{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:22:42Z","timestamp":1783167762468,"version":"3.54.6"},"reference-count":3,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Loeffler endocarditis (LE) is a rare but potentially life-threatening cardiac manifestation of hyper-eosinophilic syndrome (HES). The disease is often complicated by intracardiac thrombus formation and may lead to severe restrictive cardiomyopathy and thromboembolic events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report the case of a 71-year-old man with long-standing idiopathic hyper-eosinophilia who presented with chest pain and progressive dyspnoea. Cardiac MRI revealed apical endocardial fibrosis with intracavitary thrombus, confirming a diagnosis of Loeffler endocarditis. The patient was successfully treated with corticosteroids and anticoagulation with vitamin K antagonists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the diagnostic challenges and therapeutic strategies in managing LE. Cardiac MRI is essential for diagnosis, and early initiation of steroids and anticoagulation significantly improves clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag472","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:49:11Z","timestamp":1782992951000},"source":"Crossref","is-referenced-by-count":0,"title":["A hidden threat in the apical shadow: a case report regarding Loeffler endocarditis mimicking NSTEMI"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1328-9876","authenticated-orcid":false,"given":"Carlo Alberto","family":"Caruzzo","sequence":"first","affiliation":[{"name":"Division of Cardiology, Ospedale La Carit\u00e0, Ente Ospedaliero Cantonale , Via dell\u2019Ospedale 1, Locarno 6600 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8726-6244","authenticated-orcid":false,"given":"Elia","family":"Rigamonti","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale , Via Tesserete 48, Lugano 6900 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Romana","family":"Scopigni","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale , Via Tesserete 48, Lugano 6900 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Giulia","family":"Pavon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale , Via Tesserete 48, Lugano 6900 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Facchini","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Ospedale La Carit\u00e0, Ente Ospedaliero Cantonale , Via dell\u2019Ospedale 1, Locarno 6600 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"2026070408104426000_ytag472-B1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1186\/s12872-021-02443-2","article-title":"Loeffler endocarditis with intracardiac thrombus: case report and literature review","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"2026070408104426000_ytag472-B2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.iac.2007.07.001","article-title":"Cardiovascular manifestations of hypereosinophilic syndromes","volume":"27","author":"Ogbogu","year":"2007","journal-title":"Immunol Allergy Clin North Am"},{"key":"2026070408104426000_ytag472-B3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1398-9995.2004.00465.x","article-title":"Recent advances in pathogenesis and management of hypereosinophilic syndromes","volume":"59","author":"Roufosse","year":"2004","journal-title":"Allergy"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/7\/ytag472\/68696429\/ytag472.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/7\/ytag472\/68696429\/ytag472.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:10:47Z","timestamp":1783167047000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytag472\/8724801"}},"subtitle":[],"editor":[{"given":"Golnaz","family":"Houshmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Clement","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Amirafraz Fallah","family":"Najmabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Julian Vega","family":"Adauy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Nelya","family":"Oryshchyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Deepti","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":3,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytag472","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,7]]},"article-number":"ytag472"}}