{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:08:40Z","timestamp":1787731720590,"version":"build-2784847793"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005760","name":"G\u00f6teborgs Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The association between the use of statins, renin\u2013angiotensin system (RAS) inhibitors, and\/or \u03b2-blockers and long-term mortality in patients with aortic stenosis (AS) who underwent surgical aortic valve replacement (SAVR) is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>All patients with AS who underwent isolated first-time SAVR in Sweden from 2006 to 2017 and survived 6 months after discharge were included. Individual patient data from four mandatory nationwide registries were merged. Cox proportional hazards models, with time-updated data on medication status and adjusted for age, sex, comorbidities, type of prosthesis, and year of surgery, were used to investigate associations between dispensed statins, RAS inhibitors, and \u03b2-blockers and all-cause mortality. In total, 9553 patients were included, and the median follow-up time was 4.9 years (range 0\u201311); 1738 patients (18.2%) died during follow-up. Statins were dispensed to 49.1% and 49.0% of the patients within 6 months of discharge from the hospital and after 10 years, respectively. Corresponding figures were 51.4% and 53.9% for RAS inhibitors and 79.3% and 60.7% for \u03b2-blockers. Ongoing treatment was associated with lower mortality risk for statins {adjusted hazard ratio (aHR) 0.67 [95% confidence interval (95% CI) 0.60\u20130.74]; P\u00a0&amp;lt;\u00a00.001} and RAS inhibitors [aHR 0.84 (0.76\u20130.93); P\u00a0&amp;lt;\u00a00.001] but not for \u03b2-blockers [aHR 1.17 (1.05\u20131.30); P\u00a0=\u00a00.004]. The associations were robust in subgroups based on age, sex, and comorbidities (P for interactions &amp;gt;0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results of this large population-based real-world study support the use of statins and RAS inhibitors for patients who underwent SAVR due to AS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcvp\/pvac034","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T12:06:32Z","timestamp":1652875592000},"page":"837-846","source":"Crossref","is-referenced-by-count":16,"title":["Associations between medical therapy after surgical aortic valve replacement for aortic stenosis and long-term mortality: a report from the SWEDEHEART 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristofer","family":"Skoglund","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sahlgrenska University Hospital , SE 41345 Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-2295","authenticated-orcid":false,"given":"Anders","family":"Jeppsson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine , Sahlgrenska Academy, , Sweden"},{"name":"University of Gothenburg , Sahlgrenska Academy, , Sweden"},{"name":"Department of Cardiothoracic Surgery, Sahlgrenska University Hospital , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1461-0777","authenticated-orcid":false,"given":"Andreas","family":"Martinsson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sahlgrenska 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