{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:57:09Z","timestamp":1784602629551,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Associazione Il Cuore di Andrea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disorder characterized by adrenergically mediated ventricular arrhythmias occurring in structurally normal hearts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A young asymptomatic female competitive football player with a structurally normal heart developed progressively complex exercise-induced ventricular arrhythmias over several years, leading to the diagnosis of CPVT confirmed by identification of a novel pathogenic RYR2 variant through familial cosegregation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case illustrates how CPVT may present with a subtle and fluctuating phenotype, remaining concealed for years despite regular cardiovascular screening in athletes. Serial exercise-based testing was crucial to unmask the arrhythmic substrate when resting investigations and family history were initially unremarkable. Comprehensive family evaluation enabled reclassification of a novel RYR2 variant, emphasizing the importance of integrating clinical and genetic data in inherited arrhythmia syndromes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag377","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:40:20Z","timestamp":1779190820000},"source":"Crossref","is-referenced-by-count":1,"title":["Progressively complex exercise-induced ventricular arrhythmias unveiling catecholaminergic polymorphic ventricular tachycardia associated with a novel RYR2 variant in a competitive athlete: a case report"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2395-4977","authenticated-orcid":false,"given":"Marco","family":"Vecchiato","sequence":"first","affiliation":[{"name":"Sports and Exercise Medicine Division, Department of Medicine, University of Padova , Via Giustiniani 2, Padova 35128 ,","place":["Italy"]},{"name":"Sports Medicine and Cardiovascular Rehabilitation Unit, ULSS3 , Piazzale della Bastia 3, Noale, Venezia 30033 ,","place":["Italy"]},{"name":"Department of Theoretical and Applied Sciences, eCampus University , Via Isimbardi 10, Novedrate, Como 22060 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3578-0583","authenticated-orcid":false,"given":"Alessandro","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, Padova 35128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3646-0669","authenticated-orcid":false,"given":"Kalliopi","family":"Pilichou","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padova , Via Giustiniani 2, Padova 35128 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pescatore","sequence":"additional","affiliation":[{"name":"Sports Medicine and Cardiovascular Rehabilitation Unit, ULSS3 , Piazzale della Bastia 3, Noale, Venezia 30033 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Brugin","sequence":"additional","affiliation":[{"name":"Sports Medicine and Cardiovascular Rehabilitation Unit, ULSS3 , Piazzale della Bastia 3, Noale, Venezia 30033 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"2026061210513400100_ytag377-B1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pcad.2007.10.005","article-title":"Catecholaminergic polymorphic ventricular tachycardia","volume":"51","author":"Liu","year":"2008","journal-title":"Prog Cardiovasc Dis"},{"key":"2026061210513400100_ytag377-B2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fcvm.2019.00092","article-title":"CPVT: arrhythmogenesis, therapeutic management, and future perspectives. 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