{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T04:35:12Z","timestamp":1783226112930,"version":"3.54.6"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The objective of the study was to determine the effect of renin\u2013angiotensin system inhibitors (RASI) on the survival of subgroups of patients with aortic stenosis after transcatheter aortic valve implantation (TAVI) and to assess the impact of types and dosages of RASI on outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This single-centre, retrospective analysis included 2862 patients (n\u00a0=\u00a02227 with RASI and n\u00a0=\u00a0635 without RASI) after successful TAVI. Propensity score matching established comparable patient populations (n\u00a0=\u00a0625 per group). Survival was analysed by Kaplan\u2013Meier curves and Cox regression and was corrected for baseline, procedural, and medical parameters. Self-reported adherence to RASI therapy 3 months after hospital discharge was 94%. Three-year all-cause mortality rates were 12.3% and 20.2% for patients with or without RASI, respectively (log-rank\u00a0&amp;lt;0.001).\u00a0In the matched study populations, mortality rates were 14.2%\u00a0vs. 20.0% (log-rank\u00a0&amp;lt;0.03).\u00a0RASI was particularly beneficial in patients with ejection fraction\u00a0&amp;lt;40%\u00a0[adjusted hazard ratio (HR) and 95% confidence interval 0.50 (0.29\u20130.87)], EuroScore II\u00a0\u22654% [HR 0.47 (0.35\u20130.65)], or low-flow, low-gradient aortic stenosis [HR 0.53 (0.31\u20130.93)] who were also on beta-blockers and statins. An association between discharge dosage and survival was observed, with HR 0.75 (0.58\u20130.96) and 0.57 (0.44\u20130.72) for patients on\u00a0&amp;lt;50%\u00a0and\u00a0\u226550% target dose, respectively. Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) reduced mortality rates similarly (13.9%\u00a0vs. 9.8%, log-rank 0.103).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The beneficial association between RASI after TAVI and improved survival during follow-up is particularly evident in high-risk patients and may be dose dependent. No superiority was noted in the effectiveness of ACEI or ARB.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcvp\/pvac027","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T11:10:06Z","timestamp":1650280206000},"page":"815-824","source":"Crossref","is-referenced-by-count":15,"title":["Effects of renin\u2013angiotensin system inhibitor type and dosage on survival after transcatheter aortic valve implantation"],"prefix":"10.1093","volume":"8","author":[{"given":"Ulrich","family":"Fischer-Rasokat","sequence":"first","affiliation":[{"name":"Department of Cardiology, Kerckhoff Heart Center , Benekestr. 2-8, 61231 Bad Nauheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"B\u00e4nsch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kerckhoff Heart Center , Benekestr. 2-8, 61231 Bad Nauheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Renker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kerckhoff Heart Center , Benekestr. 2-8, 61231 Bad Nauheim , Germany"},{"name":"Department of Cardiac Surgery, Kerckhoff Heart Center , Benekestr. 2-8, 61231 Bad Nauheim , Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Rhein-Main , Frankfurt am Main , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8771-297X","authenticated-orcid":false,"given":"Andreas","family":"Rolf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kerckhoff Heart Center , Benekestr. 2-8, 61231 Bad Nauheim , Germany"},{"name":"Medical Clinic I (Cardiology and Angiology), University Hospital of Giessen , Klinikstr. 33, 35392 Giessen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstratios I","family":"Charitos","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Kerckhoff Heart Center , Benekestr. 2-8, 61231 Bad Nauheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Weferling","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kerckhoff Heart Center , Benekestr. 2-8, 61231 Bad Nauheim , Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Rhein-Main , Frankfurt am Main , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Liebetrau","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kerckhoff Heart Center , Benekestr. 2-8, 61231 Bad Nauheim , Germany"},{"name":"Cardioangiological Center Bethanien (CCB) , Im Pr\u00fcfling 23, 60389 Frankfurt , Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Rhein-Main , Frankfurt am Main , 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