{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:18:24Z","timestamp":1787948304968,"version":"build-2784847793"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Renal denervation (RDN) is an emerging therapy for selected patients with resistant hypertension. Its broader autonomic effects may extend beyond blood pressure regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A 57-year-old man with resistant hypertension treated with six antihypertensive drugs and recurrent autonomic and generalized seizures underwent radiofrequency RDN. At 3 months, ambulatory blood pressure monitoring showed sustained improvement (24\u2005h mean 139\/87\u2005mmHg), enabling therapy de-escalation. Generalized tonic\u2013clonic seizures resolved, and autonomic\/focal events markedly decreased without changes in antiepileptic medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case illustrates a potential extrapressor effect of RDN mediated by modulation of sympathetic overactivity. Although causality cannot be drawn from a single case, the parallel neurological improvement supports exploring RDN\u2019s role in conditions involving autonomic dysregulation, including certain epileptic syndromes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag592","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:23:40Z","timestamp":1786361020000},"source":"Crossref","is-referenced-by-count":0,"title":["Resistant hypertension and epileptic seizures: a possible modulatory role of renal denervation\u2014a case report"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5777-6596","authenticated-orcid":false,"given":"Antonio","family":"Bustos-Merlo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Virgen de las Nieves, Avenida de las Fuerzas Armadas , 18014 Granada ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA , 18016 Granada ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Fajardo-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Virgen de las Nieves, Avenida de las Fuerzas Armadas , 18014 Granada ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8344-0199","authenticated-orcid":false,"given":"Teresa","family":"Bretones-Del Pino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Virgen de las Nieves, Avenida de las Fuerzas Armadas , 18014 Granada ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Molina-Navarro","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Virgen de las Nieves, Avenida de las Fuerzas Armadas , 18014 Granada ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Ja\u00e9n-\u00c1guila","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Virgen de las Nieves, Avenida de las Fuerzas Armadas , 18014 Granada ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA , 18016 Granada ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"2026082815464581200_ytag592-B1","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","article-title":"2023 ESH Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension: endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)","volume":"41","author":"Mancia","year":"2023","journal-title":"J Hypertens"},{"key":"2026082815464581200_ytag592-B2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.31083\/j.jin2307128","article-title":"The role of the autonomic nervous system in epilepsy and migraine: a narrative review","volume":"23","author":"D'Agnano","year":"2024","journal-title":"J Integr Neurosci"},{"key":"2026082815464581200_ytag592-B3","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1093\/eurheartj\/ehu093","article-title":"Effect of renal denervation on left ventricular mass and function in patients with resistant hypertension: data from a multi-centre cardiovascular magnetic resonance imaging trial","volume":"35","author":"Mahfoud","year":"2014","journal-title":"Eur Heart J"},{"key":"2026082815464581200_ytag592-B4","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1038\/s41440-024-01755-y","article-title":"Renal denervation for hypertensive heart disease and atrial fibrillation","volume":"47","author":"Shinohara","year":"2024","journal-title":"Hypertens Res"},{"key":"2026082815464581200_ytag592-B5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/ajh\/hpae027","article-title":"Afferent renal denervation attenuates sympathetic overactivation from the paraventricular nucleus in spontaneously hypertensive rats","volume":"37","author":"Li","year":"2024","journal-title":"Am J Hypertens"},{"key":"2026082815464581200_ytag592-B6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s41983-021-00422-0","article-title":"Interictal autonomic dysfunction in patients with epilepsy","volume":"57","author":"Shaker","year":"2021","journal-title":"Egypt J Neurol Psychiatry Neurosurg"},{"key":"2026082815464581200_ytag592-B7","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1161\/HYPERTENSIONAHA.112.201186","article-title":"Catheter-based renal nerve ablation and centrally generated sympathetic activity in difficult-to-control hypertensive patients: prospective case series","volume":"60","author":"Brinkmann","year":"2012","journal-title":"Hypertension"},{"key":"2026082815464581200_ytag592-B8","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/S0140-6736(20)30554-7","article-title":"Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial","volume":"395","author":"B\u00f6hm","year":"2020","journal-title":"Lancet"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytag592\/70610976\/ytag592.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/9\/ytag592\/70610976\/ytag592.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/9\/ytag592\/70610976\/ytag592.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:46:54Z","timestamp":1787946414000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytag592\/8758924"}},"subtitle":[],"editor":[{"given":"David","family":"Oxborough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Jamol","family":"Uzokov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Yuan-Yuan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Azhar Saud","family":"Akhmimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Deepti","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,8,27]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytag592","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,11]]},"article-number":"ytag592"}}