{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:31:08Z","timestamp":1758634268555,"version":"3.37.3"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Fabry disease (FD) is an X-linked lysosomal storage disorder resulting from a deficiency in alpha-galactosidase A. The major causes of death due to cardiac complications include life-threatening arrhythmias. In addition, life-threatening arrhythmias may be related to myocardial fibrosis assessed by late gadolinium enhancement (LGE).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 43-year-old man with sinus bradycardia and left ventricular hypertrophy was referred to our cardiology department. Family history includes unexplained hypertrophy and sick sinus syndrome in mother. Additionally, his plasma alpha-galactosidase A activity was low. He was subsequently diagnosed with FD. Enzyme replacement therapy using 1.0 mg\/kg agalsidase-\u03b2 was initiated. During the fifth administration, he developed ventricular fibrillation (VF). Electrocardiography conducted immediately before VF revealed ST elevation in the inferior leads with reciprocated ST depression. Cardiac magnetic resonance imaging showed no LGE in the myocardium. Coronary angiography showed no organic stenosis; moreover, coronary spasms were induced by an intracoronary acetylcholine injection. Ventricular fibrillation was not observed as the patient received calcium antagonists.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This report suggests that vasospastic angina pectoris is associated with life-threatening arrhythmias in patient with FD without LGE.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytz192","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T11:43:09Z","timestamp":1594986189000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Ventricular fibrillation associated with vasospastic angina pectoris in Fabry disease: a case report"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-5191","authenticated-orcid":false,"given":"Kenji","family":"Kodama","sequence":"first","affiliation":[{"name":"Department of Cardiology, Nagahama Red Cross Hospital, 14-7, Miyamae-cho, Nagahama-shi, Shiga 526-0053, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shiga University of Medical Science Hospital, Tsukinowa, Seta-cho, Otsu-shi, Shiga 520-2134, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5372-1624","authenticated-orcid":false,"given":"Kenichi","family":"Dochi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nagahama Red Cross Hospital, 14-7, Miyamae-cho, Nagahama-shi, Shiga 526-0053, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7686-4364","authenticated-orcid":false,"given":"Yoshiki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nagahama Red Cross Hospital, 14-7, Miyamae-cho, Nagahama-shi, Shiga 526-0053, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"2020071623015309000_ytz192-B1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.2174\/138161282104141204142643","article-title":"The Fabry cardiomyopathy-diagnostic approach and current treatment","volume":"21","author":"Weidemann","year":"2014","journal-title":"Curr Pharm Des"},{"key":"2020071623015309000_ytz192-B2","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s12551-018-0432-5","article-title":"Anderson-Fabry disease in heart failure","volume":"10","author":"Akhtar","year":"2018","journal-title":"Biophys Rev"},{"key":"2020071623015309000_ytz192-B3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1536\/ihj.52.308","article-title":"Clinical and genetic investigation of a Japanese family with cardiac Fabry disease. Identification of a novel \u03b1-galactosidase A missense mutation (G195V)","volume":"52","author":"Nakagawa","year":"2011","journal-title":"Int Heart J"},{"key":"2020071623015309000_ytz192-B4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1253\/jcj.60.315","article-title":"Vasospastic angina in a patient with Fabry\u2019s disease who showed normal coronary angiographic findings","volume":"60","author":"Ogawa","year":"1996","journal-title":"Jpn Circ J"},{"key":"2020071623015309000_ytz192-B5","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.amjcard.2014.06.019","article-title":"Relation of burden of myocardial fibrosis to malignant ventricular arrhythmias and outcomes in Fabry disease","volume":"114","author":"Kr\u00e4mer","year":"2014","journal-title":"Am J Cardiol"},{"key":"2020071623015309000_ytz192-B6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.amjcard.2016.04.033","article-title":"Usefulness of an implantable loop recorder to detect clinically relevant arrhythmia in patients with advances Fabry cardiomyopathy","volume":"118","author":"Weidemann","year":"2016","journal-title":"Am J Cardiol"},{"key":"2020071623015309000_ytz192-B7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jjcc.2007.12.001","article-title":"Terminal stage cardiac findings in patients with cardiac Fabry disease: an electrocardiographic, echocardiographic, and autopsy study","volume":"51","author":"Takenaka","year":"2008","journal-title":"J Cardiol"},{"key":"2020071623015309000_ytz192-B8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/joim.12077","article-title":"Long-term outcome of enzyme-replacement therapy in advanced Fabry disease: evidence for disease progression towards serious complications","volume":"274","author":"Weidemann","year":"2013","journal-title":"J Intern Med"},{"key":"2020071623015309000_ytz192-B9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jcmg.2017.04.006","article-title":"Native T1 mapping and extracellular volume mapping for the assessment of diffuse myocardial fibrosis in dilated cardiomyopathy","volume":"11","author":"Nakamori","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"2020071623015309000_ytz192-B10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/CIRCHEARTFAILURE.108.769729","article-title":"Anigina in Fabry disease reflects coronary small vessel disease","volume":"1","author":"Chimenti","year":"2008","journal-title":"Circ Heart Fail"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/3\/4\/1\/32501036\/ytz192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/3\/4\/1\/32501036\/ytz192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T11:43:14Z","timestamp":1594986194000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/3\/4\/1\/5602181"}},"subtitle":[],"editor":[{"given":"Flavio","family":"D'Ascenzi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Rahul","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Borislav","family":"Dinov","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Mohammed Majiid","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Ross","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,10,21]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,10,21]]},"published-print":{"date-parts":[[2019,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytz192","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2019,12]]},"published":{"date-parts":[[2019,10,21]]}}}