{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:45:40Z","timestamp":1790185540931,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The rising prevalence of obesity and its associated comorbidities represent a growing public health issue; in particular, obesity is known to be a major risk factor for cardiovascular disease. Despite the evidence behind the efficacy of orlistat in achieving weight loss in patients with obesity, no study thus far has quantified its long-term effect on cardiovascular outcomes. The purpose of this study is to explore long-term cardiovascular outcomes after orlistat therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A propensity-score matched cohort study was conducted on the nation-wide electronic primary and integrated secondary healthcare records of the Clinical Practice Research Datalink (CPRD). The 36\u00a0876 patients with obesity in the CPRD database who had completed a course of orlistat during follow-up were matched on a 1:1 basis with equal numbers of controls who had not taken orlistat. Patients were followed up for a median of 6\u2009years for the occurrence of the primary composite endpoint of major adverse cardiovascular events (fatal or non-fatal myocardial infarction or ischaemic stroke), and a number of secondary endpoints including primary endpoint components individually, the occurrence of new-onset heart failure, coronary revascularization, new chronic kidney disease stage III+ (CKD3+), and all-cause mortality. During the median study follow-up of 6\u2009years, the occurrence of major adverse cardiovascular events was lower in the orlistat cohort [hazard ratio (HR) 0.74; 95% confidence interval (CI) 0.66\u20130.83, P\u2009&amp;lt;\u20090.001]. Patients who took orlistat experienced lower rates of myocardial infarction (HR 0.77; 95% CI 0.66\u20130.88, P\u2009&amp;lt;\u20090.001) and ischaemic stroke (HR 0.68; 95% CI 0.56 to \u22120.84, P\u2009&amp;lt;\u20090.001) as well as new-onset heart failure (HR 0.79; 95% CI 0.67\u20130.94, P\u2009=\u20090.007). There was no differences in revascularization rates (HR 1.12; 95% CI 0.91\u20131.38, P\u2009=\u20090.27), but a lower rate of both CKD3+ development (HR 0.78; 95% CI 0.73\u20130.83, P\u2009&amp;lt;\u20090.001) and mortality (HR 0.39, 95% CI 0.36 to \u22120.41, P\u2009&amp;lt;\u20090.001) was observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In this nation-wide, propensity-score matched study, orlistat was associated with lower rates of overall major adverse cardiovascular events, new-onset heart failure, renal failure, and mortality. This study adds to current evidence on the known improvements in cardiovascular risk factor profiles of orlistat treatment by suggesting a potential role in primary prevention.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcvp\/pvaa133","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T20:38:29Z","timestamp":1605904709000},"page":"179-186","source":"Crossref","is-referenced-by-count":38,"title":["Long-term cardiovascular outcomes after orlistat therapy in patients with obesity: a nationwide, propensity-score matched cohort study"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-8117","authenticated-orcid":false,"given":"Maddalena","family":"Ardissino","sequence":"first","affiliation":[{"name":"Department of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, 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UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Eichhorn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK"},{"name":"Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-1979","authenticated-orcid":false,"given":"Alice R","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK"},{"name":"Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, 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