{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:18:28Z","timestamp":1793643508585,"version":"4.5.1"},"reference-count":103,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","award":["952166"],"award-info":[{"award-number":["952166"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024065","name":"OM Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Cardiologists have only had rare exposure to haemophilia patients and patients with other congenital bleeding disorders during the last decades, as these patients had a reduced life expectancy and were partly protected against thrombosis due to the bleeding disorder. With the availability of effective and safe replacement therapies of clotting factors, the average life expectancy in these populations of patients has significantly increased, and thrombotic complications may occur.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The European Society of Cardiology Working Group on Thrombosis has taken the initiative to broaden the spectrum of these haematological conditions to include patients with a larger variety of congenital bleeding disorders with concomitant cardiac conditions as compared to a recent position paper by the European Haematology Association in collaboration with other societies (ISTH, European Association for Haemophilia and Allied Disorders, and ESO). Management of antithrombotic therapy or thromboprophylaxis in these individuals is challenging due to the wide phenotypes encompassed by congenital bleeding disorders. These include abnormalities in both primary haemostasis (involving von Willebrand factor and platelet function) and secondary haemostasis (related to coagulation factors and fibrinogen). Bleeding disorders range from mild to very severe. Based on existing literature, we provide clinical consensus statements on optimizing antithrombotic treatment strategies for patients with congenital bleeding disorders and highlight the current gaps in knowledge in these complex clinical settings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Of importance, an individualized approach to antithrombotic therapy is warranted to properly balance the two risks of thrombosis and bleeding. Adoption of the safest interventional techniques, reduction of the intensity and\/or duration of antithrombotic therapies, and attention to the safe levels of clotting factors is generally advised.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcvp\/pvaf006","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T11:13:22Z","timestamp":1743333202000},"page":"275-289","source":"Crossref","is-referenced-by-count":6,"title":["Management of patients with congenital bleeding disorders and cardiac indications for antithrombotic therapy"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-8793","authenticated-orcid":false,"given":"Dan","family":"Atar","sequence":"first","affiliation":[{"name":"Division of Cardiology, Oslo University Hospital Ulleval , Kirkevn. 166, 0450 Oslo ,","place":["Norway"]},{"name":"Institute of Clinical Medicine, University of Oslo , 0316 Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5151-6400","authenticated-orcid":false,"given":"Christophe","family":"Vandenbriele","sequence":"additional","affiliation":[{"name":"Heart Center, OLV Hospital , 9300 Aalst ,","place":["Belgium"]},{"name":"Royal Brompton & Harefield Hospitals, Guy's & St. Thomas\u2019 NHS Foundation Trust , London SW3 6LR ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Agewall","sequence":"additional","affiliation":[{"name":"Division of Clinical Science, Danderyd Hospital, Karolinska Institute Stockholm , 18257 Danderyd\/Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4508-7990","authenticated-orcid":false,"given":"Bruna","family":"Gigante","sequence":"additional","affiliation":[{"name":"Karolinska Institutet Unit of Cardiology, Department of Medicine, , 17177 Stockholm ,","place":["Sweden"]},{"name":"Karolinska University Hospital Department of Cardiology, , 17177 Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8657-6235","authenticated-orcid":false,"given":"Andreas","family":"Goette","sequence":"additional","affiliation":[{"name":"St. Vincenz Hospital Department of Cardiology and Intensive Care Medicine, , 33098 Paderborn ,","place":["Germany"]},{"name":"Otto-von-Guericke University, Medical Faculty , 39106 Magdeburg ,","place":["Germany"]},{"name":"MAESTRIA Consortium, AFNET , 48149 M\u00fcnster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana A","family":"Gorog","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, National Heart and Lung Institute, Imperial College , London SW7 5NH ,","place":["UK"]},{"name":"School of Life and Medical Sciences, Postgraduate Medical School, University of Hertfordshire , Hatfield, Hertfordshire AL10 9AB ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l A","family":"Holme","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo , 0316 Oslo ,","place":["Norway"]},{"name":"Oslo University Hospital Department of Haematology, , 0372 Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin A","family":"Krychtiuk","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Department of Internal Medicine II\u2014Division of Cardiology, , 1090 Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Rocca","sequence":"additional","affiliation":[{"name":"LUM University Department of Medicine and Surgery, , 70010 Casamassima, Bari ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta M","family":"Siller-Matula","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Department of Internal Medicine II\u2014Division of Cardiology, , 1090 Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Valgimigli","sequence":"additional","affiliation":[{"name":"Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale , 6900 Lugano ,","place":["Switzerland"]},{"name":"Bern University Hospital, University of Bern Department of Cardiology, , 3010 Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rubboli","sequence":"additional","affiliation":[{"name":"Internal Medicine and Cardiology, Division of Cardiology, S. 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