{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:48:45Z","timestamp":1753876125356,"version":"3.41.2"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is a lack of information about a mixed type of amiodarone-induced thyrotoxicosis (AIT) after heart transplantation (HTx) with no amiodarone treatment in almost 1\u2009year. Frequent ventricular extrasystoles (VES) associated with a mixed type of AIT can often be treated using thiamazole and prednisolone, without the need for specific antiarrhythmic treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We present a clinical case of a 65-year-old heart transplanted male patient with frequent VES associated with mixed type of AIT. Recipient had managed with amiodarone prior to HTx but there were no indications for it after the surgery. One year after antiarrhythmic treatment was discontinued, monomorphic VES (total amount: 27\u00a0472\/day) were diagnosed. In addition, our investigation revealed that thyrotoxicosis developed. Prednisolone and thiamazole were added to the treatment with positive outcomes. The antithyroid treatment had been discontinued after 9\u2009months and results of the 24-h Holter electrocardiogram monitoring showed only two VES\/24\u2009h.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>The case highlights the association of amiodarone, thyroid disorders, and VES. In mixed type AIT or if diagnosis is uncertain, it is reasonable to use mixed therapy. Next is to decide whether you need special treatment for VES. There was no evidence of ventricular tachycardia. Thyroid function tests remained normal off antithyroid medications and the total amount of VES significantly decreased. There were no indications for any antiarrhythmic treatment or ablation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytz030","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T17:06:59Z","timestamp":1553188019000},"source":"Crossref","is-referenced-by-count":1,"title":["Frequent ventricular extrasystoles after heart transplantation: a late presentation of amiodarone-induced thyrotoxicosis: a case report"],"prefix":"10.1093","volume":"3","author":[{"given":"Maria","family":"Simonenko","sequence":"first","affiliation":[{"name":"Physiology Research and Blood Circulation Department, Cardiopulmonary Exercise Test SRL, Federal State Budgetary Institution, \u201cV.A. Almazov National Medical Research Centre\u201d of the Ministry of Health of the Russian Federation, 197341, Akkuratova street, 2, Saint-Petersburg, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Fedotov","sequence":"additional","affiliation":[{"name":"Heart Failure Research Department, Federal State Budgetary Institution \u201cV.A. Almazov National Medical Research Centre\u201d of the Ministry of Health of the Russian Federation, 197341, Akkuratova street, 2, Saint-Petersburg, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Babenko","sequence":"additional","affiliation":[{"name":"Endocrynology Institute, Federal State Budgetary Institution \u201cV.A. Almazov National Medical Research Centre\u201d of the Ministry of Health of the Russian Federation, 197341, Akkuratova street, 2, Saint-Petersburg, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Karpenko","sequence":"additional","affiliation":[{"name":"Scientific Clinical Council, Federal State Budgetary Institution \u201cV.A. Almazov National Medical Research Centre\u201d of the Ministry of Health of the Russian Federation, 197341, Akkuratova street, 2, Saint-Petersburg, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"2019091011593745000_ytz030-B1","first-page":"219","article-title":"Amiodarone-induced thyrotoxicosis","volume":"18","author":"Bogazzi","year":"2017","journal-title":"G Ital Cardiol (Rome)"},{"key":"2019091011593745000_ytz030-B2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1530\/EJE-14-0267","article-title":"The onset time of amiodarone-induced thyrotoxicosis (AIT) depends on AIT type","volume":"171","author":"Tomisti","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"2019091011593745000_ytz030-B3","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1210\/jc.2010-0180","article-title":"Approach to the patient with amiodarone-induced thyrotoxicosis","volume":"95","author":"Bogazzi","year":"2010","journal-title":"J Clin Endocrynol Metabol"},{"key":"2019091011593745000_ytz030-B4","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S1053-2498(02)01149-X","article-title":"Amiodarone therapy before heart transplantation as a predictor of thyroid dysfunction after heart transplantation","volume":"22","author":"Siccama","year":"2003","journal-title":"J Heart Lung Transplant"},{"key":"2019091011593745000_ytz030-B5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cpcardiol.2015.03.002","article-title":"Premature ventricular complexes and premature ventricular complex induced cardiomyopathy","volume":"40","author":"Latchamsetty","year":"2015","journal-title":"Curr Probl Cardiol"},{"key":"2019091011593745000_ytz030-B6","first-page":"26","article-title":"Current concepts of premature ventricular contractions","volume":"3","author":"Ahn","year":"2013","journal-title":"J Lifestyle Med"},{"key":"2019091011593745000_ytz030-B7","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.hrthm.2007.07.020","article-title":"Practical guidelines for clinicians who treat patients with amiodarone: 2007","volume":"4","author":"Goldschlager","year":"2007","journal-title":"Heart Rhythm"},{"key":"2019091011593745000_ytz030-B8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/2042018811398516","article-title":"Management of amiodarone-related thyroid problems","volume":"2","author":"Nayrayana","year":"2011","journal-title":"Ther Adv Endocrinol Metab"},{"key":"2019091011593745000_ytz030-B9","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/thy.2016.0229","article-title":"2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis","volume":"26","author":"Ross","year":"2016","journal-title":"Thyroid"},{"key":"2019091011593745000_ytz030-B10","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.2337\/dc08-2339","article-title":"Graves hyperthyroidism after stopping immunosuppressive therapy in type 1 diabetic islet cell recipients with pretransplant TPO autoantibodies","volume":"32","author":"Gillard","year":"2009","journal-title":"Diabetes Care"},{"key":"2019091011593745000_ytz030-B11","first-page":"868","article-title":"Assessment of early immunosuppressive therapy in the prevention of complications of Graves\u2019 disease","volume":"61","author":"Huszno","year":"2004","journal-title":"Przegl Lek"},{"key":"2019091011593745000_ytz030-B12","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1089\/thy.2015.0647","article-title":"Does immunosuppressive therapy improve outcomes in Graves\u2019 disease? 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Hyperthyroidism under immunosuppression after heart transplantation as a late-onset of amiodarone-treatment","volume":"64","author":"Schmidt","year":"2016","journal-title":"Thorac Cardiovasc Surg"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/3\/2\/ytz030\/28888637\/ytz030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T16:42:52Z","timestamp":1568133772000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytz030\/5416178"}},"subtitle":[],"editor":[{"given":"Tor","family":"Biering-Sorensen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Rami Riziq Yousef","family":"Abumuaileq","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Kyriakos","family":"Dimitriadis","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Christian Fielder","family":"Camm","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Mohammed Majid","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Peregrine","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,20]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,3,20]]},"published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytz030","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2019,6]]},"published":{"date-parts":[[2019,3,20]]},"article-number":"ytz030"}}