{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:08Z","timestamp":1753876208542,"version":"3.41.2"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial septal defect (ASD) and patent ductus arteriosus (PDA) are both common congenital heart diseases, but the combination of these two cardiac defects is extremely rare, and the therapeutic strategy is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>We treated an adult patient with combined ASD and PDA, and safely attained a successful outcome with two-stage transcatheter closure, which is PDA closure preceding ASD closure, to prevent serious complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Transcatheter closure of one of the defects is now widely accepted as an alternative to surgical closure. In addition, adults with both ASD and PDA are better suited for transcatheter closure than surgical closure. One of the reasons is the difficulty to ligate the ductus arteriosus of an adult patient due to its friability and calcification. Meanwhile, simultaneous combined transcatheter closure of ASD and PDA can result in serious complications, such as thrombocytopenia and haemolysis, whose mechanism is considered to be the destruction of platelets and red blood cells by the residual shunt through implanted devices. Additionally, antiplatelet therapy that prevents device-related thrombus formation after ASD closure can possibly exacerbate thrombocytopenia and haemolysis. Therefore, the staged strategy is reasonable from the perspectives of antiplatelet therapy and haemodynamic changes.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ehjcr\/ytz044","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T10:15:15Z","timestamp":1556532915000},"source":"Crossref","is-referenced-by-count":0,"title":["Staged transcatheter closure for atrial septal defect and patent ductus arteriosus: a case report"],"prefix":"10.1093","volume":"3","author":[{"given":"Yusuke","family":"Soma","sequence":"first","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,4,28]]},"reference":[{"key":"2019091012151836300_ytz044-B1","first-page":"281","article-title":"The atrial septal defect-patent ductus arteriosus complex","volume":"131","author":"Cole","year":"1977","journal-title":"Am J Dis Child"},{"key":"2019091012151836300_ytz044-B2","first-page":"1626","article-title":"Patent ductus arteriosus in association with atrial septal defect","volume":"6","author":"Tomino","year":"1974","journal-title":"Shinzo"},{"key":"2019091012151836300_ytz044-B3","first-page":"197","article-title":"Combined transcatheter closure of atrial septal defect and patent ductus arteriosus: report of two cases","volume":"47","author":"Ho","year":"2006","journal-title":"Acta Paediatr Taiwan"},{"key":"2019091012151836300_ytz044-B4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijcard.2016.01.126","article-title":"Simultaneous transcatheter closure of an atrial septal defect and patent ductus arteriosus in an adult case, followed by thrombocytopenia and subclinical hemolysis","volume":"207","author":"Kimura","year":"2016","journal-title":"Int J Cardiol"},{"key":"2019091012151836300_ytz044-B5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1542\/peds.32.1.25","article-title":"Closure of the ductus arteriosus in the newborn infant","volume":"32","author":"Moss","year":"1963","journal-title":"Pediatrics"},{"key":"2019091012151836300_ytz044-B6","doi-asserted-by":"crossref","first-page":"726","DOI":"10.5543\/tkda.2012.47827","article-title":"Percutaneous closure multiple atrial septal defects and patent ductus arteriosus during the same session","volume":"40","author":"Odemi\u015f","year":"2012","journal-title":"Turk Kardiyol Dern Ars"},{"key":"2019091012151836300_ytz044-B7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.5694\/j.1326-5377.1991.tb142228.x","article-title":"Persistent ductus arteriosus in adults. 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