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Data search included PubMed, Web of Science, and the Cochrane Library. A systematic review of peer-reviewed studies reporting the photosensitizing and\/or skin cancer-inducing properties of common cardiovascular drugs was performed and a guide to clinical management of photoinduced skin eruptions by cardiovascular drugs was provided. Study quality was assessed for major methodological biases. A total of 58 studies were identified (i.e. 23 case reports, 14 observational studies, 10 review articles, 10 experimental studies, and 1 meta-analysis). Most commonly, drug-associated adverse photoinduced cutaneous reactions were caused by phototoxic and photoallergic mechanisms. There is evidence suggesting that amiodarone and dronedarone, thiazide diuretics, thiazide-like diuretics, angiotensin receptor blockers, dihydropyridine-type calcium channel blockers, and certain angiotensin-converting enzyme inhibitors and statins may cause photoinduced adverse cutaneous reactions. Other drugs such as anticoagulants, antiplatelets, aldosterone antagonists, and fibrates have not been linked with photosensitizing reactions or adverse cutaneous reactions. Some drugs, i.e. thiazides and thiazide-like diuretics, were associated with an increased risk of non-melanoma skin cancers (basal cell carcinoma and squamous cell carcinoma). Certain commonly used cardiovascular drugs have been associated with adverse photoinduced cutaneous reactions. If they occur, further diagnosis and treatment might be needed, depending on the severity and progress. Whether photosensitizing drugs increase the risk of skin cancer remains elusive and further randomized controlled trials are required.<\/jats:p>","DOI":"10.1093\/ehjcvp\/pvac017","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T12:21:54Z","timestamp":1646828514000},"page":"420-430","source":"Crossref","is-referenced-by-count":19,"title":["Photoinduced skin reactions of cardiovascular drugs\u2014a systematic review"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-3060","authenticated-orcid":false,"given":"Felix","family":"G\u00f6tzinger","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, University Hospital Saarland, Saarland University , Geb. 41, Kirrbergerstra\u03b2e 100, 66424 Homburg , 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and Intensive Care Medicine, University Hospital Saarland, Saarland University , Geb. 41, Kirrbergerstra\u03b2e 100, 66424 Homburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus R","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Toxicology , , 66421 Homburg , Germany"},{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University , , 66421 Homburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2976-2514","authenticated-orcid":false,"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, University Hospital Saarland, Saarland University , Geb. 41, Kirrbergerstra\u03b2e 100, 66424 Homburg , 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