{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:03:13Z","timestamp":1789470193781,"version":"build-2803163510"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key R&D Program of \u2018Jianbing Lingyan+X\u2019 in Zhejiang Province","award":["2026C04038"],"award-info":[{"award-number":["2026C04038"]}]},{"name":"Jie Bang Gua Shuai Project of Wenzhou Science and Technology Bureau","award":["ZY2023022"],"award-info":[{"award-number":["ZY2023022"]}]},{"name":"Jie Bang Gua Shuai Project of Wenzhou Science and Technology Bureau","award":["ZY2024019"],"award-info":[{"award-number":["ZY2024019"]}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation of China","doi-asserted-by":"publisher","award":["LTGY24H180019"],"award-info":[{"award-number":["LTGY24H180019"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical and Health Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY160"],"award-info":[{"award-number":["2024KY160"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter tricuspid valve replacement (TTVR) is an option for selected patients with severe tricuspid regurgitation (TR) who are at high surgical risk, but experience remains limited in those with extreme right-heart anatomy, including a giant right atrium and a markedly enlarged elliptical tricuspid annulus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A 62-year-old man was admitted with progressive dyspnoea and lower-extremity oedema (NYHA class IV). He had previously undergone mechanical mitral valve replacement and transcatheter aortic valve replacement. Echocardiography and computed tomography angiography (CTA) showed torrential TR, a giant right atrium (11.59 \u00d7 7.73\u2005cm), preserved right ventricular systolic function, and a markedly elliptical annulus with a perimeter-derived diameter of 55.5\u2005mm. Persistent TR despite satisfactory left-sided prosthetic valve function prompted transcatheter evaluation. Redo surgery was prohibitive and transcatheter edge-to-edge repair was unsuitable. The Heart Team selected LuX-Valve Plus because its leaflet graspers and septal anchor provide radial force-independent multipoint fixation. A 79.2-mm bend-point-to-annulus distance exceeded the proposed 45\u201370\u2005mm range, requiring a slightly lateral jugular entry angle and complicating depth control and coaxial alignment. The mechanical mitral prosthesis limited visualization by transoesophageal echocardiography (TEE) but served as a fluoroscopic landmark; TEE and fluoroscopy enabled successful implantation. At 1 month, NYHA class improved to II, with stable prosthetic haemodynamics, no obvious transvalvular regurgitation, and trivial paravalvular leak; findings remained stable at 6\u20137 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case highlights the feasibility of transjugular LuX-Valve Plus TTVR in extreme right-heart anatomy and emphasizes the importance of anatomy-driven device selection, tailored delivery and imaging strategies, and individualized postprocedural management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytag658","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:18:54Z","timestamp":1788347934000},"source":"Crossref","is-referenced-by-count":0,"title":["Transjugular LuX-Valve Plus transcatheter tricuspid valve replacement for torrential tricuspid regurgitation in a patient with a giant right atrium and multiple prior valve interventions: a case report"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4646-7777","authenticated-orcid":false,"given":"Quntai","family":"Qiu","sequence":"first","affiliation":[{"name":"Zhejiang-Ireland Joint Laboratory for Precision Diagnosis and Treatment of Valvular Heart Diseases, The Second Affiliated Hospital of Wenzhou Medical University , 1111 East Wenzhou Avenue, Longwan, Wenzhou 325024 ,","place":["China"]},{"name":"Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , 1111 East Wenzhou Avenue, Longwan, Wenzhou 325024 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-8961","authenticated-orcid":false,"given":"Xinlei","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang-Ireland Joint Laboratory for Precision Diagnosis and Treatment of Valvular Heart Diseases, The Second Affiliated Hospital of Wenzhou Medical University , 1111 East Wenzhou Avenue, Longwan, Wenzhou 325024 ,","place":["China"]},{"name":"Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , 1111 East Wenzhou Avenue, Longwan, Wenzhou 325024 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daozhu","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang-Ireland Joint Laboratory for Precision Diagnosis and Treatment of Valvular Heart Diseases, The Second Affiliated Hospital of Wenzhou Medical University , 1111 East Wenzhou Avenue, Longwan, Wenzhou 325024 ,","place":["China"]},{"name":"Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , 1111 East Wenzhou Avenue, Longwan, Wenzhou 325024 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang-Ireland Joint Laboratory for Precision Diagnosis and Treatment of Valvular Heart Diseases, The Second Affiliated Hospital of Wenzhou Medical University , 1111 East Wenzhou Avenue, Longwan, Wenzhou 325024 ,","place":["China"]},{"name":"Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , 1111 East Wenzhou Avenue, Longwan, Wenzhou 325024 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianpin","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang-Ireland Joint Laboratory for Precision Diagnosis and Treatment of Valvular Heart Diseases, The Second Affiliated Hospital of Wenzhou Medical University , 1111 East Wenzhou Avenue, Longwan, Wenzhou 325024 ,","place":["China"]},{"name":"Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , 1111 East Wenzhou Avenue, Longwan, Wenzhou 325024 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"2026091506111303000_ytag658-B1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/eurheartj\/ehy641","article-title":"Tricuspid regurgitation is associated with increased mortality independent of pulmonary pressures and right heart failure: a systematic review and meta-analysis","volume":"40","author":"Wang","year":"2019","journal-title":"Eur Heart J"},{"key":"2026091506111303000_ytag658-B2","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1093\/eurheartj\/ehaf194","article-title":"2025 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"46","author":"Praz","year":"2025","journal-title":"Eur Heart J"},{"key":"2026091506111303000_ytag658-B3","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1016\/j.jcin.2024.09.019","article-title":"Eligibility for transcatheter tricuspid valve interventions in patients with tricuspid regurgitation","volume":"17","author":"Tanaka","year":"2024","journal-title":"JACC Cardiovasc Interv"},{"key":"2026091506111303000_ytag658-B4","first-page":"e44898","article-title":"Giant right atrium: an extreme structural damage case due to rheumatic heart disease","volume":"15","author":"Voltarelli","year":"2023","journal-title":"Cureus"},{"key":"2026091506111303000_ytag658-B5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jacc.2024.10.071","article-title":"Transcatheter tricuspid valve replacement","volume":"85","author":"Hausleiter","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"2026091506111303000_ytag658-B6","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1093\/eurheartj\/ehab679","article-title":"TRI-SCORE: a new risk score for in-hospital mortality prediction after isolated tricuspid valve surgery","volume":"43","author":"Dreyfus","year":"2022","journal-title":"Eur Heart J"},{"key":"2026091506111303000_ytag658-B7","doi-asserted-by":"crossref","first-page":"102699","DOI":"10.1016\/j.jaccas.2024.102699","article-title":"Step-by-step transcatheter tricuspid valve replacement using the LuX-valve plus system","volume":"29","author":"Wong","year":"2024","journal-title":"JACC Case Rep"},{"key":"2026091506111303000_ytag658-B8","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1093\/eurheartj\/ehae165","article-title":"LuX-valve plus transcatheter tricuspid valve replacement for massive tricuspid flail after lead extraction","volume":"45","author":"Bakar","year":"2024","journal-title":"Eur Heart J"},{"key":"2026091506111303000_ytag658-B9","doi-asserted-by":"crossref","first-page":"e1088","DOI":"10.4244\/EIJ-D-22-00517","article-title":"A first-in-human study of transjugular transcatheter tricuspid valve replacement with the LuX-Valve Plus system","volume":"18","author":"Zhang","year":"2023","journal-title":"EuroIntervention"},{"key":"2026091506111303000_ytag658-B10","doi-asserted-by":"crossref","first-page":"100792","DOI":"10.1016\/j.shj.2026.100792","article-title":"State-of-the-art review: transjugular tricuspid valve replacement using the LuX-valve plus system","volume":"10","author":"Donal","year":"2026","journal-title":"Struct Heart"},{"key":"2026091506111303000_ytag658-B11","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.jcin.2024.06.014","article-title":"Transjugular transcatheter tricuspid valve replacement: early compassionate use outcomes","volume":"17","author":"Stolz","year":"2024","journal-title":"JACC Cardiovasc Interv"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytag658\/70922015\/ytag658.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/9\/ytag658\/70922015\/ytag658.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/10\/9\/ytag658\/70922015\/ytag658.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:11:21Z","timestamp":1789467081000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytag658\/8779931"}},"subtitle":[],"editor":[{"given":"Duygu Kocyigit","family":"Burunkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Alessandro","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Deepti","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,8,27]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytag658","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,27]]},"article-number":"ytag658"}}