{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:24:14Z","timestamp":1783693454000,"version":"3.55.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF19OC0054908"],"award-info":[{"award-number":["NNF19OC0054908"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To examine whether prescription patterns complied with recommendations not to use non-steroidal anti-inflammatory drugs (NSAIDs) in patients with cardiovascular contraindications. Moreover, we examined predictors for initiation and prescriber responsibility.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We used Danish medical databases to identify all patients with first-time cardiovascular disease during 1996\u20132017 (n\u2009=\u2009628 834). We assessed standardized prevalence proportions, predictors from logistic regression, and prescriber identifiers. One-year prevalence of NSAID initiation increased 3.4% from 1996 (19.4%) to 2001 (22.7%) and declined by 2.7% thereafter until 2017 (13.5%). Trends were independent of age, sex, and disease subtype, although larger annual declines occurred for heart failure (3.9%) and ischaemic heart disease (3.5%) since 2002. One-year prevalence remained highest among patients with venous thromboembolism (16.6%) and angina (13.8%), and lowest for ST-segment elevation myocardial infarction (7.0%) and heart failure (8.8%). Initiators were predominantly prescribed ibuprofen (59%), diclofenac (23%), and etodolac (6%). Diclofenac and coxib use declined, while ibuprofen and naproxen use increased. Median prescribed pill dose of ibuprofen declined after 2008 from moderate\/high (600\u2009mg) to low (400\u2009mg). Treatment duration declined for all NSAIDs, except celecoxib. Rheumatic, obesity, and pain-related conditions predicted NSAID initiation. General practitioners issued 86\u201391% of all NSAID prescriptions, followed by hospital prescribers (7.3\u201312%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Initiation of NSAIDs in patients with cardiovascular disease declined since 2002. Shorter treatment duration, declining COX-2 inhibition, and increasing use of naproxen and low-dose ibuprofen suggest adherence to guidelines when NSAIDs cannot be avoided. Still, NSAID use remained prevalent despite cardiovascular contraindications, warranting awareness of appropriateness of use among general practitioners in particular.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcvp\/pvaa073","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T03:24:34Z","timestamp":1592364274000},"page":"496-506","source":"Crossref","is-referenced-by-count":16,"title":["Prescriber responsibility, predictors for initiation, and 20-year trends in use of non-aspirin non-steroidal anti-inflammatory drugs in patients with cardiovascular contraindications: a nationwide cohort study"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4935-4059","authenticated-orcid":false,"given":"Morten","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes All\u00e9 43-45, 8200 Aarhus N, Denmark"},{"name":"Department of Cardiology, Regional Hospital West Jutland, Gl. Landevej 61, 7400 Herning, Denmark"},{"name":"Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Pharmacy, University of Southern Denmark, JB Winsl\u00f8ws Vej 19, 2nd floor, 5000 Odense C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"2021110402482981200_pvaa073-B1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/eurheartj\/ehv505","article-title":"Cardiovascular safety of non-aspirin non-steroidal anti-inflammatory drugs: review and position paper by the working group for Cardiovascular Pharmacotherapy of the European Society of Cardiology","volume":"37","author":"Schmidt","year":"2016","journal-title":"Eur Heart J"},{"key":"2021110402482981200_pvaa073-B2","author":"U.S. Food & Drug Administration","year":"2005"},{"key":"2021110402482981200_pvaa073-B3","author":"U.S. Food & Drug Administration","year":"2015"},{"key":"2021110402482981200_pvaa073-B4","author":"European Medicines Agency","year":"2006"},{"key":"2021110402482981200_pvaa073-B5","author":"European Medicines Agency","year":"2012"},{"key":"2021110402482981200_pvaa073-B6","author":"European Medicines Agency","year":"2013"},{"key":"2021110402482981200_pvaa073-B7","author":"European Medicines Agency","year":"2015"},{"key":"2021110402482981200_pvaa073-B8","doi-asserted-by":"crossref","first-page":"e1001388","DOI":"10.1002\/phar.2217","article-title":"Nonaspirin nonsteroidal antiinflammatory drug use in the Nordic countries from a cardiovascular risk perspective, 2000-2016: a drug utilization study","volume":"39","author":"Kristensen","year":"2019","journal-title":"Pharmacotherapy"},{"key":"2021110402482981200_pvaa073-B9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/joim.12990","article-title":"Are prescribers not aware of cardiovascular contraindications for diclofenac? A claims data analysis","volume":"287","author":"Scholle","year":"2020","journal-title":"J Intern Med"},{"key":"2021110402482981200_pvaa073-B10","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2147\/CLEP.S179083","article-title":"The Danish health care system and epidemiological research: from health care contacts to database records","volume":"11","author":"Schmidt","year":"2019","journal-title":"Clin Epidemiol"},{"key":"2021110402482981200_pvaa073-B11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10654-014-9930-3","article-title":"The Danish Civil Registration System as a tool in epidemiology","volume":"29","author":"Schmidt","year":"2014","journal-title":"Eur J Epidemiol"},{"key":"2021110402482981200_pvaa073-B12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2147\/CLEP.S59156","article-title":"Potential of prescription registries to capture individual-level use of aspirin and other non-steroidal anti-inflammatory drugs in Denmark: trends in 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