{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:16:26Z","timestamp":1779203786284,"version":"3.51.4"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["23212MFDS230"],"award-info":[{"award-number":["23212MFDS230"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["RS-2024-00332632"],"award-info":[{"award-number":["RS-2024-00332632"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To evaluate the risk of incident dementia associated with sacubitril\/valsartan in patients with heart failure (HF) in South Korea.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We conducted a retrospective cohort study using the National Health Insurance Database in South Korea. Patients diagnosed with HF and prescribed either sacubitril\/valsartan or angiotensin-converting enzyme inhibitors (ACEIs)\/angiotensin receptor blockers (ARBs) within 90 days of their first HF diagnosis between October 2017 and December 2020 were included. The primary outcome was incident dementia, categorized into Alzheimer's dementia and vascular dementia. Follow-up began after 1 year from the prescription date, to accommodate dementia onset latency, until the earliest occurrence of dementia, death, or end of study period (March 2023). After 1:4 propensity score matching, the hazard ratio (HR) with 95% confidence interval (CI) for dementia was estimated using a Cox proportional hazards model. Among 7085 sacubitril\/valsartan users and 359\u2009153 ACEI\/ARB users, 6930 sacubitril\/valsartan users [mean (SD) age, 61.7 (14.6) years; 70.9% male] were matched on propensity score to 27\u2009720 ACEI\/ARB users [mean (SD) age, 61.7 (15.8) years; 71.1% male]. During a mean follow-up of 2.2 and 2.3 years, dementia occurred in 200 (2.9%) sacubitril\/valsartan users and 980 (3.5%) ACEI\/ARB users, respectively. Sacubitril\/valsartan showed a 16% lower risk of dementia compared with ACEI\/ARB (HR 0.84; 95% CI 0.72\u20130.98). However, of 1180 cases of incident dementia, 1079 (91.4%) were categorized as Alzheimer's dementia and statistical significance was not reached in this main group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Despite plausible biological mechanisms, no association between sacubitril\/valsartan and an increased risk of dementia was observed in patients with HF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcvp\/pvaf024","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T08:59:14Z","timestamp":1747817954000},"page":"412-421","source":"Crossref","is-referenced-by-count":8,"title":["Association between sacubitril\/valsartan and risk of dementia in patients with heart failure: a nationwide cohort study"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0990-9360","authenticated-orcid":false,"given":"Kyungyeon","family":"Jung","sequence":"first","affiliation":[{"name":"Sungkyunkwan University Department of Biohealth Regulatory Science, , 2066 Seobu-ro, Suwon 16419 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University Department of Biohealth Regulatory Science, , 2066 Seobu-ro, Suwon 16419 ,","place":["South Korea"]},{"name":"School of Pharmacy, Sungkyunkwan University , Suwon 16419 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungho","family":"Bea","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University , Suwon 16419 ,","place":["South Korea"]},{"name":"Brigham and Women's Hospital and Harvard Medical School Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, , Boston, MA 02120 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwa Yeon","family":"Ko","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University , Suwon 16419 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seng Chan","family":"You","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine Department of Biomedical Systems Informatics, , Seoul 03722 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eue-Keun","family":"Choi","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine and Seoul National University Hospital Department of Internal Medicine, , Seoul 03080 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suehyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Gachon University Department of Computer Engineering, , Seongnam 13120 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minsik","family":"Lim","sequence":"additional","affiliation":[{"name":"Gachon University Department of IT Convergence Engineering, , Seongnam 13120 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace Juyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Asan Institute for Life Sciences, Asan Medical Center , Seoul 05505 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Yoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Ulsan University Hospital Department of Preventive Medicine, , Ulsan 44033 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-7525","authenticated-orcid":false,"given":"Ju-Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University Department of Biohealth Regulatory Science, , 2066 Seobu-ro, Suwon 16419 ,","place":["South Korea"]},{"name":"School of Pharmacy, Sungkyunkwan University , Suwon 16419 ,","place":["South Korea"]},{"name":"Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University Department of Clinical Research Design & Evaluation, , Seoul 06355 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"2025081219533146000_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ejhf.2333","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"24","author":"McDonagh","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"2025081219533146000_bib2","first-page":"65","article-title":"In brief: sacubitril\/valsartan (Entresto) expanded indication","volume":"63","year":"2021","journal-title":"Med Lett Drugs Ther"},{"key":"2025081219533146000_bib3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ejhf.687","article-title":"Dementia-related adverse events in PARADIGM-HF and other trials in heart failure with reduced ejection fraction","volume":"19","author":"Cannon","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"2025081219533146000_bib4","article-title":"Neprilysin inhibition does not affect cognitive function in patients with heart failure","author":"Cardiology EESo","year":"2022"},{"key":"2025081219533146000_bib5","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1161\/CIRCULATIONAHA.124.068774","article-title":"Effect of sacubitril\/valsartan on cognitive function in patients with heart failure with preserved ejection fraction: a prespecified analysis of PARAGON-HF","volume":"150","author":"Dewan","year":"2024","journal-title":"Circulation"},{"key":"2025081219533146000_bib6","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA Guideline for the management of Heart Failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"2025081219533146000_bib7","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"2025081219533146000_bib8","doi-asserted-by":"crossref","first-page":"100372","DOI":"10.1016\/j.jacadv.2023.100372","article-title":"Sacubitril\/Valsartan and cognitive outcomes in heart failure with reduced ejection fraction","volume":"2","author":"Grewal","year":"2023","journal-title":"JACC Adv"},{"key":"2025081219533146000_bib9","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00392-023-02322-0","article-title":"Sacubitril\/valsartan and the risk of incident dementia in heart failure: a nationwide propensity-matched cohort study","volume":"113","author":"Lee","year":"2024","journal-title":"Clin Res Cardiol"},{"key":"2025081219533146000_bib10","doi-asserted-by":"crossref","first-page":"754","DOI":"10.4070\/kcj.2020.0171","article-title":"Cardiovascular research using the Korean National Health Information Database","volume":"50","author":"Choi","year":"2020","journal-title":"Korean Circ J"},{"key":"2025081219533146000_bib11","doi-asserted-by":"crossref","first-page":"224","DOI":"10.36628\/ijhf.2021.0023","article-title":"Heart failure statistics in Korea, 2020: a report from the Korean Society of Heart Failure","volume":"3","author":"Park","year":"2021","journal-title":"Int J Heart Fail"},{"key":"2025081219533146000_bib12","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"2025081219533146000_bib13","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.jacc.2016.05.011","article-title":"2016 ACC\/AHA\/HFSA focused update on new pharmacological therapy for Heart Failure: an update of the 2013 ACCF\/AHA Guideline for the management of Heart Failure: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America","volume":"68","author":"Yancy","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2025081219533146000_bib14","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N Engl J Med"},{"key":"2025081219533146000_bib15","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1161\/HYPERTENSIONAHA.119.14388","article-title":"Blood pressure control and dementia risk in midlife patients with atrial fibrillation","volume":"75","author":"Kim","year":"2020","journal-title":"Hypertension"},{"key":"2025081219533146000_bib16","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/s41598-022-05191-1","article-title":"The risk of dementia in adults with abdominal aortic aneurysm","volume":"12","author":"Cho","year":"2022","journal-title":"Sci Rep"},{"key":"2025081219533146000_bib17","doi-asserted-by":"crossref","first-page":"e0169463","DOI":"10.1371\/journal.pone.0169463","article-title":"The Association between polypharmacy and dementia: a nested case-control study based on a 12-year longitudinal cohort database in South Korea","volume":"12","author":"Park","year":"2017","journal-title":"PLoS One"},{"key":"2025081219533146000_bib18","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","article-title":"Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data","volume":"43","author":"Quan","year":"2005","journal-title":"Med Care"},{"key":"2025081219533146000_bib19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.7570\/jomes.2019.28.1.40","article-title":"2018 Korean Society for the Study of Obesity guideline for the management of obesity in Korea","volume":"28","author":"Seo","year":"2019","journal-title":"J Obes Metab Syndr"},{"key":"2025081219533146000_bib20","doi-asserted-by":"crossref","first-page":"100372","DOI":"10.1016\/j.jacadv.2023.100372","article-title":"Sacubitril\/valsartan and cognitive outcomes in heart failure with reduced ejection fraction","volume":"2","author":"Grewal","year":"2023","journal-title":"JACC Adv"},{"key":"2025081219533146000_bib21","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00392-023-02322-0","article-title":"Sacubitril\/valsartan and the risk of incident dementia in heart failure: a nationwide propensity-matched cohort study","volume":"113","author":"Lee","year":"2024","journal-title":"Clin Res Cardiol"},{"key":"2025081219533146000_bib22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/fcp.12837","article-title":"Effect of sacubitril\/valsartan on cognitive impairment in colchicine-induced Alzheimer's model in rats","volume":"37","author":"Hammadi","year":"2023","journal-title":"Fundam Clin Pharmacol"},{"key":"2025081219533146000_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.taap.2017.03.014","article-title":"The effect of angiotensin receptor neprilysin inhibitor, sacubitril\/valsartan, on central nervous system amyloid-\u03b2 concentrations and clearance in the cynomolgus monkey","volume":"323","author":"Schoenfeld","year":"2017","journal-title":"Toxicol Appl Pharmacol"},{"key":"2025081219533146000_bib24","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/bcp.12861","article-title":"The effect of LCZ696 (sacubitril\/valsartan) on amyloid-\u03b2 concentrations in cerebrospinal fluid in healthy subjects","volume":"81","author":"Langenickel","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"2025081219533146000_bib25","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jalz.2014.03.003","article-title":"The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative","volume":"10","author":"Molinuevo","year":"2014","journal-title":"Alzheimers Dement"},{"key":"2025081219533146000_bib26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1001\/jamaneurol.2023.4719","article-title":"Effect of neprilysin inhibition on Alzheimer Disease plasma biomarkers: a secondary analysis of a randomized clinical trial","volume":"81","author":"Brum","year":"2024","journal-title":"JAMA Neurol"},{"key":"2025081219533146000_bib27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1152\/japplphysiol.00454.2020","article-title":"Sacubitril-valsartan improves conduit vessel function and functional capacity and reduces inflammation in heart failure with reduced ejection fraction","volume":"130","author":"Bunsawat","year":"2021","journal-title":"J Appl Physiol"},{"key":"2025081219533146000_bib28","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1177\/1535370219861283","article-title":"LCZ696, an angiotensin receptor-neprilysin inhibitor, ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis","volume":"244","author":"Ge","year":"2019","journal-title":"Exp Biol Med"},{"key":"2025081219533146000_bib29","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3390\/ijms23020616","article-title":"Neuroinflammation: a potential risk for dementia","volume":"23","author":"Ahmad","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025081219533146000_bib30","doi-asserted-by":"crossref","first-page":"e012272","DOI":"10.1161\/JAHA.119.012272","article-title":"Effects of the angiotensin-receptor neprilysin inhibitor on cardiac reverse remodeling: meta-analysis","volume":"8","author":"Wang","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2025081219533146000_bib31","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1161\/CIRCULATIONAHA.117.027448","article-title":"Cerebral perfusion and the risk of dementia: a population-based study","volume":"136","author":"Wolters","year":"2017","journal-title":"Circulation"},{"key":"2025081219533146000_bib32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ahj.2018.07.007","article-title":"Association of left ventricular hypertrophy with cognitive decline and dementia risk over 20 years: the Atherosclerosis Risk In Communities-Neurocognitive Study (ARIC-NCS)","volume":"204","author":"Norby","year":"2018","journal-title":"Am Heart J"},{"key":"2025081219533146000_bib33","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1161\/CIRCULATIONAHA.114.012438","article-title":"Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study","volume":"131","author":"Jefferson","year":"2015","journal-title":"Circulation"},{"key":"2025081219533146000_bib34","doi-asserted-by":"crossref","first-page":"1126587","DOI":"10.3389\/fnagi.2023.1126587","article-title":"Dementia incidence and population-attributable fraction for dementia risk factors in Republic of Korea: a 12-year longitudinal follow-up study of a national cohort","volume":"15","author":"Hwangbo","year":"2023","journal-title":"Front Aging Neurosci"},{"key":"2025081219533146000_bib35","doi-asserted-by":"crossref","first-page":"e0211957","DOI":"10.1371\/journal.pone.0211957","article-title":"Population-based dementia prediction model using Korean public health examination data: a cohort study","volume":"14","author":"Park","year":"2019","journal-title":"PLoS One"},{"key":"2025081219533146000_bib36","doi-asserted-by":"crossref","first-page":"e354","DOI":"10.3346\/jkms.2022.37.e354","article-title":"Effects of socioeconomic status and residence areas on long-term survival in patients with early-onset dementia: the Korean National Health Insurance Service Database Study","volume":"37","author":"Park","year":"2022","journal-title":"J Korean Med Sci"},{"key":"2025081219533146000_bib37","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3233\/JAD-190813","article-title":"Lower left ventricular ejection fraction relates to cerebrospinal fluid biomarker evidence of neurodegeneration in older adults","volume":"74","author":"Kresge","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"2025081219533146000_bib38","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1212\/WNL.0000000000000820","article-title":"NT-proBNP, blood pressure, and cognitive decline in the oldest old: the Leiden 85-plus study","volume":"83","author":"van Vliet","year":"2014","journal-title":"Neurology"},{"key":"2025081219533146000_bib39","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1212\/WNL.0b013e3181b72629","article-title":"Kidney function is associated with the rate of cognitive decline in the elderly","volume":"73","author":"Buchman","year":"2009","journal-title":"Neurology"},{"key":"2025081219533146000_bib40","doi-asserted-by":"crossref","first-page":"101149","DOI":"10.1016\/j.eclinm.2021.101149","article-title":"Clinical outcomes of sacubitril\/valsartan in patients with acute heart failure: a multi-institution study","volume":"41","author":"Chen","year":"2021","journal-title":"EClinicalMedicine"},{"key":"2025081219533146000_bib41","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.2337\/dc12-0788","article-title":"Metformin and the risk of cancer: time-related biases in observational studies","volume":"35","author":"Suissa","year":"2012","journal-title":"Diabetes Care"},{"key":"2025081219533146000_bib42","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s10038-022-01050-z","article-title":"Genetics of Alzheimer's disease: an East Asian perspective","volume":"68","author":"Miyashita","year":"2023","journal-title":"J Hum Genet"},{"key":"2025081219533146000_bib43","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3346\/jkms.2014.29.7.903","article-title":"Prevalence and trends of dementia in Korea: a systematic review and meta-analysis","volume":"29","author":"Kim","year":"2014","journal-title":"J Korean Med Sci"},{"key":"2025081219533146000_bib44","doi-asserted-by":"crossref","first-page":"100257","DOI":"10.1016\/j.lansea.2023.100257","article-title":"Prevalence of dementia among older age people and variation across different sociodemographic characteristics: a cross-sectional study in Bangladesh","volume":"17","author":"Naheed","year":"2023","journal-title":"Lancet Reg Health Southeast Asia"}],"container-title":["European Heart Journal - Cardiovascular Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcvp\/advance-article-pdf\/doi\/10.1093\/ehjcvp\/pvaf024\/63265564\/pvaf024.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcvp\/article-pdf\/11\/5\/412\/63265564\/pvaf024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcvp\/article-pdf\/11\/5\/412\/63265564\/pvaf024.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T23:53:41Z","timestamp":1755042821000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcvp\/article\/11\/5\/412\/8140045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":44,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,21]]},"published-print":{"date-parts":[[2025,8,12]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcvp\/pvaf024","relation":{},"ISSN":["2055-6837","2055-6845"],"issn-type":[{"value":"2055-6837","type":"print"},{"value":"2055-6845","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,5,21]]}}}