{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:34:23Z","timestamp":1791646463740,"version":"4.3.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Center for Integrative Human Physiology"},{"DOI":"10.13039\/100031072","name":"Team Denmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>An increasing number of hypertensive persons travel to high altitude (HA) while using antihypertensive medications such as beta-blockers. Nevertheless, while hypoxic exposure initiates an increase in pulmonary artery pressure (Ppa) and pulmonary vascular resistance (PVR), the contribution of the autonomic nervous system is unclear. In animals, beta-adrenergic blockade has induced pulmonary vasoconstriction in normoxia and exaggerated hypoxic pulmonary vasoconstriction (HPV) and both effects were abolished by muscarinic blockade. We thus hypothesized that in humans, propranolol (PROP) increases Ppa and PVR in normoxia and exaggerates HPV, and that these effects of PROP are abolished by glycopyrrolate (GLYC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In seven healthy male lowlanders, Ppa was invasively measured without medication, with PROP and PROP\u00a0+\u00a0GLYC, both at sea level (SL, 488\u00a0m) and after a 3-week sojourn at 3454\u00a0m altitude (HA). Bilateral thigh-cuff release manoeuvres were performed to derive pulmonary pressure-flow relationships and pulmonary vessel distensibility.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At SL, PROP increased Ppa and PVR from (mean\u00a0\u00b1\u00a0SEM) 14\u00a0\u00b1\u00a01 to 17\u00a0\u00b1\u00a01\u00a0mmHg and from 69\u00a0\u00b1\u00a08 to 108\u00a0\u00b1\u00a011 dyn s cm\u22125 (21% and 57% increase, P\u00a0=\u00a00.01 and P\u00a0&amp;lt;\u00a00.0001). The PVR response to PROP was amplified at HA to 76% (P\u00a0&amp;lt;\u00a00.0001, P[interaction]\u00a0=\u00a00.05). At both altitudes, PROP\u00a0+\u00a0GLYC abolished the effect of PROP on Ppa and PVR. Pulmonary vessel distensibility decreased from 2.9\u00a0\u00b1\u00a00.5 to 1.7\u00a0\u00b1\u00a00.2 at HA (P\u00a0&amp;lt;\u00a00.0001) and to 1.2\u00a0\u00b1\u00a00.2 with PROP, and further decreased to 0.9\u00a0\u00b1\u00a00.2% mmHg\u22121 with PROP\u00a0+\u00a0GLYC (P\u00a0=\u00a00.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our data show that beta-adrenergic blockade increases, and muscarinic blockade decreases PVR, whereas both increase pulmonary artery elastance. Future studies may confirm potential implications from the finding that beta-adrenergic blockade exaggerates HPV for the management of mountaineers using beta-blockers for prevention or treatment of cardiovascular conditions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcvp\/pvae004","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T03:02:36Z","timestamp":1705114956000},"page":"316-328","source":"Crossref","is-referenced-by-count":5,"title":["Beta-adrenergic blockade increases pulmonary vascular resistance and causes exaggerated hypoxic pulmonary vasoconstriction at high altitude: a physiological study"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-881X","authenticated-orcid":false,"given":"Matthias Peter","family":"Hilty","sequence":"first","affiliation":[{"name":"Institute of Intensive Care Medicine, University Hospital of Zurich , ZH 8091 , 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