{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:59:19Z","timestamp":1793048359821,"version":"4.5.0"},"reference-count":112,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Glycoprotein (GP) VI (GPVI) plays a major role in thrombosis but not haemostasis, making it a promising antithrombotic target. The primary role of GPVI on the surface of platelets is a signalling receptor for collagen, which is one of the most potent thrombotic sub-endothelial components that is exposed by atherosclerotic plaque rupture. Inhibition of GPVI has therefore been investigated as a strategy for treatment and prevention of atherothrombosis, such as during stroke and acute coronary syndromes. A range of specific GPVI inhibitors have been characterized, and two of these inhibitors, glenzocimab and revacept, have completed Phase II clinical trials in ischaemic stroke. In this review, we summarize mechanisms of GPVI activation and the latest progress of clinically tested GPVI inhibitors, including their mechanisms of action. By focusing on what is known about GPVI activation, we also discuss whether alternate strategies could be used to target GPVI.<\/jats:p>","DOI":"10.1093\/ehjcvp\/pvae018","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T02:10:47Z","timestamp":1709863847000},"page":"465-473","source":"Crossref","is-referenced-by-count":28,"title":["GPVI inhibition: Advancing antithrombotic therapy in cardiovascular disease"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7166-438X","authenticated-orcid":false,"given":"Alexandre","family":"Slater","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham , B15 2TT, Birmingham , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Khattak","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham , B15 2TT, Birmingham , UK"},{"name":"Cardiology Department, Queen Elizabeth Hospital, University Hospitals Birmingham , B15 2GW, Birmingham , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R","family":"Thomas","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham , B15 2TT, Birmingham , UK"},{"name":"Cardiology Department, Queen Elizabeth Hospital, University Hospitals Birmingham , B15 2GW, Birmingham , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"2024081413471643800_bib1","first-page":"319","article-title":"Mechanism action of platelets and crucial blood coagulation pathways in hemostasis","volume":"11","author":"Periayah","year":"2017","journal-title":"Int J Hematol Oncol Stem Cell Res"},{"key":"2024081413471643800_bib2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.7555\/JBR.29.20150121","article-title":"Platelets in hemostasis and thrombosis: novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis","volume":"29","author":"Hou","year":"2015","journal-title":"J Biomed Res"},{"key":"2024081413471643800_bib3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1055\/s-2007-996108","article-title":"Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis","volume":"23","author":"Schr\u00f6r","year":"1997","journal-title":"Semin Thromb Hemost"},{"key":"2024081413471643800_bib4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11239-011-0667-5","article-title":"P2Y12 platelet inhibition in clinical practice","volume":"33","author":"Damman","year":"2012","journal-title":"J Thromb Thrombolysis"},{"key":"2024081413471643800_bib5","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.2165\/00003495-199856060-00017","article-title":"Tirofiban. 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