year":"2004","journal-title":"Blood"},{"key":"2026051215423032900_ytag296-B6","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.athoracsur.2011.08.062","article-title":"Unusual cause of acute mitral regurgitation: idiopathic hypereosinophilic syndrome","volume":"93","author":"Madhwal","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"2026051215423032900_ytag296-B7","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1056\/NEJMoa025217","article-title":"A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome","volume":"348","author":"Cools","year":"2003","journal-title":"N Engl J Med"},{"key":"2026051215423032900_ytag296-B8","doi-asserted-by":"crossref","first-page":"33229","DOI":"10.18632\/oncotarget.8906","article-title":"Long-term outcomes of imatinib in patients with FIP1L1\/PDGFRA associated chronic eosinophilic leukemia: experience of a single center in China","volume":"7","author":"Qu","year":"2016","journal-title":"Oncotarget"},{"key":"2026051215423032900_ytag296-B9","first-page":"108","article-title":"Severe mitral regurgitation caused by eosinophilic endocarditis","volume":"10","author":"Van Dongen","year":"2014","journal-title":"J Cardiol Cases"},{"key":"2026051215423032900_ytag296-B10","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.jacc.2018.01.017","article-title":"Spectrum of restrictive and infiltrative cardiomyopathies: part 2 of a 2-part series","volume":"71","author":"Pereira","year":"2018","journal-title":"J Am Coll Cardiol"}],"container-title":["European Heart Journal - 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