{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:36:51Z","timestamp":1787960211333,"version":"build-2784847793"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We aimed to evaluate the treatment effects of ticagrelor monotherapy in the very high risk cohort of patients with concomitant diabetes mellitus (DM) and chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In the TWILIGHT (Ticagrelor with Aspirin or Alone in High-Risk Patients after Coronary Intervention) trial, after 3-month dual antiplatelet therapy with ticagrelor and aspirin post-PCI, event-free patients were randomized to either aspirin or placebo in addition to ticagrelor for 12 months. Those with available information on DM and CKD status were included in this subanalysis and were stratified by the presence or absence of either condition: 3391 (54.1%) had neither DM nor CKD (DM\u2212\/CKD\u2212), 1822 (29.0%) had DM only (DM+\/CKD\u2212), 561 (8.9%) had CKD only (DM\u2212\/CKD+), and 8.0% had both DM and CKD (DM+\/CKD+). The incidence of the primary endpoint of Bleeding Academic Research Consortium (BARC) type 2, 3, or 5 bleeding did not differ according to DM\/CKD status (P-trend = 0.13), but there was a significant increase in BARC 3 or 5 bleeding (P-trend &amp;lt; 0.001) as well as the key secondary endpoint of death, myocardial infarction, or stroke (P-trend &amp;lt; 0.001). Ticagrelor plus placebo reduced bleeding events compared with ticagrelor plus aspirin across all four groups, including DM+\/CKD+ patients with respect to BARC 2\u20135 [4.5% vs. 8.7%; hazard ratio (HR) 0.49, 95% confidence interval (CI) 0.24\u20131.01] as well as BARC 3\u20135 (0.8% vs. 5.3%; HR 0.15, 95% CI 0.03\u20130.53) bleeding, with no evidence of heterogeneity. The risk of death, myocardial infarction, or stroke was similar between treatment arms across all groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Irrespective of the presence of DM, CKD, and their combination, ticagrelor monotherapy reduced the risk of bleeding without a significant increase in ischaemic events compared with ticagrelor plus aspirin.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcvp\/pvac016","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T20:13:30Z","timestamp":1647893610000},"page":"707-716","source":"Crossref","is-referenced-by-count":13,"title":["Ticagrelor monotherapy after PCI in patients with concomitant diabetes mellitus and chronic kidney disease: TWILIGHT DM-CKD"],"prefix":"10.1093","volume":"8","author":[{"given":"Payam","family":"Dehghani","sequence":"first","affiliation":[{"name":"Department of Cardiology, Prairie Vascular Research , Regina, Saskatchewan, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Cao","sequence":"additional","affiliation":[{"name":"Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029-6574, USA"},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele\u2013Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-5987","authenticated-orcid":false,"given":"Usman","family":"Baber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the University of Oklahoma Health Sciences Center , Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3015-3361","authenticated-orcid":false,"given":"Johny","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029-6574, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-9409","authenticated-orcid":false,"given":"Samantha","family":"Sartori","sequence":"additional","affiliation":[{"name":"Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029-6574, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo A","family":"Pivato","sequence":"additional","affiliation":[{"name":"Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029-6574, USA"},{"name":"Cardio Center, IRCCS Humanitas Research Hospital , Rozzano-Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-0518","authenticated-orcid":false,"given":"Zhongjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029-6574, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Dangas","sequence":"additional","affiliation":[{"name":"Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029-6574, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick J","family":"Angiolillo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Florida College of Medicine , Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2105-8186","authenticated-orcid":false,"given":"Carlo","family":"Briguori","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mediterranea Cardiocentro , Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Cohen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation , New York, NY, USA"},{"name":"Department of Cardiology, St. Francis Hospital , Roslyn, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-277X","authenticated-orcid":false,"given":"Timothy","family":"Collier","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, London School of Hygiene and Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Dudek","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Jagiellonian University Medical College , Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gibson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine , Beth Israel Deaconess Medical Center, , Boston, MA, USA"},{"name":"Harvard Medical School , Beth Israel Deaconess Medical Center, , Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9041-3313","authenticated-orcid":false,"given":"Robert","family":"Gil","sequence":"additional","affiliation":[{"name":"Center of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of Interior and Administration , Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7934-5524","authenticated-orcid":false,"given":"Kurt","family":"Huber","sequence":"additional","affiliation":[{"name":"3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen Hospital, and Medical Faculty, Sigmund Freud University , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upendra","family":"Kaul","sequence":"additional","affiliation":[{"name":"Heart Centre, Batra Hospital and Medical Research Centre , New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Kornowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology , Rabin Medical Center, Petach Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell W","family":"Krucoff","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Duke Clinical Research Institute , Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2975-6971","authenticated-orcid":false,"given":"Vijay","family":"Kunadian","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University and Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust , Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamir","family":"Mehta","sequence":"additional","affiliation":[{"name":"Population Health Research Institute , Hamilton Health Sciences, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Moliterno","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky , Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Magnus","family":"Ohman","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Duke Clinical Research Institute , Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-0112","authenticated-orcid":false,"given":"Javier","family":"Escaned","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico San Carlos IDISCC, Complutense University of Madrid , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Sardella","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Policlinico Umberto I University , Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samin K","family":"Sharma","sequence":"additional","affiliation":[{"name":"Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029-6574, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9422-048X","authenticated-orcid":false,"given":"Richard","family":"Shlofmitz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Francis Hospital , Roslyn, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giora","family":"Weisz","sequence":"additional","affiliation":[{"name":"Division of Cardiology, NewYork Presbyterian Hospital, Columbia University Medical Center , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9322-1926","authenticated-orcid":false,"given":"Bernhard","family":"Witzenbichler","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology , Helios Amper-Klinikum, Dachau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Pocock","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, London School of Hygiene and Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5546-262X","authenticated-orcid":false,"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Center for Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029-6574, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"2022092908584263100_bib1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41581-018-0001-y","article-title":"CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease","volume":"14","author":"Anders","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"2022092908584263100_bib2","doi-asserted-by":"crossref","first-page":"e011139","DOI":"10.1161\/JAHA.118.011139","article-title":"Impact of diabetes mellitus and chronic kidney disease on cardiovascular outcomes and platelet P2Y12 receptor antagonist effects in patients with acute coronary syndromes: insights from the PLATO trial","volume":"8","author":"Franchi","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2022092908584263100_bib3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12933-020-01153-x","article-title":"Ticagrelor monotherapy in patients with concomitant diabetes mellitus and chronic kidney disease: a post hoc analysis of the GLOBAL LEADERS trial","volume":"19","author":"Gao","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"2022092908584263100_bib4","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic kidney disease: challenges, progress, and possibilities","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"2022092908584263100_bib5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2217\/fca-2021-0014","article-title":"Current state-of-the-art antiplatelet and anticoagulation therapy in diabetic patients with coronary artery disease","volume":"17","author":"Nicolas","year":"2021","journal-title":"Future Cardiol"},{"key":"2022092908584263100_bib6","doi-asserted-by":"crossref","first-page":"696","DOI":"10.2337\/dc14-1850","article-title":"Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes and moderate or severe renal impairment: observations from the SAVOR-TIMI 53 trial","volume":"38","author":"Udell","year":"2015","journal-title":"Diabetes Care"},{"key":"2022092908584263100_bib7","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1161\/CIRCULATIONAHA.109.913376","article-title":"Diabetes and antiplatelet therapy in acute coronary syndrome","volume":"123","author":"Ferreiro","year":"2011","journal-title":"Circulation"},{"key":"2022092908584263100_bib8","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1161\/CIRCULATIONAHA.111.084996","article-title":"Antithrombotic therapy in patients with chronic kidney disease","volume":"125","author":"Capodanno","year":"2012","journal-title":"Circulation"},{"key":"2022092908584263100_bib9","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1056\/NEJMoa1908419","article-title":"Ticagrelor with or without aspirin in high-risk patients after PCI","volume":"381","author":"Mehran","year":"2019","journal-title":"N Engl J Med"},{"key":"2022092908584263100_bib10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ahj.2016.09.006","article-title":"Ticagrelor with aspirin or alone in high-risk patients after coronary intervention: rationale and design of the TWILIGHT study","volume":"182","author":"Baber","year":"2016","journal-title":"Am Heart J"},{"key":"2022092908584263100_bib11","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"2022092908584263100_bib12","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.106.685313","article-title":"Clinical end points in coronary stent trials: a case for standardized definitions","volume":"115","author":"Cutlip","year":"2007","journal-title":"Circulation"},{"key":"2022092908584263100_bib13","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1161\/CIR.0b013e31826e1058","article-title":"Third universal definition of myocardial infarction","volume":"126","author":"Thygesen","year":"2012","journal-title":"Circulation"},{"key":"2022092908584263100_bib14","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","author":"National Kidney Foundation","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"2022092908584263100_bib15","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1093\/eurheartj\/ehw378","article-title":"Comparative efficacy of coronary artery bypass surgery vs. percutaneous coronary intervention in patients with diabetes and multivessel coronary artery disease with or without chronic kidney disease","volume":"37","author":"Baber","year":"2016","journal-title":"Eur Heart J"},{"key":"2022092908584263100_bib16","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.3390\/jcm10214931","article-title":"Acute kidney injury following admission with acute coronary syndrome: the role of diabetes mellitus","volume":"10","author":"Shiyovich","year":"2021","journal-title":"J Clin Med"},{"key":"2022092908584263100_bib17","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1001\/jama.2014.11494","article-title":"Prevalence and incidence trends for diagnosed diabetes among adults aged 20 to 79 years, United States, 1980\u20132012","volume":"312","author":"Geiss","year":"2014","journal-title":"JAMA"},{"key":"2022092908584263100_bib18","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1467-985X.2010.00673.x","article-title":"The use of propensity scores to assess the generalizability of results from randomized trials","volume":"174","author":"Stuart","year":"2001","journal-title":"J R Stat Soc Ser A Stat Soc"},{"key":"2022092908584263100_bib19","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jacc.2009.10.043","article-title":"Impact of chronic kidney disease on platelet function profiles in diabetes mellitus patients with coronary artery disease taking dual antiplatelet therapy","volume":"55","author":"Angiolillo","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2022092908584263100_bib20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/ndt\/gft209","article-title":"Haemostasis in chronic kidney disease","volume":"29","author":"Lutz","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"2022092908584263100_bib21","article-title":"Impact of chronic kidney disease on the pharmacodynamic and pharmacokinetic effects Of ticagrelor in patients with diabetes mellitus and coronary artery disease","author":"Franchi","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"2022092908584263100_bib22","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1161\/CIRCULATIONAHA.118.032078","article-title":"P2Y(12)-ADP receptor blockade in chronic kidney disease patients with acute coronary syndromes","volume":"138","author":"Bonello","year":"2018","journal-title":"Circulation"},{"key":"2022092908584263100_bib23","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jacc.2016.11.050","article-title":"Enteric coating and aspirin nonresponsiveness in patients with type 2 diabetes mellitus","volume":"69","author":"Bhatt","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2022092908584263100_bib24","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.2337\/diabetes.54.8.2430","article-title":"Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment","volume":"54","author":"Angiolillo","year":"2005","journal-title":"Diabetes"},{"key":"2022092908584263100_bib25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jacc.2010.09.032","article-title":"Cardiovascular mortality in chronic kidney disease patients undergoing percutaneous coronary intervention is mainly related to impaired P2Y12 inhibition by clopidogrel","volume":"57","author":"Morel","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2022092908584263100_bib26","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.jacc.2014.06.1170","article-title":"Impaired responsiveness to the platelet P2Y12 receptor antagonist clopidogrel in patients with type 2 diabetes and coronary artery disease","volume":"64","author":"Angiolillo","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2022092908584263100_bib27","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jcin.2020.11.046","article-title":"Ticagrelor monotherapy versus dual-antiplatelet therapy after PCI: an individual patient-level meta-analysis","volume":"14","author":"Valgimigli","year":"2021","journal-title":"JACC Cardiovasc Interv"}],"container-title":["European Heart Journal - Cardiovascular Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcvp\/advance-article-pdf\/doi\/10.1093\/ehjcvp\/pvac016\/43773946\/pvac016.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcvp\/article-pdf\/8\/7\/707\/46168253\/pvac016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcvp\/article-pdf\/8\/7\/707\/46168253\/pvac016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T08:59:17Z","timestamp":1664441957000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcvp\/article\/8\/7\/707\/6552954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,23]]},"references-count":27,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,3,23]]},"published-print":{"date-parts":[[2022,9,29]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcvp\/pvac016","relation":{},"ISSN":["2055-6837","2055-6845"],"issn-type":[{"value":"2055-6837","type":"print"},{"value":"2055-6845","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11]]},"published":{"date-parts":[[2022,3,23]]}}}