{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:26Z","timestamp":1792785866042,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The Danish Nurses\u2019 Organization"},{"DOI":"10.13039\/100007405","name":"Danish Heart Foundation","doi-asserted-by":"publisher","award":["18-R124-A8454-22099"],"award-info":[{"award-number":["18-R124-A8454-22099"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Patient-reported outcome measures (PROMs) may predict poor clinical outcome in patients with heart failure (HF). It remains unclear whether PROMs are associated with subsequent adherence to HF medication. We aimed to determine whether health-related quality of life, anxiety, and depression were associated with long-term medication adherence in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A national cohort study of Danish patients with HF with 3-year follow-up (n\u2009=\u20091464). PROMs included the EuroQol five-dimensional, five-level questionnaire (EQ-5D-5L), the HeartQoL and the Hospital Anxiety and Depression Scale (HADS). Patient-reported outcomes (PRO) data were linked to demographic and clinical data at baseline, and data on all redeemed prescriptions for angiotensin-converting enzyme inhibitors\/angiotensin II receptor blockers\/angiotensin receptor neprilysin inhibitors (ACEI\/ARB\/ARNI), \u03b2-blockers, and mineralocorticoid receptor antagonists during follow-up. Medication non-adherence was defined as &amp;lt;80% of proportion of days covered. In adjusted regression analyses, lower health-related quality of life (EQ-5D and HeartQoL) and symptoms of depression (HADS-D) at discharge were associated with non-adherence. After 3 years of follow-up, lower health-related quality of life (EQ-5D) was associated with non-adherence for ACEI\/ARB\/ARNI [adjusted OR 2.78, 95% confidence interval (CI): 1.19\u20136.49], \u03b2-blockers (adjusted OR 2.35, 95% CI: 1.04\u20135.29), whereas HADS-D was associated with non-adherence for ACEI\/ARB\/ARNI (adjusted OR 1.07, 95% CI: 1.03\u20131.11) and \u03b2-blockers (adjusted OR 1.06, 95% CI: 1.02\u20131.10).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lower health-related quality of life and symptoms of depression were associated with non-adherence across HF medications at 1 and 3 years of follow-up. Person-centred care using PROMs may carry a potential for identifying patients at increased risk of future medication non-adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcvp\/pvaa097","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T07:28:31Z","timestamp":1596180511000},"page":"287-295","source":"Crossref","is-referenced-by-count":62,"title":["Patient-reported outcomes and medication adherence in patients with heart failure"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9485-7210","authenticated-orcid":false,"given":"Anne Ankerstjerne","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Wiggers","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Center for Clinical Health Services Research, Department of Clinical Medicine, Aalborg University and Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina Kikkenborg","family":"Berg","sequence":"additional","affiliation":[{"name":"Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen \u00d8, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine Bernholdt","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte University Hospital, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Borregaard","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense C, Denmark"},{"name":"Department of Cardiology, Odense University Hospital, Odense C, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Thrysoee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Odense C, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Brun","family":"Thorup","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiothoracic Surgery and Clinical Nursing Research Unit, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke Elmose","family":"Mols","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe Holm","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Paaske","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Danish Center for Clinical Health Services Research, Department of Clinical Medicine, Aalborg University and Aalborg University Hospital, Aalborg, 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