{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:53:32Z","timestamp":1781895212313,"version":"3.54.5"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malignant pericardial effusion is a life-threatening manifestation of advanced non-small-cell lung cancer (NSCLC). Cardiac tamponade as an initial presentation is uncommon, and coexistent pathologies can complicate diagnosis and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A 72-year-old man with mild chronic obstructive pulmonary disease (COPD) and a remote 2-pack-year smoking history was admitted with COVID-19 infection and possible superimposed pneumonia. Initial imaging revealed pericardial inflammation and a small effusion, raising concern for pericarditis. Subsequent echocardiography demonstrated a large pericardial effusion with tamponade physiology requiring pericardiocentesis, while cardiac magnetic resonance and computed tomography suggested possible malignancy. Cytology from pericardial and pleural fluid confirmed adenocarcinoma and bronchoscopy established stage IV epidermal growth factor\u2013mutant NSCLC with cerebellar metastases. The patient experienced recurrent malignant effusions, managed successfully with balloon pericardiotomy and was treated with Osimertinib, resulting in sustained remission of effusions and clinical recovery. Careful review of multimodality imaging also revealed partial anomalous pulmonary venous return with significant left-to-right shunting, which may have exerted a protective hemodynamic effect on tamponade physiology. This may suggest a potential, though speculative, contribution of the anomalous pulmonary venous return to the observed tamponade physiology. At 2-year follow-up, the patient remains clinically and hemodynamically stable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case illustrates the interesting duality of how multiple concurrent pathologies\u2014including COVID-19 pneumonia, pericarditis, malignant pleuro-pericardial effusions, metastatic lung adenocarcinoma, and PAPVR\u2014can coexist and probably shape the clinical course. The case underscores the indispensable role of multimodality imaging, molecular profiling, and minimally invasive pericardial interventions in guiding diagnosis, therapy, and prognosis in complex cardio-oncology presentations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag396","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T03:41:05Z","timestamp":1779853265000},"source":"Crossref","is-referenced-by-count":0,"title":["Case reports of a double threat: when cancer and hidden congenital heart defects collide: malignant tamponade unveils a hidden pulmonary venous anomaly"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8502-5382","authenticated-orcid":false,"given":"Alexis Phyllip","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Specialty Medicine Department, Cardiology Section, Bruce W. Carter, VA Healthcare System Department of Veterans Affairs , 1201 NW 16th Street, Miami, FL 33125 ,","place":["USA"]},{"name":"Innovation Health Services , 801 Southampton Ave., Suite A, Norfolk, VA 23510 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4065-6596","authenticated-orcid":false,"given":"Sonia I","family":"Vicenty-Rivera","sequence":"additional","affiliation":[{"name":"Specialty Medicine Department, Cardiology Section, Bruce W. Carter, VA Healthcare System Department of Veterans Affairs , 1201 NW 16th Street, Miami, FL 33125 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"2026061914124688100_ytag396-B1","first-page":"135","article-title":"Development of pericardial effusion in non-small cell lung cancer is associated with the presence of EGFR\/ALK mutations","volume":"24","author":"Nardi-Agmon","year":"2022","journal-title":"Isr Med Assoc J"},{"key":"2026061914124688100_ytag396-B2","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.4081\/cp.2011.e38","article-title":"Survival post-surgery for malignant pericardial effusion","volume":"1","author":"Nguyen","year":"2011","journal-title":"Clin Pract"},{"key":"2026061914124688100_ytag396-B3","doi-asserted-by":"crossref","first-page":"A4415","DOI":"10.1016\/j.chest.2023.07.2869","article-title":"Cardiac tamponade as the initial presentation of lung adenocarcinoma","volume":"164","author":"Kunnummal","year":"2023","journal-title":"Chest"},{"key":"2026061914124688100_ytag396-B4","first-page":"e13762","article-title":"Lung adenocarcinoma presenting as malignant pericardial effusion\/tamponade","volume":"13","author":"Vemireddy","year":"2021","journal-title":"Cureus"},{"key":"2026061914124688100_ytag396-B5","first-page":"244","article-title":"Percutaneous balloon pericardial window for patients with malignant pericardial effusion and tamponade","volume":"22","author":"Palacios","year":"1991","journal-title":"Cathet Cardiovasc Diagn"},{"key":"2026061914124688100_ytag396-B6","first-page":"1619","article-title":"Systematic review of percutaneous interventions for malignant pericardial effusion","volume":"101","author":"Virk","year":"2015","journal-title":"Heart (British Cardiac Society)"},{"key":"2026061914124688100_ytag396-B7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jaccao.2019.10.006","article-title":"Osimertinib-induced cardiotoxicity: a retrospective review of the FDA adverse events reporting system (FAERS)","volume":"1","author":"Anand","year":"2019","journal-title":"JACC CardioOncol"},{"key":"2026061914124688100_ytag396-B8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2147\/OTT.S513879","article-title":"A rare histologic transformation from EGFR-positive lung adenocarcinoma to EGFR-negative squamous cell carcinoma after EGFR-TKIs resistance: a case report","volume":"18","author":"Qiu","year":"2025","journal-title":"Onco Targets Ther"},{"key":"2026061914124688100_ytag396-B9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.14423\/SMJ.0000000000000230","article-title":"Protective effect of pulmonary hypertension against right-sided tamponade in pericardial effusion","volume":"108","author":"Khan","year":"2015","journal-title":"South Med J"},{"key":"2026061914124688100_ytag396-B10","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s11739-024-03566-y","article-title":"Is pulmonary hypertension protective against cardiac tamponade? A systematic review","volume":"19","author":"Adrian","year":"2024","journal-title":"Intern Emerg Med"},{"key":"2026061914124688100_ytag396-B11","first-page":"102619","article-title":"Cardiac tamponade in pulmonary hypertension: management using right heart catheterization guidance","volume":"4","author":"Shin","year":"2025","journal-title":"J Soc Cardiovasc Angiogr Interv"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytag396\/68403228\/ytag396.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/6\/ytag396\/68403228\/ytag396.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/6\/ytag396\/68403228\/ytag396.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:12:54Z","timestamp":1781892774000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytag396\/8694937"}},"subtitle":[],"editor":[{"given":"Sarandeep Kaur","family":"Marwaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Alessandro","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Giulia","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Deepti","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytag396","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,5,27]]},"article-number":"ytag396"}}