{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:46:47Z","timestamp":1783540007263,"version":"3.55.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Concomitant mitral regurgitation (MR) and tricuspid regurgitation (TR) are frequently encountered in patients with severe aortic stenosis (AS) and are associated with adverse clinical outcomes after transcatheter aortic valve implantation (TAVI). However, the impact of transcatheter heart valve selection on post-procedural multi-valvular haemodynamics remains incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>An 87-year-old woman with symptomatic low-flow, low-gradient AS complicated by moderate-to-severe MR and severe TR was admitted with refractory heart failure despite intensive medical therapy. Given her advanced age, frailty, and high surgical risk, transfemoral TAVI was performed using a 23-mm Navitor\u2122 Vision valve (Abbott Structural Heart, Santa Clara, CA, USA).<\/jats:p>\n                    <jats:p>Valve selection was guided by the presence of a small aortic annulus and the need to balance optimal haemodynamic performance with minimization of potential mitral valve interaction. The procedure was successfully completed without significant residual transvalvular gradient or paravalvular leakage. Following TAVI, relief of afterload was achieved, leading to improvement in functional MR and TR, with discontinuation of inotropic support. Follow-up echocardiography demonstrated a reduction in both MR and TR, accompanied by a decrease in right ventricular systolic pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We report a case of symptomatic low-flow, low-gradient AS with concomitant MR and TR that was successfully treated with TAVI using a Navitor Vision valve. In patients with small annuli and complex multi-valvular disease, careful transcatheter heart valve selection and procedural optimization may facilitate favourable haemodynamic outcomes and reverse remodelling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag479","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:55:09Z","timestamp":1781870109000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical improvement of functional mitral and tricuspid regurgitation following transcatheter aortic valve implantation with the NAVITOR VISION system: a case report"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6281-5079","authenticated-orcid":false,"given":"Akira","family":"Otani","sequence":"first","affiliation":[{"name":"Department of Cardiology, Yamato Seiwa Hospital , 9-8-2 Minamirinkan, Kanagawa 242-0006 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshi","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yamato Seiwa Hospital , 9-8-2 Minamirinkan, Kanagawa 242-0006 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Doijiri","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yamato Seiwa Hospital , 9-8-2 Minamirinkan, Kanagawa 242-0006 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9886-3992","authenticated-orcid":false,"given":"Minako","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Yamato Seiwa Hospital , 9-8-2 Minamirinkan, Kanagawa 242-0006 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimiko","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Yamato Seiwa Hospital , 9-8-2 Minamirinkan, Kanagawa 242-0006 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"2026070814312281100_ytag479-B1","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1093\/eurheartj\/ehaf194","article-title":"2025 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"46","author":"Praz","year":"2025","journal-title":"Eur Heart J"},{"key":"2026070814312281100_ytag479-B2","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or surgical aortic-valve replacement in intermediate-risk patients","volume":"374","author":"Leon","year":"2016","journal-title":"N Engl J Med"},{"key":"2026070814312281100_ytag479-B3","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.jacc.2014.02.573","article-title":"Significant mitral regurgitation left untreated at the time of aortic valve replacement: a comprehensive review of a frequent entity in the transcatheter aortic valve replacement era","volume":"63","author":"Nombela-Franco","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2026070814312281100_ytag479-B4","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1161\/CIRCULATIONAHA.113.003885","article-title":"Impact of preoperative moderate\/severe mitral regurgitation on 2-year outcome after transcatheter and surgical aortic valve replacement: insight from the placement of aortic transcatheter valve (PARTNER) trial cohort A","volume":"128","author":"Barbanti","year":"2013","journal-title":"Circulation"},{"key":"2026070814312281100_ytag479-B5","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.114.002073","article-title":"Effect of tricuspid regurgitation and the right heart on survival after transcatheter aortic valve replacement: insights from the placement of aortic transcatheter valves II inoperable cohort","volume":"8","author":"Lindman","year":"2015","journal-title":"Circ Cardiovasc Interv"},{"key":"2026070814312281100_ytag479-B6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/heartjnl-2017-311552","article-title":"Mitral regurgitation in patients with severe aortic stenosis: diagnosis and management","volume":"104","author":"Sannino","year":"2018","journal-title":"Heart"},{"key":"2026070814312281100_ytag479-B7","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4244\/EIJ-D-22-01062","article-title":"Impact of mitral regurgitation aetiology on the outcomes of transcatheter aortic valve implantation","volume":"19","author":"Doldi","year":"2023","journal-title":"EuroIntervention"},{"key":"2026070814312281100_ytag479-B8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.echo.2016.11.006","article-title":"Comprehensive right-sided assessment for transcatheter aortic valve replacement risk stratification: time for a change","volume":"30","author":"Cavalcante","year":"2017","journal-title":"J Am Soc Echocardiogr"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytag479\/68570189\/ytag479.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/7\/ytag479\/68570189\/ytag479.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/7\/ytag479\/68570189\/ytag479.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:31:34Z","timestamp":1783535494000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytag479\/8713047"}},"subtitle":[],"editor":[{"given":"Christoph","family":"Sinning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Giulio","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Poonam","family":"Velagapudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Deepti","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":8,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytag479","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,6,22]]},"article-number":"ytag479"}}