{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:46:35Z","timestamp":1757702795991,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brucellosis is a zoonotic infection. Humans contract brucellosis through inhalation of aerosolized infected particles, or when they come in direct contact with infected animal parts, or on consuming unpasteurised dairy products. It can affect multiple organs and systems. Endocarditis is diagnosed late in the course of the disease with mostly aortic valve involvement with serious morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>We report a case series of four patients with Brucella endocarditis. The first patient presented with fever, malaise, and exertional breathlessness. He underwent aortic valve replacement for refractory heart failure and bulky vegetations after failed medical therapy. The second patient presented with fever, breathlessness New York Heart Association (NYHA) III, with arthralgia, myalgia, anorexia, and weight loss. In view of aortic abscess with impending rupture and compression of left main coronary artery, aortic valve replacement was performed on the 4th day of antibiotic treatment. The third patient presented with fever, fatigue, NYHA II, and developed peripheral embolization but responded to medical treatment alone. The fourth patient presented with intermittent fever for 7\u2009months. During hospitalization, he suffered acute limb ischaemia and stroke with absence of left dorsalis pedis and posterior tibial pulsation. Brucella IgG ELISA was positive. Mitral valve replacement was done subsequently with unremarkable hospital course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Brucellosis is a challenging diagnosis to make. The diagnosis and treatment is often delayed as it presents with non-specific symptoms and signs. Cardiac involvement occurs in only 2% of the cases, but accounts for 80% of the mortality due to brucellosis. Brucella endocarditis should be suspected in cases of endocarditis with negative blood cultures and a risk of exposure. The most accepted treatment for Brucella endocarditis is a combination of antimicrobial therapy with surgery.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ehjcr\/ytz035","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T02:24:56Z","timestamp":1555035896000},"source":"Crossref","is-referenced-by-count":3,"title":["A tale of four valves: outcome of Brucella endocarditis: a case series"],"prefix":"10.1093","volume":"3","author":[{"given":"Suraj Kumar","family":"Kulkarni","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bannerghetta Road, Jayanagar 9th block, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivakumar","family":"Bhairappa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bannerghetta Road, Jayanagar 9th block, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kapil","family":"Rangan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bannerghetta Road, Jayanagar 9th block, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beeresh","family":"P","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bannerghetta Road, Jayanagar 9th block, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"2019091011534270600_ytz035-B1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S1473-3099(07)70286-4","article-title":"Human brucellosis","volume":"7","author":"Franco","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"2019091011534270600_ytz035-B2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00005792-199607000-00003","article-title":"Complications associated with Brucella melitensis infection: a study of 530 cases","volume":"75","author":"Colmenero","year":"1996","journal-title":"Medicine"},{"key":"2019091011534270600_ytz035-B3","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10096-003-1026-z","article-title":"Brucella endocarditis: clinical, diagnostic, and therapeutic approach","volume":"22","author":"Reguera","year":"2003","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2019091011534270600_ytz035-B4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1473-3099(06)70382-6","article-title":"The new global map of human brucellosis","volume":"6","author":"Pappas","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"2019091011534270600_ytz035-B5","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1001\/jama.1980.03310200058031","article-title":"Brucellosis in the United States past, present, and future","volume":"244","author":"Wise","year":"1980","journal-title":"JAMA"},{"key":"2019091011534270600_ytz035-B6","first-page":"1309","article-title":"Brucella endocarditis\u2014case report and literature review","volume":"27","author":"Ferreira","year":"2008","journal-title":"Rev Port Cardiol"},{"key":"2019091011534270600_ytz035-B7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0399-077X(02)00403-1","article-title":"Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients","volume":"32","author":"Aygen","year":"2002","journal-title":"Med. 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